Common Cold pp 309-347

Part of the Birkhäuser Advances in Infectious Diseases book series (BAID)

Herbal, traditional and alternative remedies

  • Florin Mihail

Abstract

This chapter is composed of sections dealing with some of the well known but, with respect to clinical studies, not always well investigated traditional and alternative treatments against common cold. It includes data on phytotherapy, apitherapy, ayurvedic remedies, homeopathic remedies, Schuessler’s biochemistry, acupuncture and acupressure, nasal irrigation and inhalation.

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References

  1. 1.
    Poolsup N, Suthhisisang C, Prathanturarug S, Asawamekin A, Chanchareon U (2004) Andrographis paniculata in the symptomatic treatment of uncomplicated upper respiratory tract infection: systematic review of randomized controlled trials. J Clin Pharm Ther 29 (1): 37–45PubMedGoogle Scholar
  2. 2.
    Coon JT and Ernst E (2004) Andrographis paniculata in the treatment of upper respiratory tract infections: a systematic review of safety and efficacy. Planta Med 70 (4): 293–298PubMedGoogle Scholar
  3. 3.
    Kigler B, Ulbricht C, Basch E, DeFranco Kirkwood C, Abrams TR, Miranda M, Kahlsa KPS, Giles M, Boon H, Woods J (2006) Andrographis paniculata for the treatment of upper respiratory infection: a systematic review by the Natural Standard Research Collaboration. Explore 2 (1): 25–29Google Scholar
  4. 4.
    Gabrielian ES, Shukarian AK, Goukasova, GI, Chandanian GL, Panosian AG, Wikman G, Wagner H (2002) A double-blind, placebo-controlled study of Andrographis paniculata fixed combination Kan Jang in the treatment of acute upper respiratory tract infections including sinusitis. Phytomedicine 9 (7): 589–597PubMedGoogle Scholar
  5. 5.
    Melchior J, Spasov AA, Ostrovskij OV, Bulanov AE, Wikman G (2000) Double-blind, placebo-controlled pilot and phase III study of activity of standardized Andrographis paniculata Herba Nees extract fixed combination (Kan Jang) in the treatment of uncomplicated upper-respiratory tract infection. Phytomedicine 7 (5): 341–350PubMedGoogle Scholar
  6. 6.
    Spasov AA, Ostrovskij OV, Chernikov MV, Wikman G (2004) Comparative controlled study of Andrographis paniculata fixed combination, Kan Jang and an Echinacea preparation as adjuvant, in the treatment of uncomplicated respiratory disease in children. Phytother Res 18 (1): 47–53PubMedGoogle Scholar
  7. 7.
    Caceres DD, Hancke, JL, Burgos RA (1997) Prevention of common colds with Andrographis paniculata dried extract; a pilot double blind study. Phytomedicine 4: 101–104Google Scholar
  8. 8.
    Caceres DD, Hancke JL, Burgos RA, Sandberg F, Wikman GK (1999) Use of visual analogue scale measurements (VAS) to assess the effectiveness of standardized Andrographis paniculata extract SHA-10 in reducing the symptoms of common cold. A randomized double blind-placebo study. Phytomedicine 6: 217–223PubMedGoogle Scholar
  9. 9.
    Mkrtchyan A., Panosyan V, Panossian A, Wigman G, Wagner H (2005) A phase I clinical study of Andrographis paniculata fixed combination Kan Jang versus ginseng and valerian on the semen quality of healthy male subjects. Phytomedicine 12 (6–7): 403–409PubMedGoogle Scholar
  10. 10.
    KLIGLER B (2003) Echinacea. Am Fam Physician 67: 77–80Google Scholar
  11. 11.
    Dorn M, Knick E, Lewith G (1997) Placebo-controlled, double-blind study of Echinaceae pallidae radix in upper respiratory tract infections. Complement Ther Med 5: 40–42Google Scholar
  12. 12.
    Basch E, Ulbricht C, Basch S, Dalton S, Ernst E, Foppa I, Szapary P, Tiffany N, Orlando CW, Vora M (2005) An evidence-based systematic review of Echinacea (E. angustifolia DC, E. pallida, E. purpurea) by the Natural Standard Research Collaboration. J Herbal Pharmacotherapy 5(2): 57–88Google Scholar
  13. 13.
    Schapowal A (2007) Phytopharmaka bei Atemweigsinfekten in der Pädiatrie (Herbals for respiratory tract infection in paediatrics). Z Phytother 28 (4): 174–180Google Scholar
  14. 14.
    Barrett B, Kiefer D and Rabago D (1999) Assessing the risks and benefits of herbal medicine: an overview of scientific evidence. Alt Therapies 5(4): 40–49Google Scholar
  15. 15.
    Snodgrass WR (2001) Herbal products: risks and benefits of use in children. Current Therapeutic Research 62(10): 724–737Google Scholar
  16. 16.
    Sun LZ, Currier NL, Miller SC (1999) The American coneflower: a prophylactic role involving nonspecific immunity. J Altern Complement Medment Med 5(5):437–46Google Scholar
  17. 17.
    Jurkstiene V, Kondrotas AJ, Kevelaitis E (2004) Compensatory reactions of immune system and action of Purple Coneflower (Echinacea purpurea (L.) Moench) preparations. Medicina (Kaunas) 40(7):657–62Google Scholar
  18. 18.
    Burger RA, Torres AR, Warren RP, Caldwell VD, Hughes BG (1997) Echinacea-induced cytokine production by human macrophages. Int J Immunopharmacol 19(7):371–9PubMedGoogle Scholar
  19. 19.
    Luettig B, Steinmüller C, Gifford GE, Wagner H, Lohmann-Matthes ML (1989) Macrophage activation by the polysaccharide arabinogalactan isolated from plant cell cultures of Echinacea purpurea. J Natl Cancer Inst 81(9):669–75PubMedGoogle Scholar
  20. 20.
    See DM, Broumand N, Sahl L, Tilles JG (1997) In vitro effects of Echinacea and ginseng on natural killer and antibody-dependent cell cytotoxicity in healthy subjects and chronic fatigue syndrome or acquired immunodeficiency syndrome patients. Immunopharmacology 35(3):229–35PubMedGoogle Scholar
  21. 21.
    Mishima S, Saito K, Maruyama H, Inoue M, Yamashita T, Gu Y (2004) Antioxidant and immuno-enhancing effects of Echinacea purpurea. Biol Pharm Bull 27(7):1004–9PubMedGoogle Scholar
  22. 22.
    Sullivan AM, Laba JG, Moore JA, Lee TD (2008) Echinacea-induced macrophage activation. Immunopharmacol Immunotoxicol 30(3):553–74PubMedGoogle Scholar
  23. 23.
    Schwarz E, Metzler J, Diedrich JP, Freudenstein J, Bode C, Bode JC (2002) Oral administration of freshly expressed juice of Echinacea purpurea herbs fail to stimulate the nonspecific immune response in healthy young men: results of a double-blind, placebo-controlled crossover study. J Immunother 25(5):413–20PubMedGoogle Scholar
  24. 24.
    Schwarz E, Parlesak A, Henneicke-von Zepelin HH, Bode JC, Bode C (2005) Effect of oral administration of freshly pressed juice of Echinacea purpurea on the number of various subpopulations of B-and T-lymphocytes in healthy volunteers: results of a double-blind, placebo-controlled cross-over study. Phytomedicine 12(9):625–31PubMedGoogle Scholar
  25. 25.
    Goel V, Lovlin R, Chang C, Slama JV Barton R, Gahler R, Bauer R, Goonewardene L, Basu TK (2005) A proprietary extract from the Echinacea plant (Echinacea purpurea) enhances systemic immune response during a common cold. Phytother Res 19(8):689–94PubMedGoogle Scholar
  26. 26.
    Melchart D, Linde K, Workau F, Bauer R, Wagner H (1994) Immunomodulation with Echinacea — a systematic review of controlled clinical trials. Phytomedicine 1:245–254Google Scholar
  27. 27.
    Bräunig B, Dorn M, Knick E (1992) Zur Stärkung der körpereigenen Abwehr bei grippalen Infekten durch Echinaceae purpureae radix (Echinacea purpurea radix fort the enhancement of the body’s own immune defence mechanisms in influenza-like infections). Z Phytother 13:7–13Google Scholar
  28. 28.
    Barrett B, Vohmann M, Calabrese C (1999) Echinacea for upper respiratory infections. J Fam Pract 48(8):628–635PubMedGoogle Scholar
  29. 29.
    Giles JT, Palat CT 3rd, Chien SH, Chang ZG, Kennedy DT (2000). Evaluation of Echinacea for treatment of the common cold. Pharmacotherapy 20(6):690–7PubMedGoogle Scholar
  30. 30.
    Melchart D, Linde K, Fischer P, Kaesmayr J (1999) Echinacea for preventing and treating the common cold. Cochrane Database Syst Rev (1):CD000530. pub2Google Scholar
  31. 31.
    Cohen HA, Varsano I, Kahan E, Sarrell EM, Uziel Y (2004) Effectiveness of an herbal preparation containing Echinacea, propolis, and vitamin C in preventing respiratory tract infections in children: a randomized, double-blind, placebo-controlled, multicenter study. Arch Pediatr Adolesc Med 158(3):217–21PubMedGoogle Scholar
  32. 32.
    Caruso TJ, Gwaltney JM Jr (2005) Treatment of the common cold with Echinacea: a structured review Clin Infect Dis 40(6): 807–10 Epub 2005 Feb 18.PubMedGoogle Scholar
  33. 33.
    Taylor J, Weber W, Standish L, Quinn H, Goesling J, McGann M, Calabrese C (2003) The efficacy of Echinacea in treating upper respiratory tract infections in children. JAMA 290:2824–30PubMedGoogle Scholar
  34. 34.
    Barrett B, Locken K, Maberry R, Brown R, Bobula J, Alessio D (2002) Treatment of common cold with unrefined Echinacea. Ann Intern Med 137: 1–8Google Scholar
  35. 35.
    Schoop R, Klein P, Suter A, Johnston SL (2006) Echinacea in the prevention of induced rhinvirus colds: a meta-analysis. Clin Ther 28(2):174–83PubMedGoogle Scholar
  36. 36.
    Shah SA, Sander S, White CM, Rinaldi M, Coleman CI (2007) Evaluation of Echinacea for the prevention and treatment of the common cold: a metaanalysis. Lancet Infect Dis 7(7):473–80PubMedGoogle Scholar
  37. 37.
    Linde K, Barrett B, Bauer R, Melchart D, Wölkart K (2008) Echinacea for preventing and treating the common cold (review). Cochrane Database Syst Rev. prepared by the Cochrane Collaboration, The Cochrane Library 4:1–91Google Scholar
  38. 38.
    Woelkart K, Linde K, Bauer R (2008) Echinacea for preventing and treating the common cold. Planta Med 74:633–637PubMedGoogle Scholar
  39. 39.
    Huntley AL, Thompson Coon J, Ernst E (2005) The safety of herbal medicinal products derived from Echinacea species: a systematic review. Drug Safety 28(5):387–400PubMedGoogle Scholar
  40. 40.
    The Natural Standard Research Collaboration Echinacea (Echinacea angustifolia DC, Echinacea pallida, Echinacea purpurea) MayoClinic.com; Drugs & Supplements; Patient Monograph, Copyright © 2008Google Scholar
  41. 41.
    Ang-Lee MK, Moss J, Yuan C-S. (2001) Herbal medicines and perioperative care. JAMA 286(2):208–216PubMedGoogle Scholar
  42. 42.
    Blumenthal M, Busse WR, Goldberg A, Gruenwald J, Hall T, Riggins CW, Rister RS (eds) (1998) The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Austin (TX): American Botanical Council; Boston: Integrative Medicine CommunicationGoogle Scholar
  43. 43.
    Miller LG (1998) Herbal Medicinals — Selected clinical considerations focusing on known or potential drug-herb interactions. Arch Intern Med 158:2200–2211PubMedGoogle Scholar
  44. 44.
    The University of Texas — MD Anderson Cancer Center (2008) Echinacea (Echinacea angustifolia DC, Echinacea pallida, Echinacea purpurea). Natural Standard Monograph, Copyright © 2008, accessed Dec. 8, 2008Google Scholar
  45. 45.
    Budzinski JW, Foster BC, Vandenhoek S, Arnason JT (2000) An In vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine 7(4):273–82PubMedGoogle Scholar
  46. 46.
    Gorski JC, Huang SM, Pinto A, Hamman MA, Hilligoss JK, Zaheer NA, Desai M, Miller M, Hall SD (2004) The effect of Echinacea (Echinacea purpurea root) on cytochrome P450 activity in vivo. Clin Pharmacol Ther 75(1):89–100PubMedGoogle Scholar
  47. 47.
    Freeman C, Spelman K (2008) A critical evaluation of drug interactions with Echinacea spp. Mol Nutr Food Res 52(7):789–98PubMedGoogle Scholar
  48. 48.
    Hansen TS, Nilsen OG (2008) In vitro CYP3A4 metabolism: inhibition by Echinacea purpurea and choice of substrate for the evaluation of herbal inhibition. Basic Clin Pharmacol Toxicol 103(5):445–9PubMedGoogle Scholar
  49. 49.
    Heinrich M, Modarai M, Kortenkamp A (2008) Herbal extracts used for upper respiratory tract infections: are there clinically relevant interactions with the cytochrome P450 enzyme system? Planta Med 74(6):657–60PubMedGoogle Scholar
  50. 50.
    Medline plus, a service of the U.S. National Library of Medicine and the National Institutes of Health (update as of January 1, 2008)Google Scholar
  51. 51.
    Cordier H (2003) Verschnupftes Kind Ein Fall für “Schwarzen Holunder” (Child stuffed up with a cold. A case for black elder). Münchner Med Wochenzeits Fortschr Med 145(15):12Google Scholar
  52. 52.
    Roxas M and Jurenka J (2007) Colds and inffluenza: a review of diagnosis and conventional, botanical, and nutritional considerations. Altern Med Rev 12(1): 25–48PubMedGoogle Scholar
  53. 53.
    Knox Y M, Hayashi K, Suzutani T, Ogasava M, Yoshida I, Shiina R, Tsukui A, Terahara N, Azuma M (2001) Activity of anthocyanins from fruit extract of Ribes nigrum L. against influenza A and B viruses. Acta Virol. 45 (4), 209–215PubMedGoogle Scholar
  54. 54.
    Zakay-Rones Z, Thom E, Wollan T, Wadstein J. Randomized study of the efficacy and safety of oral elderberry extract in the treatment of influenza A and B virus infections. J Int Med Res. 32(2):132–140;(2004)PubMedGoogle Scholar
  55. 55.
    Zakay-Rones Z, Varsano N, Zlotnik M, Manor O, Regev L, Schlesinger M, Mumcuoglu M (1995) Inhibition of several strains of influenza virus in vitro and reduction of symptoms by an elderberry extract (Sambucus nigra L) during an outbreak of influenza B Panama. J Altern Complement Med 1 (4): 361–369PubMedGoogle Scholar
  56. 56.
    Anon. (2005) Monograph Sambucus nigra (Elderberry). Alternative medicine review 10 (1): 51–55Google Scholar
  57. 57.
    Foerster-Waldl E., M. Marchetti, I. Schoell, M. Focke, C. Radauer, T. Kinaciyan, I. Nentwich, S. Jaeger, E. R. Schmid, G. Boltz-Nitulescu et al. (2003) Type I allergy to elderberry (Sambucus nigra) is elicited by a 33.2 kDa allergen with significant homology to ribosomal inactivating protein. Clin Exp Allergy 33 (12) 1703–10Google Scholar
  58. 58.
    Amagase H (2006) Clarifying the real bioactive constituents of garlic. J Nutr 136 (3 Suppl):716–725Google Scholar
  59. 59.
    Ivker RS (2002) Respiratory disease — sinusitis, upper respiratory infection otitis media. Clinics in family practice 4 (4):929–946Google Scholar
  60. 60.
    Abdullah T (2000) A strategic call to utilize Echinacea-garlic in flu-cold seasons. J Nat Med Association 92 (1):48–51Google Scholar
  61. 61.
    Josling P (2001) Preventing the common cold with a garlic supplement.; a double-blind, placebo controlled study. Adv Ther 18(4):189–193PubMedGoogle Scholar
  62. 62.
    Andrianova IV, Sobenin IA, Sereda EV, Borodina LI, Studenikin MI (2003) Effect of long-acting garlic tablets “allicor” on the incidence of acute respiratory viral infections in children. Ther Arkh 75 (3):53–56Google Scholar
  63. 63.
    Shamseer L, Charrois TL, Vohra S (2006) Complementary, holistic and integrative medicine: garlic. Pediatr Rev 27:77–80Google Scholar
  64. 64.
    Hiltunen R, Josling PD, James MH (2007) Preventing airborne infection with an intranasal cellulose powder formulation (Nasaleze travel). Adv Ther 24 (5):1146–53PubMedGoogle Scholar
  65. 65.
    Pittler MH, Ernst E (2007) Clinical effectiveness of garlic (Allium sativum). Mol Nutr Food Res 51(11):1382–1385PubMedGoogle Scholar
  66. 66.
    Anon (2008) Herbs and Supplements — Garlic. Copyright © 2008 EBSCO Publishing; last reviewed November 2008 by EBSCO CAM Review Board. Accessed Dec. 14, 2008Google Scholar
  67. 67.
    Bielory L (2004) Complementary and alternative interventions in asthma, allergy, and immunology. Ann Allergy Asthma Immunol 93 (2 Suppl 1):45–54CrossRefGoogle Scholar
  68. 68.
    Schulz V, Hansel R, Tyler VE (1998) Rational Phytotherapy: A Physicians’ Guide to Herbal Medicine. 3rd ed. Berlin, Germany: Springer-Verlag; 121Google Scholar
  69. 69.
    Scott GN and Elmer GW (2002) Update on natural product-drug interactions. Am J Health Syst Pharm 59(4):339–47PubMedGoogle Scholar
  70. 70.
    Scharbert G, Kalb ML, Duris M, Marschalek C, Kozek-Langenecker SA (2007) Garlic at dietary doses does not impair platelet function. Anesth Analg 105(5):1214–8PubMedGoogle Scholar
  71. 71.
    Hu Z, Yang X, Ho PC, Chan SY, Heng PW, Chan E, Duan W, Koh HL, Zhou S (2005) Herb-drug interactions: a literature review. Drugs 65(9):1239–82PubMedGoogle Scholar
  72. 72.
    Macan H, Uykimpang R, Alconcel M, Takasu J, Razon R, Amagase H, Niihara Y (2006) Aged garlic extract may be safe for patients on warfarin therapy. J Nutr 136(3):793–95Google Scholar
  73. 73.
    Aimbire F, Penna SC, Rodrigues M, Rodrigues KC, Lopes-Martins RA, Sertie JA (2007) Effect of hydroalcoholic extract of Zingiber officinalis rhizomes on LPS-induced rat airway hyperreactivity and lung inflammation. Prostaglandins Leukot Essent Fatty Acids 77 (3–4):129–138PubMedGoogle Scholar
  74. 74.
    Ghayur MN, Gilani AH, Janssen LJ (2008) Ginger attenuates acetylcholine-induced contraction and Ca+ signalling in murine airway smooth muscle cells. Can J Physiol Pharmacol 86 (5):264–271PubMedGoogle Scholar
  75. 75.
    Hong H, Yang F, Liu X-C, Yang y-Q (2006) Effect of shegan mahuang decoction on the changes of interleukin 5 and interleukin 10 in peripheral plasma of asthma guinea pigs. Chin J Clin Rehab 10(835):63–65Google Scholar
  76. 76.
    Park KJ, Lee HH (2005) In vitro antiviral activity of aqueous extract from Korean medicinal plants against influenza virus type A. J Microbiol Biotechnol 15(5):924–929Google Scholar
  77. 77.
    Imanishi N, Andoh T, Mantani N, Sakai S, Terasawa K, Shimada Y, Sato M, Katada Y, Ueda K, Ochiai H (2006) Macrophage-mediated inhibitory effect of Zingiber officinale Rosc., a traditional Oriental herbal medicine, on the growth of influenza A/Aichi/2/68 virus. Am J Chin Med 34(1):157–169PubMedGoogle Scholar
  78. 78.
    Srivastava KC (1984) Aqueous extracts of onion, garlic and ginger inhibit platelet aggregation and alter arachidonic acid metabolism. Biomed Biochim Acta (Berlin) 43 (8/9):335–346Google Scholar
  79. 79.
    Srivastava KC (1986) Isolation and effects of some ginger components on platelet aggregation and eicosanoid biosynthesis. Prostaglandins Leukot Essent Fatty Acids 35:183–185Google Scholar
  80. 80.
    Weidner MS, Sigwart K (2000) The safety of a ginger extract in the rat. J Ethnopharmacol 73:513–520PubMedGoogle Scholar
  81. 81.
    Kruth P, Brossi E, Fux R (2004) Ginger-associated over anticoagulation by phenprocoumon. Acta Pharmacother 38:257–260Google Scholar
  82. 82.
    Mascolo N, Jain R, Jain SC, Capasso F (1989) Ethnopharmacologic investigation of ginger. J Ethnopharmacol 27:129–140PubMedGoogle Scholar
  83. 83.
    Bordia A, Verma SK, Srivastava KC (1997) Effect of ginger and fenugreek on blood lipids, blood sugar and platelet aggregation in patients with coronary artery disease. Prostaglandins Leukotrienes and Essential Fatty Acids 56 (5):379–384Google Scholar
  84. 84.
    Mukhopadhyay M, Mukherjee A (2000) Clastogenic effect of ginger rhizome in mice. Phytother Res 14:555–557PubMedGoogle Scholar
  85. 85.
    Erkan ML, Findik S, Tatlisoez H, Ugurlu D, Atici AG (2000) A new etiology of occupational asthma: rhizoma zingiberis. Ondokuz Mayis Univ Tip Derg 17(3):184–186Google Scholar
  86. 86.
    Pfeiffer WF (2005) A multicultural approach to the patient who has common cold. Pediatrics in review 26(5):170–175PubMedGoogle Scholar
  87. 87.
    McElhaney JE, Goel V, Toane B, Hooten J, Shan JJ (2006) Efficacy of Cold-fX in the prevention of respiratory symptoms in community-dwelling adults; a randomized double-blinded, placebo-controlled trial. J Altern Complement Med 12(2):153–157PubMedGoogle Scholar
  88. 88.
    Predy GN, Goel V, Lovlin R, Donner A, Stitt L, Basu TK (2005) Efficacy of an extract of North American ginseng containing poly-furanosyl-pyranosyl-saccharides for preventing upper respiratory tract infections: a randomized controlled study. Can Med Association J 173(9):1043–48Google Scholar
  89. 89.
    McElhaney JE, Gravenstein S, Cole SK, Davidson E, O’Neill D, Petitjean S, Rumble B, Shan JJ (2004) A placebo-controlled trial of a proprietary extract of North American ginseng (CVT-E002) to prevent acute respiratory illness in institutionalized older adults. J Am Geriatr Soc 52(1):13–19PubMedGoogle Scholar
  90. 90.
    Scaglione F, Cattaneo G, Alessandria M, Cogo R (1996) Efficacy and safety of the standardised Ginseng extract G115 for potentiating vaccination against the influenza syndrome and protection against the common cold. Drugs Exp Clin Res 22(2):65–72PubMedGoogle Scholar
  91. 91.
    Vuksan V, Sievenpiper JL, Koo VY, Francis T, Beljan-Zdravkovic U, Xu Z, Vidgen E (2000) American ginseng (Panax quinquefolium L) reduces post-prandial glycemia in nondiabetic subjects and subjects with type 2 diabetes mellitus. Arch Intern Med 160(7):1009–13PubMedGoogle Scholar
  92. 92.
    Scaglione F, Ferrara F, Dugnani S, Falchi M, Santoro G, Fraschini F (1990) Immunomodulatory effects of two extracts of Panax ginseng C.A. Meyer. Drugs Exp Clin Res 16(10):537–42PubMedGoogle Scholar
  93. 93.
    Wang M, Guilbert LJ, Ling L, Li J, Wu Y, Xu S, Pang P, Shan JJ (2001) Immunomodulating activity of CVT-E002, a proprietary extract from North American ginseng (Panax quinquefolium). J Pharm Pharmacol 53(11):1515–1523PubMedGoogle Scholar
  94. 94.
    Wang M, Guilbert LJ, Li J, Wu Y, Pang P, Basu TK, Shan JJ (2004) A proprietary extract from North American ginseng (Panax quinquefolium) enhances IL-2 and IFN-gamma productions in murine spleen cells induced by Con-A. J Am Geriatr Soc 52(1):13–19Google Scholar
  95. 95.
    Yuan CS, Wei G, Dey L, Karrison T, Nahlik L, Maleckar S, Kasza K, Ang-Lee M, Moss J (2004) Brief communication: American ginseng reduces warfarin’s effect in healthy patients: a randomized, controlled trial. Ann Inten Med 141(1):23–7Google Scholar
  96. 96.
    Rabbani GH, Butler T, Knight J, et al. (1987) Randomized controlled trial of berberine sulfate therapy for diarrhea due to enterotoxigenic Escherichia coli and Vibrio cholerae. J Infectious Dis 155(5):979–984Google Scholar
  97. 97.
    Hwang BY, Roberts SK, Chadwick LR, Wu CD, Kinghorn AD (2003) Antimicrobial constituents from goldenseal (the Rhizomes of Hydrastis canadensis) against selected oral pathogens. Planta Med 69(7):623–27PubMedGoogle Scholar
  98. 98.
    Anon (2000) Berberine Monograph. Alternative Medicine Review 5 (2):175–177Google Scholar
  99. 99.
    Ckless K, Schlottfeldt JL, Pasqual M, Moyna P, Henriques JA, Wajner M (1995) Inhibition of in-vitro lymphocyte transformation by the isoquinoline alkaloid berberine. J Pharm Pharmacol 47 (12a):1029–31PubMedGoogle Scholar
  100. 100.
    Huang CG, Chu ZL, Yang ZM (1991) Effects of berberine on synthesis of platelet TXA2 and plasma PGI2 in rabbits. Chung Kuo Yao Li Hsueh Pao 12:526–528PubMedGoogle Scholar
  101. 101.
    Hawkins EB, Ehrlich SD: Goldenseal: online review University of Maryland, Medical Center review date: 1/24/2007Google Scholar
  102. 102.
    Bedard, M (2002) Goldenseal: high on promises, low on evidence. Can Pharm J 135 (9):44–48Google Scholar
  103. 103.
    Palanisamy A, Haller C, Olson KR (2003) Photosensitivity reaction in a woman using an herbal supplement containing ginseng, goldenseal and bee pollen. J Toxicol Clin Toxicol 41 (6):865–7PubMedGoogle Scholar
  104. 104.
    Chichon PG (2000) Herbs and the common cold. Evidence for nurse practitioners 31–32, August 2000Google Scholar
  105. 105.
    Mills Simon, Bone Kerry (2000) Principles and Practice of Phytotherapy. Philadelphia, Churchill Livingstone (cited by Hawkins and Ehrlich)Google Scholar
  106. 106.
    Yao M, Ritchie HE, Brown-Woodman PD (2005) A reproductive screening test of goldenseal. Birth Defects Res B Dev Reprod Toxicol 74(5):399–404PubMedGoogle Scholar
  107. 107.
    Jahnke GD, Price CJ, Marr MC, Myers CB, George JD (2006) Developmental toxicity evaluation of berberine in rats and mice. Birth Defects Res B Dev Reprod Toxicol 77(3):195–206PubMedGoogle Scholar
  108. 108.
    Sandhu RS, Prescilla RP, Simonelli TM, Edwards DJ (2003) Influence of goldenseal root on the pharmacokinetics of indinavir. J Clin Pharmacol 43(11):1283–88PubMedGoogle Scholar
  109. 109.
    Büechi S, Voegelin R, von Eiff MM, Ramos M, Melzer J (2005) Open trial to assess aspects of safety and efficacy of a combined herbal cough syrup with ivy and thyme. Forsch Komplemetärmed Klass Naturheilkunde 12 (6):328–333Google Scholar
  110. 110.
    Büechi S and Kähler D (2003) Efeu (Hedera helix) bei Atemwegserkrankungen. Eine offene Studie mit Efeu Pastillen (Ivy (Hedera helix) for respiratory tract infections. An open study with ivy pastilles). Schweiz Zschr Ganzheits Medizin 15, 125–128Google Scholar
  111. 111.
    Mansfeld HJ, Höhre H, Repges R, Dethlefsen U (1998) Therapie des Asthma bronchiale mit Efeublätter-Trockenextrakt (Therapy of asthma bronchiale with ivy leaf dry extract). Münchner Med Wochenzeits Fortschr Med 140:26–30Google Scholar
  112. 112.
    Hecker M, Runkel F, Voelp A (2002) Treatment of chronic bronchitis with ivy special extract — multicenter post-marketing surveillance study in 1350 patients. Forsch Komplementärmed Klass Naturheilkunde 9 (2):77–84Google Scholar
  113. 113.
    Anon (2004) Präparate aus der Efeupflanze lindern lästigen Husten: Molekularer Wirkmechanismus entschlüsselt (Preparations from ivy plants relieve troublesome cough: Molecular mechanism of action deciphered). Ärztez für Naturheilverfahren 45 (2):84–86Google Scholar
  114. 114.
    De Mello FB, De Mello JRB (2006) Evaluation of antitussive/expectorant effects of two phytotherapeutic formulations existent in the Brazilian market. Acta Farm Bonaer 25 (1):64–70Google Scholar
  115. 115.
    Hrastinger A, Dietz B, Bauer R, Sagraves R, Mahady G (2005) Is there clinical evidence supporting the use of botanical dietary supplements in children? J Pediatr. 146:311–317PubMedGoogle Scholar
  116. 116.
    Wagner L (2004) Die gesundheitliche Wirkung von Bienenerzeugnissen (The health effect of bee products). Naturheilpraxis 57(4):533–537Google Scholar
  117. 117.
    Paul IM, Beiler J, McMonagle A, Shaffer ML, Duda L, Berlin CM Jr (2007) Effect of honey, dextromethorphan, and no treatment on nocturnal cough and sleep quality for coughing children and their parents. Arch Pediatr Adolesc Med 161(12):1140–1146PubMedGoogle Scholar
  118. 118.
    Warren MD, Pont SJ, Barkin SL, Callahan ST, Caples L, Carroll KN, Plemmons GS, Swan RR, Cooper WO (2007) The effect of honey on nocturnal cough and sleep quality for children and their parents. Arch Pediatr Adolesc Med 161(12):1149–1153PubMedGoogle Scholar
  119. 119.
    Hellner M, Winter D, von Georgi R, Münstedt K (2007) Apitherapy: Usage And Experience In German Beekeepers. eCAM Advance Access published June 30, 2007, doi:10.1093/ecam/nem052Google Scholar
  120. 120.
    Frawley D (2005) Das große Ayurveda-Heilungsbuch — Prinzipien und Praxis (Ayurvedic healing: a comprehensive guide, Lotus Press). Knaur MensSanaGoogle Scholar
  121. 121.
    Bellavite P, Ortolani R, Pontarollo F, Piasere V, Benato G and Conforti A (2006) Immunology and Homeopathy. 4. Clinical Studies — Part 1. Evid Based Complement Alternat Med 3(3):293–301PubMedGoogle Scholar
  122. 122.
    Lecoq PL (1985) L-52. Les voies thérapeuthiques des syndromes grippaux. Cah Biothér 87:65–73.Google Scholar
  123. 123.
    Heilmann A (1994) A combination injection preparation as a prophylactic for flu and common colds. Biol Ther 13:249–53Google Scholar
  124. 124.
    Steinsbekk A, Bentzen N, Fonnebo V, Lewith G (2005) Self treatment with one of three self selected, ultramolecular homeopathic medicines for the prevention of upper respiratory trast infections in children. A double-blind randomized placebo controlled trial. Br J Clin Pharmacol 59:447–55PubMedGoogle Scholar
  125. 125.
    de Lange de Klerk ES, Blommers J, Kuik DJ, Bezemer PD, Feenstra L (1994) Effect of homoeopathic medicines on daily burden of symptoms in children with recurrent upper respiratory tract infections. BMJ 309(6965):1329–32PubMedGoogle Scholar
  126. 126.
    Gassinger CA, Wunstel G, Netter P (1981) A controlled clinical trial for testing the efficacy of the homeopathic drug Eupatorium perfoliatum D2 in the treatment of common cold. Arzneimittelforschung 31:732–6PubMedGoogle Scholar
  127. 127.
    Maiwald VL, Weinfurtner T, Mau J, Connert WD (1988) Treatment of common cold with a combination homeopathic preparation compared with acetylsalicylic acid. A controlled, randomized single-blind study. Arzneimittelforschung 38:578–582PubMedGoogle Scholar
  128. 128.
    Steinsbekk A, Fonnebo V, Lewith G, Bentzen N (2005) Homeopathic care for the prevention of upper respiratory tract infections in children: a pragmatic, randomised, controlled trial comparing individualised homeopathic care and waiting-list controls. Complement Ther Med 13:231–8PubMedGoogle Scholar
  129. 129.
    Riley D, Fischer M, Singh B, Haidvogl M, Heger M (2001) Homeopathy and conventional medicine: an outcomes study comparing effectiveness in a primary care setting. J Altern Complement Med 7:149–59PubMedGoogle Scholar
  130. 130.
    Rabe A, Weiser M, Klein P (2004) Effectiveness and tolerability of a homoeopathic remedy compared with conventional therapy for mild viral infections. Int J Clin Pract 58(9):827–32PubMedGoogle Scholar
  131. 131.
    Danheisser I, Edwards P (1999) Homöopathie — Sanfte Wege zur Gesundheit. Könemann Verlagsgesellschaft mbH (Originalausgabe: Homeopathy, an Illustrated Guide, element Books Ltd., 1998)Google Scholar
  132. 132.
    Homöopathisches Repetitorium, Ausgabe 2007. Deutsche Homöopathie-Union KarlsruheGoogle Scholar
  133. 133.
    Leibold G (2004) Schüßler-Salze, Oesch/Jopp Verlag, Zürich, 1. Auflage 2004Google Scholar
  134. 134.
    Anon (2008) Ferrum phosphoricum Epub, lexikon-der-schüsslersalze.de, Nr.3 ferrum phosphoricum, accessed Dec 23, 2008Google Scholar
  135. 135.
    Rother C (2007) Efficacy and tolerance of the anthroposophical remedy Ferrum phosphoricum comp (Infludoron) for beginning and advanced common cold Epub www.anthromed.org, accessed Dec.23, 2008Google Scholar
  136. 136.
    Bischko J (1994) Einführung in die Akupunktur (an introduction to acupuncture) Band I, 16. Auflage, Karl F. Haug Verlag, HeidelbergGoogle Scholar
  137. 137.
    Bischko J (1980) Akupunktur für mässig Fortgeschrittene (acupuncture for moderate advanced practitioners) Band II, Textband, 2. Auflage, Karl F. Haug Verlag, HeidelbergGoogle Scholar
  138. 138.
    Javasuriya A, Hühne U (1986) Klinische Akupunktur (clinical acupuncture) Ulrich-Hühne-Verlag, Colombo, Vertrieb: Karl F. Haug Verlag, Heidelberg, GermanyGoogle Scholar
  139. 139.
    Wertsch, Schrecke, Küstner (1986) Akupunkturatlas (Acupuncture Atlas) 6. Auflage, WBV Biologisch-Medizinische Verlagsgesellschaft mbH & Co KG, Schondorf, GermanyGoogle Scholar
  140. 140.
    Kawakita K, Shichidou T, Inoue E, Nabeta T, Kitakouji H, Aizawa S, Nishida A, Yamaguchi N, Takahashi N, Yano T, Tanzawa S (2004) Preventive and curative effects of acupuncture on the common cold: a multicentre randomized controlled trial in Japan. Complement Ther Med 12:181–188PubMedGoogle Scholar
  141. 141.
    Kawakita K, Shichidou T, Inoue E, Nabeta T, Kitakoji H, Aizawa S, Nishida A, Yamaguchi N, Takahashi N, Sumiya E et al. (2008) Do Japanese style acupuncture and moxibustion reduce symptoms of the common cold? Evid Based Complement Alternat Med 5:481–489PubMedGoogle Scholar
  142. 142.
    Ody, Penelope (2000) Practical Chinese medicine. Godsfield Press Ltd, German edition 2001 by Urania Verlag AG, Neuhausen/SwitzerlandfGoogle Scholar
  143. 143.
    Hin, Dr. Kuan (1992) Chinesische Massage und Akupressur (Chinese massage and acupressure) 2. erweiterte Auflage 1992, Hallwag Verlag Bern und StuttgartGoogle Scholar
  144. 144.
    Neumaier J (2004) Kasse propagiert Nasenspülungen — Billiges Rezept gegen Erkältungen. MMW-Fortschritte der Medizin Nr. 3–4, S. 16Google Scholar
  145. 145.
    Papsin B, A McTrevish (2003) Saline nasal irrigation: Its role as an adjuvant treatment. Can Fam Physician 49:168–73PubMedGoogle Scholar
  146. 146.
    Rabago D, Pasic T, Zgierska A, Mundt M, Barrett B, Maberry R (2005) The efficacy of hypertonic saline nasal irrigation for chronic sinonasal symptoms. Otolaryngology Head and Neck Surgery 133 (1):3–8PubMedGoogle Scholar
  147. 147.
    Leibold G (2002) Erkältung und Grippe. Hilfe durch bewährte Naturheilverfahren (Common cold and flu. Help through reliable alternative therapies). Oesch Verlag Zurich (Jopp/Oesch Programm)Google Scholar
  148. 148.
    Ivker RS (2002) Respiratory disease — sinusitis, upper respiratory infection, otitis media. Clinics in family practice 4 (4):929–946Google Scholar

Copyright information

© Birkhäuser Verlag Basel/Switzerland 2009

Authors and Affiliations

  • Florin Mihail
    • 1
  1. 1.WuppertalGermany

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