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Hirnmorphologische Befunde bei PatientInnen mit Erstmanifestation einer Schizophrenie

  • Conference paper
Universitätskolloquien zur Schizophrenie

  • 139 Accesses

Zusammenfassung

Auf der Grundlage der Forschung der letzten Jahrzehnte, beginnend mit der Darstellung erweiterter Ventrikel mittels Pneumenzephalographie [25], ist es inzwischen unumstritten, dass bei Patientinnen mit Schizophrenie — insbesondere bei chronischem Verlauf — diskret bis mäßig ausgeprägte morphologische Veränderungen von Hirnstrukturen vorliegen. Vor allem bildgebende Verfahren ermöglichen eine In-vivo-Erfassung dieser strukturellen Veränderungen, die konsistent nachweisbar sind, jedoch in weit geringerer Ausprägung als bei neurodegenerativen Erkrankungen wie z.B. der Alzheimer-Demenz. In Vergleichsuntersuchungen schizophrener Patientinnen mit gesunden Kontrollpersonen finden sich daher häufig widersprüchliche Befunde hinsichtlich der Morphologie, insbesondere in Abhängigkeit vom Krankheitsstadium, dessen Einfluss auf die strukturellen Veränderungen letztendlich noch nicht vollständig geklärt ist.

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Literatur

  1. Aboitiz F, Scheibel AB, Fisher RS, Zaidel E (1992) Fiber composition of the human corpus callosum. Brain Res 598:143–153

    Article  PubMed  CAS  Google Scholar 

  2. Andreasen NC, Cohen G, Harris G, Cizadlo T, Parkkinen J, Rezai K, Swayze VW IL (1992) Image processing for the study of brain structure and function: problems and programs. Neuropsychiatry Clin Neurosci 4:125–133

    CAS  Google Scholar 

  3. Andreasen NC, Flashman L, Flaum M, Arndt S, Swayze V 2nd, O’Leary DS, Ehrhardt JC, Yuh WT (1994) Regional brain abnormalities in schizophrenia measured with magnetic resonance imaging. JAMA 272:1763–1769

    Article  PubMed  CAS  Google Scholar 

  4. Andreasen NC, O’Leary DS, Cizadlo T, Arndt S, Rezai K, Boles Ponto LL, Watkins GL, Hichwa RD (1996) Schizophrenia and cognitive dysmetria: a positron-emission tomography study of dysfunctional prefrontal-thalamic-cerebellar circuitry. Proc Nat Acad Sei USA 93:9985–9990

    Article  CAS  Google Scholar 

  5. Andreasen NC, O’Leary DS, Paradiso S, Cizadlo T, Arndt S, Watkins GL, Ponto LL, Hichwa RD (1999) The cerebellum plays a role in conscious episodic memory retrieval. Hum Brain Mapp 8: 226–234

    Article  PubMed  CAS  Google Scholar 

  6. Bachmann S, Pantel J, Flender A, Bottmer C, Essig M, Schröder J (2003) Corpus callosum in first-episode patients with schizophrenia — a magnetic resonance imaging study. Psychol Med 36: 1019–1027

    Article  Google Scholar 

  7. Bertolino A, Esposito G, Callicott JH, Mattay VS, Horn JD van, Frank JA, Berman KF, Weinberger DR (2000) Specific relationship between prefrontal neuronal N-acetylaspartate and activation of working memory cortical network in schizophrenia. Am J Psychiatry 157: 26–33

    PubMed  CAS  Google Scholar 

  8. Bogerts B, Ashtari M, Degreef G, Alvir JM, Bilder RM, Lieberman JA (1990) Reduced temporal limbic structure volumes on magnetic resonance images in first episode schizophrenia. Psychiatry Res 35: 1–13

    Article  PubMed  CAS  Google Scholar 

  9. Bottmer C, Bachmann S, Pantel J, Essig M, Amann M, Schad LR, Magnotta V, Schröder J (2004) Reduced cerebellar volume and neurological soft signs in first-episode schizophrenia. Psychiatry Res (in press)

    Google Scholar 

  10. Buchanan RW, Breier A, Kirkpatrick B, Elkashef A, Munson RC, Gellad F, Carpenter WT Jr. (1993) Structural abnormalities in deficit and nondeficit schizophrenia. Am J Psychiatry 150: 59–65

    PubMed  CAS  Google Scholar 

  11. Cannon TC, Mednick SA, Parnas J (1989) Genetic and perinatal determinants of structural brain deficits in schizophrenia. Arch Gen Psychiatry 46: 883–889

    Article  PubMed  CAS  Google Scholar 

  12. Clarke RM, Zaidel E (1994) Anatomical-behavioral relationships: corpus callosum morphometry and hemispheric specialization. Behav Brain Res 64:185–202

    Article  PubMed  CAS  Google Scholar 

  13. Chua SE, Sharma T, Takei N, Murray RM, Woodruff PW (2000) A magnetic resonance imaging study of corpus callosum size in familial schizophrenic subjects, their relatives, and normal controls. Schizophr Res 41:397–403

    Article  PubMed  CAS  Google Scholar 

  14. Corson PW, Nopoulos P, Miller DD, Arndt S, Andreasen NC (1999) Change in basal ganglia volume over 2 years in patients with schizophrenia: typical versus atypical neuroleptics. Am J Psychiatry 156:1200–1204

    PubMed  CAS  Google Scholar 

  15. Crow TJ (1998) Schizophrenia is a transcallosal misconnection syndrome. Schizophr Res 30: 111–114

    Article  PubMed  CAS  Google Scholar 

  16. De Lacoste MC, Adesanya T, Woodward DJ (1990) Measures of gender differences in the human brain and their relationship to brain weight. Biol Psychiatry 28:931–942

    Article  PubMed  Google Scholar 

  17. DeLisi LE, Stritzke PH, Holan V, Anand A, Boccio A, Kuschner M, Riordan H, McClelland J, VanEyle O (1991) Brain morphological changes in 1st episode cases of schizophrenia: are they progressive? Schizophr Res 5:206–208

    Article  PubMed  CAS  Google Scholar 

  18. DeLisi LE, Tew W, Xie S, Hoff AL, Sakuma M, Kushner M, Lee G, Shedlack K, Smith AM, Grimson R (1995) A prospective follow-up study of brain morphology and cognition in first-episode schizophrenic patients: preliminary findings. Biol Psychiatry 38:349–360

    Article  PubMed  CAS  Google Scholar 

  19. DeLisi LE, Sakuma M, Kushner M, Finer DL, Hoff AL, Crow TJ (1997) Anomalous cerebral asymmetry and language processing in schizophrenia. Schizophr Bull 23:255–271

    Article  PubMed  CAS  Google Scholar 

  20. Downhill JE, Buchsbaum MS, Wie T, Spiegel-Cohen J, Hazlett EA, Haznedar MM, Silverman J, Siever LJ (2000) Shape and size of the corpus callosum in schizophrenia and schizotypal personality disorder. Schizophr Res 42:193–208

    Article  PubMed  Google Scholar 

  21. Flaum M, Swayze VW 2nd, O’Leary DS, Yuh WT, Ehrhardt JC, Arndt SV, Andreasen NC (1995) Effects of diagnosis, laterality, and gender on brain morphology in schizophrenia. Am J Psychiatry 152: 704–714

    PubMed  CAS  Google Scholar 

  22. Flor-Henry P (1978) Gender, hemispheric specialization and psychopathology. Soc Sei Med 12B:155–162

    Google Scholar 

  23. Goldman-Rakic P (1994) Cerebral cortical mechanisms in schizophrenia. Neuropsychopharmacol 10(Suppl 3): 22–27

    Google Scholar 

  24. Gur RE, Maany V, Mozley PD, Swanson C, Bilker W, Gur RC (1998) Subcortical MRI volumes in neuroleptic-naive and treated patients with schizophrenia. Am J Psychiatry 155:1711–1717

    PubMed  CAS  Google Scholar 

  25. Hoff AL, Neal C, Kushner M, DeLisi LE (1994) Gender differences in corpus callosum size in first-episode schizophrenics. Biol Psychiatry 35: 913–919

    Article  PubMed  CAS  Google Scholar 

  26. Holloway RL, Anderson PJ, Defendini R, Harper C (1993) Sexual dimorphism of the human corpus callosum from three independent samples: relative size of the corpus callosum. Am J Phys Anthropol 92: 481–498

    Article  PubMed  CAS  Google Scholar 

  27. Huber G (1957) Pneumencephalographische und psychopathologische Bilder bei endogenen Psychosen. Springer, Berlin, Göttingen, Heidelberg

    Book  Google Scholar 

  28. Kay SR, Fiszbein A, Opler LA (1987) The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull 13: 261–276

    Article  PubMed  CAS  Google Scholar 

  29. Meisenzahl EM, Frodl T, Greiner J, Leinsinger G, Maag KP, Heiss D, Hahn K, Hegerl U, Möller HJ (1999) Corpus callosum size in schizophrenia — a magnetic resonance imaging analysis. Eur Arch Psychiatry Clin Neurosci 249: 305–312

    Article  PubMed  CAS  Google Scholar 

  30. Nasrallah HA, Andreasen NC, Coffman JA, Olson SC, Dunn VD, Ehrhardt JC, Chapman SM (1986) A controlled magnetic resonance imaging study of corpus callosum thickness in schizophrenia. Biol Psychiatry 21: 274–282

    Article  PubMed  CAS  Google Scholar 

  31. Nasrallah HA, Schwarzkopf SB, Olson SC, Coffman JA (1990) Gender differences in schizophrenia on MRI brain scans. Schizophr Bull 16:205–210

    Article  PubMed  CAS  Google Scholar 

  32. Nasrallah HA, Schwarzkopf SB, Olson SC, Coffman JA (1991) Perinatal brain injury and cere-bellar vermal lobules I-X in schizophrenia. Biol Psychiatry 29: 567–574

    Article  PubMed  CAS  Google Scholar 

  33. Oldfield RC (1971) The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia 9: 97–113

    Article  PubMed  CAS  Google Scholar 

  34. Osherson D, Perani D, Cappa S, Schnur T, Grassi F, Fazio F (1998) Distinct brain loci in deductive versus probabilistic reasoning. Neuropsychologia 36: 369–376

    Article  PubMed  CAS  Google Scholar 

  35. Pantel J, Schroeder J, Jauss M, Essig M, Minakaran R, Schoenknecht P, Schneider G, Schad LR, Knopp MV (1999) The topography of callosal atrophy reflects distribution of regional cerebral volume reduction in Alzheimer’s disease. Psychiatry Res Neuroimaging 90:181–192

    Article  CAS  Google Scholar 

  36. Raine A, Harrison GN, Reynolds GP, Sheard C, Cooper JE, Medley I (1990) Structural and functional characteristics of the corpus callosum in schizophrenics, psychiatric controls, and normal controls. Arch Gen Psychiatry 47:1060–1064

    Article  PubMed  CAS  Google Scholar 

  37. Schröder J (1998) Subsyndrome der chronischen Schizophrenic Untersuchungen mit bildgebenden Verfahren zur Heterogenität schizophrener Psychosen. Springer, Berlin Heidelberg

    Book  Google Scholar 

  38. Schröder J, Niethammer R, Geider FJ, Reitz C, Binkert M, Jauß M, Sauer H (1992) Neurological soft signs in schizophrenia. Schizophr Res 6: 25–30

    Article  Google Scholar 

  39. Schröder J, Silvestri S, Bubeck B, Karr M, Demisch S, Scherrer S, Geider FJ, Sauer H (1998) D2 Dopamine receptor up-regulation, treatment response, neurological soft signs, and extrapyramidal side effects in schizophrenia. Biol Psychiatry 43:660–665

    Article  PubMed  Google Scholar 

  40. Schröder J, Essig M, Baudendistel K, Jahn T, Gerdsen I, Stockert A, Schad LR, Knopp M (1999) Motor dysfunction and sensorimotor cortex activation changes in schizophrenia: a study with functional magnetic resonance imaging. Neurolmage 9: 81–87

    Article  Google Scholar 

  41. Schröder J, Bottmer C, Pantel J (2002) Are structural cerebral changes progressive in early schizophrenia? In: Häfner H (ed) Risk and protective factors in schizophrenia. Steinkopff, Darmstadt, pp 83–98

    Chapter  Google Scholar 

  42. Smith RC, Calderon M, Ravichandran GK, Largen J, Vroulis G, Shvartsburd A, Gordon J, Schoolar JC (1984) Nuclear magnetic resonance in schizophrenia: a preliminary study. Psychiatry Res 12:137–147

    Article  PubMed  CAS  Google Scholar 

  43. Steinmetz H, Staiger JF, Schlaug G, Huang Y, Jäncke L (1995) Corpus callosum and brain volume in women and men. Neuroreport 6:1002–1004

    Article  PubMed  CAS  Google Scholar 

  44. Wittchen HU, Wunderlich U, Gruschwitz S, Zaudig M (1997) SKID-I. Strukturiertes klinisches Interview für DSM-IV. Hogrefe, Göttingen, Bern, Toronto, Seattle

    Google Scholar 

  45. Woodruff PWR, Pearlson GD, Geer MJ, Barta PE, Chilcoat HD (1993) A computerized magnetic resonance imaging study of corpus callosum morphology in schizophrenia. Psychol Med 23:45–56

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. S. Bachmann
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  2. C. Bottmer
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  3. J. Pantel
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  4. M. Essig
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  5. J. Schröder
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Editors and Affiliations

  1. Klinik für Psychiatrie und Psychotherapie, Ludwig-Maximilians-Universität München, Nußbaumstr. 7, 80336, München

    Hanns Hippius (em. o. Professor für Psychiatrie) (em. o. Professor für Psychiatrie)

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© 2004 Springer-Verlag Berlin Heidelberg

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Bachmann, S., Bottmer, C., Pantel, J., Essig, M., Schröder, J. (2004). Hirnmorphologische Befunde bei PatientInnen mit Erstmanifestation einer Schizophrenie. In: Hippius, H. (eds) Universitätskolloquien zur Schizophrenie. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-7985-1957-2_3

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  • DOI: https://doi.org/10.1007/978-3-7985-1957-2_3

  • Publisher Name: Steinkopff, Heidelberg

  • Print ISBN: 978-3-642-62369-1

  • Online ISBN: 978-3-7985-1957-2

  • eBook Packages: Springer Book Archive

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