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Erythropoietins, Erythropoietic Factors, and Erythropoiesis pp 155–174Cite as

Intracellular signaling by the erythropoietin receptor

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Part of the book series: Milestones in Drug Therapy ((MDT))

Abstract

The erythropoietin receptor (EPOR) is crucial for promoting the survival, proliferation, and differentiation of mammalian erythroid progenitors [1]. Differentiation from colony-forming units-erythroid (CFU-E) to late basophilic erythroblasts is highly EPO dependent, whereas differentiation beyond this stage is no longer dependent on EPO, but requires adhesion of the cells to a fibronectin matrix, through α4β1 integrin [2].

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Authors and Affiliations

  1. Whitehead Institute for Biomedical Research, Cambridge, MA

    Harvey F. Lodish

  2. Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA

    Harvey F. Lodish

  3. Department of Gene and Cell Medicine, Mount Sinal School of Medicine, New-York, NY, USA

    Saghi Ghaffari

  4. Department of Pediatrics and Department of Cancer Biology, University of Massachusetts Medical School, Worcester, MA, USA

    Merav Socolovsky

  5. Department of Pediatrics, University of Pennsylvania School of Medicine and Division of Hematology, Children’s Hospital of Philadelphia, Philadelphia, PA, USA

    Wei Tong

  6. McArdle Laboratory for Cancer Research, University of Wisconsin, Madison, WI, USA

    Jing Zhang

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    Steven G. Elliott

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Lodish, H.F., Ghaffari, S., Socolovsky, M., Tong, W., Zhang, J. (2009). Intracellular signaling by the erythropoietin receptor. In: Elliott, S.G., Foote, M.A., Molineux, G. (eds) Erythropoietins, Erythropoietic Factors, and Erythropoiesis. Milestones in Drug Therapy. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-8698-6_10

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