Skip to main content
SpringerLink
Log in

Extrakorporale Photopherese

  • Chapter
Physikalische Therapiemaßnahmen in der Dermatologie

  • 698 Accesses

Zusammenfassung

Heute hat die ECP einen festen Platz in der Therapie der erythrodermischen Form der Mycosis fungoides und des Sézary-Syndroms. Bei minimaler Toxizität kann bei Ansprechen auf die Behandlung eine deutliche Steigerung der Lebensqualität erzielt werden. Klinische Beobachtungen zeigen, dass weitere potenzielle Anwendungsgebiete im Bereich von Lymphozyten-mediierten Autoimmun- und entzündlichen Erkrankungen und der Behandlung von Transplantat-Abstoßungsreaktionen liegen. Allerdings sollte die Durchführung größerer kontrollierter Studien bei diesen Behandlungsindikationen gefordert werden.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 59.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Barr ML, Meiser BM, Eisen HJ, Roberts RF, Livi U, Dall’Amico R, Dorent R, Rogers JG, Radovancevic B, Taylor DO, Jeevanandam V, Marboe CC (1998) Photopheresis for the prevention of rejec-tion in cardiac transplantation. Photopheresis Transplantation Study Group. N Engl J Med 339:1744–1751

    Article  PubMed  CAS  Google Scholar 

  2. Bisaccia E, Berger C, DiSpaltro FX, Klainer AS (1993) Extracorporeal photopheresis in the treatment of AIDS-related complex: extended trial. J Acquir Immune Defic Syndr 6:386–392

    PubMed  CAS  Google Scholar 

  3. Dall’Amico R, Murer L, Montini G, Andreetta B, Zanon GF, Zacchello G, Zacchello F (1998) Successful treatment of recurrent rejection in renal transplant patients with photopheresis. J Am Soc Nephrol 9:121–127

    Article  PubMed  CAS  Google Scholar 

  4. D’Incan M, Franck F, Kanold J, Bacin F, Achin R, Beyvin AJ, Demeocq F, Souteyrand P (2001) Cutaneo-systemic papulosclerotic mucinosis (scleromyxedema): remission after extracorporeal photochemotherapy and corticoid bolus. Ann Dermatol Venereol 128:38–41

    PubMed  CAS  Google Scholar 

  5. Di Renzo M, Rubegni P, Pasqui AL, Pompella G, De Aloe G, Sbano P, Cuccia A, Castagnini C, Auteri A, Laghi Pasini F, Fimiani M (1997) Extracorporeal photochemotherapy restores Thl/Th2 imbalance in patients with early stage cutaneous T-cell lymphoma. Immunology 92:99–103

    Article  PubMed  Google Scholar 

  6. Dippel E, Schrag H, Goerdt S, Orfanos CE (1997) Extracorporeal photopheresis and interferon-alpha in advanced cutaneous T-cell lymphoma. Lancet 350:32–33

    Article  PubMed  CAS  Google Scholar 

  7. Durani BK, Bock M, Naher H (2001) Extracor-poreal photopheresis-treatment option in scleromyxedema? Hautarzt 52:938–941

    Article  PubMed  CAS  Google Scholar 

  8. Edelson R, Berger C, Gasparro F, Jegasothy B, Heald P, Wintroub B, Vonderheid E, Knobler R, Wolff K, Plewig G, McKiernan G, Christiansen I, Oster M, Hönigsmann H, Wilford H, Kokoschka E, Rehle T, Perez M, Stingl G, Laroche L (1987) Treatment of cutaneous T-cell lymphoma by extracorporeal photochemotherapy. N Engl J Med 316:297–304

    Article  PubMed  CAS  Google Scholar 

  9. Enomoto DN, Schellekens PT, Yong SL, ten Berge IJ, Mekkes JR, Bos JD (1997) Extracorporeal photochemotherapy (photopheresis) induces apoptosis in lymphocytes: a possible mechanism of action of PUVA therapy. Photochem Photobiol 65:177–180

    PubMed  CAS  Google Scholar 

  10. Gilliet M, Cozzio A, Burg G, Nestle FO (2005) Successful treatment of three cases of nephrogenic fibrosing dermopathy with extracorporeal photopheresis. Br J Dermatol 152:531–536

    Article  PubMed  CAS  Google Scholar 

  11. Gorgun G, Miller KB, Foss FM (2002) Immunologic mechanisms of extracorporeal photochemotherapy in chronic graft-versus-host disease. Blood 100:941–947

    Article  PubMed  CAS  Google Scholar 

  12. Greinix HT, Volc-Platzer B, Kalhs P, Fischer G, Rosenmayr A, Keil F, Hönigsmann H, Knobler RM (2000) Extracorporeal photochemotherapy in the treatment of severe steroid-refractory acute graft-versus-host disease: a pilot study. Blood 96:2426–2431

    PubMed  CAS  Google Scholar 

  13. Greinix HT, Volc-Platzer B, Rabitsch W, Gmeinhart B, Guevara-Pineda C, Kalhs P, Krutmann J, Hönigsmann H, Ciovica M, Knobler RM (1998) Successful use of extracorporeal photochemotherapy in the treatment of severe acute and chronic graft-versus-host disease. Blood 92:3098–3104

    PubMed  CAS  Google Scholar 

  14. Heald P, Rook A, Perez M, Wintroub B, Knobler R, Jegasothy B, Gasparro F, Berger C, Edelson R (1992) Treatment of erythrodermic cutaneous T-cell lymphoma with extracorporeal photochemotherapy. J Am Acad Dermatol 27:427–433

    PubMed  CAS  Google Scholar 

  15. Knobler RM, Graninger W, Lindmaier A, Trautinger F, Smolen JS (1992) Extracorporeal photochemotherapy for treatment of sysetmic lupus erythematosus. Arthritis Rheum 35:319–324

    PubMed  CAS  Google Scholar 

  16. Kunte C, Erlenkeuser-Uebelhoer I, Michelsen S, Scheerer-Dhungel K, Plewig G (2005) Treatment of therapy-resistant erosive oral lichen planus with extracorporeal photopheresis (ECP). J Dtsch Dermatol Ges 3:889–894

    Article  PubMed  Google Scholar 

  17. Lauchli S, Zortea-Caflisch C, Nestle FO, Burg G, Kempf W (2004) Nephrogenic fibrosing dermopathy treated with extracorporeal photopheresis. Dermatology 208:278–280

    Article  PubMed  Google Scholar 

  18. Liang G, Nahass G, Kerdel FA (1992) Pemphigus vulgaris treated with photopheresis. J Am Acad Dermatol 26:779–780

    Article  PubMed  CAS  Google Scholar 

  19. Maeda A, Schwarz A, Kernebeck K, Gross N, Aragane Y, Peritt D, Schwarz T (2005) Intravenous infusion of syngeneic apoptotic cells by photopheresis induces antigen-specific regulatory T cells. J Immunol 174:5968–5976

    PubMed  CAS  Google Scholar 

  20. Nestle FO, Haffner AC, Schmid MH, Dummer R, Burg G (1997) Current therapy concepts in cutaneous T-cell lymphomas. Schweiz Med Wochenschr 127:311–320

    PubMed  CAS  Google Scholar 

  21. Radenhausen M, Michelsen S, Plewig G, Bechara FG, Altmeyer P, Hoffmann K (2004) Bicentre experience in the treatment of severe generalized atopic dermatitis with extracorporeal photoche-motherapy. J Dermatol 31:961–970

    PubMed  CAS  Google Scholar 

  22. Richard MA, Saadallah S, Lefevre P, Poullin P, Buscaylet S, Grob JJ (2002) Extracorporeal photo-chemotherapy in therapy-refractory subacute lupus. Ann Dermatol Venereol 129:1023–1026

    PubMed  CAS  Google Scholar 

  23. Richter HI, Krutmann J, Goerz G (1998) Extra-corporeal photopheresis in therapy-refractory disseminated discoid lupus erythematosus. Hautarzt 49:487–491

    Article  PubMed  CAS  Google Scholar 

  24. Romano C, Rubegni P, De Aloe G, Stanghellini E, D’Ascenzo G, Andreassi L, Fimiani M (2003) Ex-tracorporeal photochemotherapy in the treatment of eosinophilic fasciitis. J Eur Acad Dermatol Venereol 17:10–13

    Article  PubMed  CAS  Google Scholar 

  25. Schoch OD, Boehler A, Speich R, Nestle FO (1999) Extracorporeal photochemotherapy for Epstein-Barr virus-associated lymphoma after lung transplantation. Transplantation 68:1056–1058

    Article  PubMed  CAS  Google Scholar 

  26. Slovis BS, Loyd JE, King LE Jr (1995) Photopheresis for chronic rejection of lung allografts. N Engl J Med 332:962

    Article  PubMed  CAS  Google Scholar 

  27. Vowels BR, Cassin M, Boufal MH, Walsh LJ, Rook AH (1992) Extracorporeal photochemotherapy induces the production of tumor necrosis factor-alpha by monocytes: implications for the treat-ment of cutaneous T-cell lymphoma and systemic sclerosis. J Invest Dermatol 98:686–692

    Article  PubMed  CAS  Google Scholar 

  28. Wollina U, Oelzner S, Looks A, Hipler UC, Knoll B, Lange D, Balogh A, Merkel U, Hein G, Oelzner P, Uhlemann C, Vogelsang H (1999) Progressive systemic sclerosis — treatment results of extracorporeal photopheresis. Hautarzt 50:637–642

    Article  PubMed  CAS  Google Scholar 

  29. Zachariae H, Bjerring P, Brodthagen U, Sogaard H (1995) Photopheresis in the red man or preSezary syndrome. Dermatology 190:132–135

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Dermatologische Klinik, Universitätsspital Zürich, Gloriastrasse 31, 8091, Zürich, Schweiz

    Dr. med. J. A. Kamarachev

Authors
  1. Dr. med. J. A. Kamarachev
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Dermatologische Klinik, Universitätsspital Zürich, Gloriastraße 31, 8091, Zürich, Schweiz

    Reinhard Dummer

Rights and permissions

Reprints and permissions

Copyright information

© 2006 Steinkopff Verlag Darmstadt

About this chapter

Cite this chapter

Kamarachev, J.A. (2006). Extrakorporale Photopherese. In: Dummer, R. (eds) Physikalische Therapiemaßnahmen in der Dermatologie. Steinkopff. https://doi.org/10.1007/978-3-7985-1626-7_5

Download citation

  • DOI: https://doi.org/10.1007/978-3-7985-1626-7_5

  • Publisher Name: Steinkopff

  • Print ISBN: 978-3-7985-1625-0

  • Online ISBN: 978-3-7985-1626-7

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics

Search

Navigation