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Tiefe Hirnstimulation des somatosensorischen Thalamus bei therapierefraktären Schmerzen

  • V. M. Tronnier

Zusammenfassung

Neben der damals etablierten Methode, bei Patienten mit chronischen Schmerzen gezielte Läsionen im Bereich der Schmerzleitungsbahnen zu setzen [61], entwickelte sich in den 50er Jahren des letzten Jahrhunderts die Vorstellung einer Neuromodulation zur positiven Verstärkung bestimmter Hirnareale. Heath [24] und Pool [53] beobachteten bei psychiatrischen Patienten eine Schmerzreduktion durch die Stimulation im Bereich der septalen Kerngebiete. Heath und Mickle setzten diese Technik dann wenig später bei sechs Patienten mit Malignomschmerzen und rheumatischer Arthritis [25] ein. Ervin beschrieb eine Schmerzreduktion bei einem Patienten mit malignom-induzierten Schmerzen im Gesichtsbereich durch eine Stimulation im Nucleus caudatus [15]. Gol berichtete jedoch über eine lediglich mäßige Schmerzreduktion durch eine Stimulation im Nucleus caudatus und der septalen Kerne [21].

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Literatur

  1. 1.
    Adams JE, Hosobuchi Y, Fields HL (1974) Stimulation of internal capsule for relief of chronic pain. J Neurosurg 41:740–744PubMedCrossRefGoogle Scholar
  2. 2.
    Adams JE, Hosobuchi Y, Linchitz R (1977) The present status of implantable intracranial stimulators for pain. Clin Neurosurg 24:347–361PubMedGoogle Scholar
  3. 3.
    Apkarian AV, Hodge Jr CJ (1989) Primate spinothalamic pathways. III. thalamic terminations of the dorsolateral and ventral spinothalamic pathways. J Comp Neurol 288:493–511PubMedCrossRefGoogle Scholar
  4. 4.
    Bechtereva NP, Bondcharuk AN, Smirnov VM, Melyucheva LA (1972) Curative electric stimulation of deep-lying brain structures. Vopr Neirokhir 1:7–12Google Scholar
  5. 5.
    Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J (1961) An inventory for measuring depression. Arch Gen Psychiat 4:561–571PubMedCrossRefGoogle Scholar
  6. 6.
    Benabid AL, Henriksen SJ, McGinty JF, Bloom FE (1983) Thalamic nucleus ventroposterolateralis inhibits nucleus parafascicularis response to noxious stimuli through a non opioid pathway. Brain Res 280:217–231PubMedCrossRefGoogle Scholar
  7. 7.
    Blomquist A, Zhang ET, Craig JAD (2000) Cytoarchitectonic and immunohistochemical characterization of a specific pain and temperature relay, the posterior portion of the ventral medial nucleus in the human thalamus. Brain 123:601–19CrossRefGoogle Scholar
  8. 8.
    Broggi G, Franzini A, Giorgi C, Servello D, Spreafico R (1984) Preliminary results of specific thalamic stimulation for deafferentation pain. Acta neurochirur (Suppl 33):497–500Google Scholar
  9. 9.
    Cassinari V, Pagni P (1969) Central pain: a neurosurgical survey. Harvard University Press, Cambridge, MAGoogle Scholar
  10. 10.
    Cesaro P, Amsallem B, Pollin B, Nguyen-Legros J, Moretti JL (1986) Organization of the median and intralaminar nuclei of the thalamus: hypotheses on their role in the onset of certain central pain. Rev Neurol 142:297–302PubMedGoogle Scholar
  11. 11.
    Chung JM, Lee KH, Surmeier DJ, Sorkin LS, Kim J, Willis WD (1986) Response characteristics of neurons in the ventral posterior lateral nucleus of the monkey thalamus. J Neurophysiol 56:370–390PubMedGoogle Scholar
  12. 12.
    Craig AD, Bushnell MC, Zhang ET, Blomqvist A (1994) A thalamic nucleus specific for pain and temperature sensation. Nature 372:770–773PubMedCrossRefGoogle Scholar
  13. 13.
    Dieckmann G, Witzmann A (1982) Initial and longterm results of deep brain stimulation for chronic intractable pain. Appl Neurophysiol 45:167–172PubMedGoogle Scholar
  14. 14.
    Duncan GH, Bushnell MC, Marchand S (1991) Deep brain Stimulation: a review of basic research and clinical studies. Pain 45:49–59PubMedCrossRefGoogle Scholar
  15. 15.
    Ervin FR, CEB, Mark VH (1966) Striatal influence on facial pain. Confinia Neurol 27:75–86CrossRefGoogle Scholar
  16. 16.
    Fields HL, Adams JE (1974) Pain after cortical injury relieved by electrical stimulation of the internal capsule. Brain 97:169–178PubMedCrossRefGoogle Scholar
  17. 17.
    Fishbain DA, Cutler RB, Rosomoff H, Steele-Rosomoff R (1997) Chronic pain-associated depression: antecedent or consequence of chronic pain? Clin J Pain 13:116–137PubMedCrossRefGoogle Scholar
  18. 18.
    Geissner E, Dalbert C, Schulte A (1992) Die Messung der Schmerzempfindung. In: Geissner E, Jungnitsch G (Hrsg) Psychologie des Schmerzes. Psychologie Verlags Union, Weinheim, S 79Google Scholar
  19. 19.
    Gerhart KD, Yezierski RP, Wilcox TK, Grossman AE, Willis WD (1981) Inhibition of primate spinothalamic tract neurons by Stimulation in ipsilateral or contralateral ventral posterior lateral (VPLC) thalamic nucleus. Brain Res 229:514–519PubMedCrossRefGoogle Scholar
  20. 20.
    Gerhart KD, Yezierski RP, Fang ZR, Willis WD (1983) Inhibition of spinothalamic tract neurons by Stimulation in ventral posterior lateral (VPL) thalamic nuclei. J Neurophysiol 49:406–423PubMedGoogle Scholar
  21. 21.
    Gol A (1967) Relief of pain by electrical stimulation of the septal area. J Neurosci 5:115–120Google Scholar
  22. 22.
    Gorecki J, Hirayama T, Dostrovsky JO, Tasker RR, Lenz FA (1989) Thalamic stimulation and recording in patients with deafferentation and central pain. Stereotact Funct Neurosurg 52:219–226PubMedCrossRefGoogle Scholar
  23. 23.
    Gybels J, Kupers R, Nuttin B (1993) What can the neurosurgeon offer in peripheral neuropathic pain? Acta neurochir (Suppl 58):136–140Google Scholar
  24. 24.
    Heath R (1954) Studies in Schizophrenia: a multidisciplinary approach to mind-brain relationships. Harvard University Press, Cambridge, MAGoogle Scholar
  25. 25.
    Heath RG, Mickle WA (1960) Evaluation of 7 years′ experience with depth electrode studies in human patients. In: Ramey ER, O’Doherty DS (eds) Electrical studies on the unanesthetized brain. Hoeber, New York, pp 214–247Google Scholar
  26. 26.
    Hirayama T, Dostrovsky JO, Gorecki J, Tasker RR, Lenz FA (1989) Recordings of abnormal activity in patients with deafferentation and central pain. Stereotact Funct Neurosurg 52:120–126PubMedCrossRefGoogle Scholar
  27. 27.
    Hosobuchi Y, Adams JE, Rutkin B (1973) Chronic thalamic stimulation for the control of facial anesthesia dolorosa. Arch Neurol 29:158–161PubMedCrossRefGoogle Scholar
  28. 28.
    Hosobuchi Y (1983) Combined electrical stimulation of the periaqueductal gray matter and sensory thalamus. Appl Neurophysiol 46:112–115PubMedGoogle Scholar
  29. 29.
    Hosobuchi Y (1986) Subcortical electrical stimulation for control of intractable pain in humans. J Neurosurg 64:543–553PubMedCrossRefGoogle Scholar
  30. 30.
    Jeanmonod D, Magnin M, Morel A (1993) Thalamus and neurogenic pain: physiological, anatomical and clinical data. Neuroreport 4:475–478PubMedCrossRefGoogle Scholar
  31. 31.
    Jones EG, Lensky KM, Chan VH (2001) Delineation of thalamic nuclei immunoreactive for calcium-binding proteins in and around the posterior pole of the ventral posterior complex. Thalamus Related Syst 1:213–224Google Scholar
  32. 32.
    Kenshalo DR, Giesler GJ, Leonard RB, Willis WD (1980) Responses of neurons in primate ventral posterior lateral nucleus to noxious stimuli. J Neurophysiol 43:1594–1614PubMedGoogle Scholar
  33. 33.
    Kumar K, Wyant GM, North R (1990) Deep brain stimulation for control of intractable pain in humans, present and future. 17 year follow-up. Neurosurgery 26:744–782CrossRefGoogle Scholar
  34. 34.
    Lenz FA (1992) The ventral posterior nucleus of thalamus is involved in the generation of central pain syndromes. APS Journal 1:42–51CrossRefGoogle Scholar
  35. 35.
    Lenz FA, Tasker RR, Dostrowsky JO, Kwan HC, Gorecki J, Hirayama T et al. (1987) Abnormal single-unit activity recorded in the somatosensory thalamus of a quadriplegic patient with central pain. Pain 31:225–236PubMedCrossRefGoogle Scholar
  36. 36.
    Lenz FA, Seike M, Lin YC, Baker FH, Rowland LH, Gracely RH et al. (1993) Neurons in the area of human thalamic nucleus ventralis caudalis respond to painful heat stimuli. Brain Res 623:235–240PubMedCrossRefGoogle Scholar
  37. 37.
    Lenz FA, Seike M, Richardson RT, Lin YC, Baker FH, Khoja I et al. (1993) Thermal and pain sensations evoked by microstimulation in the area of human ventrocaudal nucleus. J Neurophysiol 70: 200–212PubMedGoogle Scholar
  38. 38.
    Lenz FA, Gracely RH, Hope EJ (1994) The sensation of angina can be evoked by stimulation of the human thalamus. Pain 59:119–125PubMedCrossRefGoogle Scholar
  39. 39.
    Lenz FA, Gracely RH, Rowland LH, Dougherty PM (1994) A population of cells in the human thalamic principal sensory nucleus respond to painful mechanical stimuli. Neurosci Lett 180:46–50PubMedCrossRefGoogle Scholar
  40. 40.
    Lenz FA, Kwan HC, Martin R, Tasker R, Richardson T, Dostrovsky JO (1994) Characteristics of somatotopic organization and spontaneous neuronal activity in the region of the thalamic principal sensory nucleus in patients with spinal cord transsection. J Neurophysiol 72:1570–1587PubMedGoogle Scholar
  41. 41.
    Lenz FA, Gracely RH, Romanoski AJ, Hope EJ, Rowland LH, Dougherty PM (1995) Stimulation in the human somatosensory thalamus can produce both the affective and sensory dimensions of previously experienced pain. Nature Med 1:910–913PubMedCrossRefGoogle Scholar
  42. 42.
    Lenz FA, Zirh TA, Garonzik IM, Dougherty PM (1998) Neuronal activity in the region of the principle sensory nucleus of the human thalamus (ventralis caudalis) in patients with pain following amputations. Neuroscience 86:1065–1081PubMedCrossRefGoogle Scholar
  43. 43.
    Levy R, Lamb S, Adams JE (1987) Treatment of chronic pain by deep brain stimulation: Long term follow-up and review of the literature. Neurosurgery 6:885–893CrossRefGoogle Scholar
  44. 44.
    Liz-Planells M, Tronnier V, Rinaldi PC (1992) Neural activity of medial and lateral thalamus in a deafferentation model. Soc Neurosci Abstr 18:288Google Scholar
  45. 45.
    Mantyh PW (1983) The spinothalamic tract in primate: a reexamination using wheatgerm agglutinin conjugated with horse radish peroxidase. Neuroscience 9:847–863PubMedCrossRefGoogle Scholar
  46. 46.
    Mazars GJ (1975) Intermittent stimulation of nucleus ventralis posterolateralis for intractable pain. Surg Neurol 4:93–96PubMedGoogle Scholar
  47. 47.
    Mazars GJ (1976) Etat actual de la Chirurgie de la douleur. Neurochirurgie (Suppl 22):95–98Google Scholar
  48. 48.
    Mazars G, Ruge R, Mazars Y (1960) Resultats de la stimulation du faisceau spino-thalamique et leur incidence sur la pathophysiologie de la douleur. Rev Neurol 103:136–138Google Scholar
  49. 49.
    Melzack R, Katz J (1992) The McGill Pain Questionnaire: appraisal and current status. In: Turk DC, Melzack R (eds) Handbook of pain assessment. Guilford, New York, pp 152–168Google Scholar
  50. 50.
    Mundinger F (1977) Die Behandlung chronischer Schmerzen mit Hirnstimulatoren. Dtsch Med Wschr 102:1724–1729PubMedCrossRefGoogle Scholar
  51. 51.
    Nishimoto A, Namba S, Nakao Y, Matsumoto Y, Ohmoto T (1984) Inhibition of nociceptive neurons by internal capsule stimulation. Appl Neurophysiol 47:117–127PubMedGoogle Scholar
  52. 52.
    Plotkin R (1982) Results in 60 cases of deep brain stimulation for chronic intractable pain. Appl Neurophysiol 45:173–178PubMedGoogle Scholar
  53. 53.
    Pool JL, Clark WD, Hudson P, Lombardo M (1956) Hypothalamus-hypophyseal interrelationships. Charles Thomas, SpringfieldGoogle Scholar
  54. 54.
    Portenoy RK, Jarden JO, Sidtis JJ, Lipton RB, Foley KM, Rottenberg DM (1986) Compulsive thalamic self-stimulation: a case with metabolic, electrophysiologic and behavioral correlates. Pain 27:277–290PubMedCrossRefGoogle Scholar
  55. 55.
    Ralston III HJ, Ralston D (1992) The primate dorsal spinothalamic tract: evidence for a specific termination in the posterior nuclei (Po/SG) of the thalamus. Pain 48:107–118PubMedCrossRefGoogle Scholar
  56. 56.
    Rinaldi PC, Young RF, Tronnier VM (1991) Bursting activity of thalamic neurons from chronic pain patients is modified by electrical stimulation in PVG. Soc Neurosci Abstr 17:1560Google Scholar
  57. 57.
    Roldan P, Broseta J, Barcia-Salorio JL (1982) Chronic vpm stimulation for anesthesia dolorosa following trigeminal surgery. Appl Neurophysiol 45:112–113PubMedGoogle Scholar
  58. 58.
    Scott J, Huskisson EC (1976) Graphic representations of pain. Pain 2:175–184PubMedCrossRefGoogle Scholar
  59. 59.
    Siegfried J (1982) Monopolar electrical stimulation of nucleus ventroposteromedialis thalami for postherpetic pain. Appl Neurophysiol 45:179–184PubMedGoogle Scholar
  60. 60.
    Siegfried J (1987) Sensory thalamic neurostimulation for chronic pain. PACE 10:209–212PubMedCrossRefGoogle Scholar
  61. 61.
    Spiegel EA, Wycis HT (1953) Mesencephalotomy in treatment of „intractable“ facial pain. Arch Neurol Psychiat 69:1–13CrossRefGoogle Scholar
  62. 62.
    Tait RC, Chibnall JT, Krause S (1990) The pain disability index: psychometric properties. Pain 40:171–182PubMedCrossRefGoogle Scholar
  63. 63.
    Tronnier VM, Wirtz CR, Knauth M, Bonsanto MM, Hassfeld S, Albert FK et al. (1996) Intraoperative computer-assisted neuronavigation in functional neurosurgery. Stereotact Funct Neurosurg 66:65–68PubMedCrossRefGoogle Scholar
  64. 64.
    Tsubokawa T, Yamamoto T, Katayama Y, Hirayama T, Sibuya H (1984) Thalamic relay nucleus stimulation for relief of intractable pain. Clinical results and β-endorphin immunoreactivity in the cerebrospinal fluid. Pain 18:115–126PubMedCrossRefGoogle Scholar
  65. 65.
    Tsubokawa T, Katayama Y, Yamamoto T, Hirayama T (1985) Deafferentiation pain and stimulation of the thalamic sensory relay nucleus: Clinical and experimental study. Appl Neurophysiol 48:166–171PubMedGoogle Scholar
  66. 66.
    Turnbull IM, Shulman R, Woodhurst B (1980) Thalamic stimulation for neuropathic pain. J Neurosurg 52:486–493PubMedCrossRefGoogle Scholar
  67. 67.
    Ware JE, Sherbourne CD (1992) The MOS 36-item short form of health survey (SF-36). I. Conceptual framework and item selection. Med Care 6:473–483CrossRefGoogle Scholar
  68. 68.
    Yamashiro K, Tomiyama N, Ishida A, Terada Y, Mu-kawa J, Yoshii Yet al. (1997) Characteristics of neurons with high-frequency discharge in the central nervous system and their relationship to chronic pain. Stereotact Funct Neurosurg 68:149–154PubMedCrossRefGoogle Scholar
  69. 69.
    Young RF (1996) Deep brain stimulation for failed back syndrome. In: Gildenberg PL, Tasker RR (eds) Textbook of stereotactic and functional neurosurgery. McGraw-Hill, New York, pp 1621–1625Google Scholar
  70. 70.
    Young RF, Kroening R, Fulton W, Feldman RA, Chambi I (1985) Electrical stimulation of the brain in treatment of chronic pain. J Neurosurg 62:389–396PubMedCrossRefGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 2004

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  • V. M. Tronnier

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