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Tiefe Hirnstimulation des anterioren Thalamus (AN) bei der pharmakoresistenten Epilepsie

  • R. A. Wennberg
  • B. Pohlmann-Eden
  • A. M. Lozano

Zusammenfassung

Die Neurostimulation wurde als eine alternative Form der Epilepsiebehandlung bereits in den 40er Jahren des letzten Jahrhunderts in Erwägung gezogen, nachdem bekannt wurde, dass die Stimulation subkortikaler Strukturen eine signifikante Veränderung des kortikalen Elektronenzephalogramms (EEG) bewirkt: während die Hochfrequenzstimulation (HFS) zu einer Desynchronisierung des EEGs führt, induziert die Niederfrequenzstimulation oder „low frequency Stimulation“ (LFS) eine Synchronisierung [8, 23, 24, 25]. Darüberhinaus konnte gezeigt werden, dass die kortikale Synchronisation bei der LFS epileptische Anfälle begünstigt, wohingegen die Desynchronisierung in Folge der HFS antiepileptisch wirkt [14, 15].

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Copyright information

© Springer-Verlag Berlin Heidelberg 2004

Authors and Affiliations

  • R. A. Wennberg
  • B. Pohlmann-Eden
  • A. M. Lozano

There are no affiliations available

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