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Hirnmorphologische Befunde bei PatientInnen mit Erstmanifestation einer Schizophrenie

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Zusammenfassung

Auf der Grundlage der Forschung der letzten Jahrzehnte, beginnend mit der Darstellung erweiterter Ventrikel mittels Pneumenzephalographie [25], ist es inzwischen unumstritten, dass bei Patientinnen mit Schizophrenie — insbesondere bei chronischem Verlauf — diskret bis mäßig ausgeprägte morphologische Veränderungen von Hirnstrukturen vorliegen. Vor allem bildgebende Verfahren ermöglichen eine In-vivo-Erfassung dieser strukturellen Veränderungen, die konsistent nachweisbar sind, jedoch in weit geringerer Ausprägung als bei neurodegenerativen Erkrankungen wie z.B. der Alzheimer-Demenz. In Vergleichsuntersuchungen schizophrener Patientinnen mit gesunden Kontrollpersonen finden sich daher häufig widersprüchliche Befunde hinsichtlich der Morphologie, insbesondere in Abhängigkeit vom Krankheitsstadium, dessen Einfluss auf die strukturellen Veränderungen letztendlich noch nicht vollständig geklärt ist.

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© Springer-Verlag Berlin Heidelberg 2004

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