Summary
We generalize the T-optimality criterion for discrimination between two rival multiresponse models with observations corrupted by normally distributed noise with zero mean and a covariance matrix which depends on unknown parameters. Calculation of optimum designs amounts to solving an optimal control problem whose discretization leads to a semi-infinite programming problem. It is then solved numerically using an exchange method. As an example we calculate T-optimum design for discrimination between two complex chemical kinetic reactions. The design variables are the temperature profile during the process run and the initial concentration of reactants.
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References
A.C. Atkinson. Horwitz’s rule, transforming both sides and the design of experiments for mechanistic models. Journal of the Royal Statistical Society, Series C, Applied Statistics52:261–2782003.
A.C. Atkinson and B. Bogacka. Compound and other optimum designs for systems of nonlinear differential equations arising in chemical kinetics. Chemometrics and Intelligent Laboratory Systems61:17–332002.
A.C. Atkinson and R.D. Cook. D-optimum designs for heteroscedastic linear models. Journal of the American Statistical Association90(429):204–2121995.
A.C. Atkinson and A.N. Donev. Optimum Experimental Designs. Clarendon Press, Oxford1992.
A.C. Atkinson and V.V. Fedorov. The design of experiments for discriminating between two rival models. Biometrika62(1):57–701975.
A.C. Atkinson and V.V. Fedorov. Optimal design: Experiments for discriminating between two several models. Biometrika62(2):289–3031975.
A.L. Burke, T.A. Duever, and A. Pendilis. Model discrimination via designed experiments: Discriminating between the terminal and penultimate models on the basis of composition data. Macromolecules27:386–3991994.
D. Downing, V.V. Fedorov, and S. Leonov. Extracting information from the variance function: Optimal design. In A. C. Atkinson, P. Hackl, and W. G. Müller, editorsmODa 6 — Advances in Model-Oriented Design and Analysis (Puchberg/Schneeberg, June 25-29, 2001), pages 45–52. Physica-Verlag, Heidelberg2001.
V. V. Fedorov and P. Hackl. Model-Oriented Design of Experiments. Lecture Notes in Statistics. Springer-Verlag, New York1997.
V.V. Fedorov and V. Khabarov. Duality of optimal design for model discrimination and parameter estimation. Biometrika73(1):183–1901986.
K. Felsenstein. Optimal Bayesian design for discriminating among rival models. Computational Statistics & Data Analysis14:427–4361992.
R. Hettich and K.O. Kortanek. Semi-infinite programming: Theory, methods and applications. SIAM Review35(5):380–4291993.
W.G. Müller and A.C. Ponce de Leon. Discriminating between two binary data models: Sequentially designed experiments. Journal of Statistical Computation and Simulation55:87–1001996.
M.J. Pilling and P.W. Seakins. Reaction Kinetics. Oxford University Press, Oxford1995.
E. Polak. On the mathematical foundations of nondifferentiable optimization in engineering design. SIAM Review29(1):21–891987.
A.C. Ponce de Leon and A.C. Atkinson. Optimum experimental design for discriminating between two rival models in the presence of prior information. Biometrika78(3):601–6081991.
F. Pukelsheim. Optimal Design of Experiments. Probability and Mathematical Statistics. John Wiley & Sons, New York1993.
R. Reemtsen and S. Görner. Numerical methods for semi-infinite programming: A survey. In R. Reemtsen and J.-J. Rückmann, editorsSemi-Infinite Programming, pages 195–275. Kluwer Academic Publishers, Boston1998.
E.W. Sacks. Semi-infinite programming in control. In R. Reemtsen and J.-J. Rückmann, editorsSemi-Infinite Programming, pages 389–411. Kluwer Academic Publishers, Boston1998.
W.E. Stewart, Y. Shon, and G.E.P. Box. Discrimination and goodness of fit of multiresponse mechanistic models. AIChE Journal44(6):1404–14121998.
D. Uciński and B. Bogacka. Construction of T-optimum designs for multiresponse dynamic systems. In W. Härdie and B. Rönz, editorsCompstat 2002, Proceedings in Computational Statistics 2002, pages 267–272Berlin2002. Springer.
D. Uciński and B. Bogacka. T-optimum design for discrimination between two multiresponse dynamic models. Submitted for publication, available at http://www.maths.qmw.ac.uk/~bb/UcinskiBogackal.pdf, 2003.
É. Walter and L. Pronzato. Identification of Parametric Models from Experimental Data. Communications and Control Engineering. Springer-Verlag, Berlin1997.
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Ucinski, D., Bogacka, B. (2004). T-Optimum Designs for Multiresponse Dynamic Heteroscedastic Models. In: Di Bucchianico, A., Läuter, H., Wynn, H.P. (eds) mODa 7 — Advances in Model-Oriented Design and Analysis. Contributions to Statistics. Physica, Heidelberg. https://doi.org/10.1007/978-3-7908-2693-7_21
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DOI: https://doi.org/10.1007/978-3-7908-2693-7_21
Publisher Name: Physica, Heidelberg
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