Zusammenfassung
Mehrere Beobachtungsstudien weisen auf einen Überlebensvorteil von Frauen bei schwerer Sepsis bzw. eine verminderte Inzidenz septischer Komplikationen nach Trauma hin. Dem könnte der sexuelle Dimorphismus der humoralen und zellulären Immunantwort zugrunde liegen, die bei Frauen und weiblichen Säugetieren verstärkt ist. Interessante neue Studien zeigen darüber hinaus, dass bestimmte Polymorphismen des TNF- und LBP-Genlocus nur bei Männern mit einer schlechteren Prognose der Sepsis assoziiert sind. Derzeit wird diskutiert, ob sich daraus die Notwendigkeit einer geschlechtsspezifischen Behandlung der Sepsis ableiten lässt.
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Müller-Werdan, U. (2004). Die Frau als Intensivpatientin: Sepsis, Beatmung, Sedierung. In: Stangl, V., Baumann, G. (eds) Kardiovaskuläre Notfälle bei Frauen. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-7985-1946-6_6
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DOI: https://doi.org/10.1007/978-3-7985-1946-6_6
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