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Th 17 Cells: Role in Inflammation and Autoimmune Disease pp 39–48Cite as

Other sources of IL-17: Invariant natural killer T cells

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Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

Interleukin-17 (IL-17) plays a major role in various models of immune-mediated tissue injury, including organ-specific autoimmunity, allergic disorders and microbial infections. Th17 cells are currently the most thoroughly characterized source of IL-17 credited for causing and sustaining the tissue damage mediated by this cytokine. Similarly to their Th1 and Th2 counterpart, Th17 cells depend on specific factors for their differentiation from naïve T cell precursors, before acquiring their typical cytokine profile. However, this is not the case for all IL-17-producing cells, particularly for a subset of invariant natural killer T cells, termed iNKT17, which are ready to produce this cytokine immediately upon stimulation, in keeping with their capacity to intervene during early stages of the inflammatory response.

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Author information

Authors and Affiliations

  1. CNRS (Centre National de la Recherche Scientifique), UMR (Unité Mixte de Recherche) 8147, Faculté de Médecine René Descartes, Paris V, Hôpital Necker, 161 rue de Sèvres, 75743, Paris, Cedex 15, France

    Marie-Laure Miche & Maria C. Leite-de-Moraes

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  1. Marie-Laure Miche
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  2. Maria C. Leite-de-Moraes
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Editors and Affiliations

  1. Molecular Immunology and Embryology, University of Orléans and CNRS UMR6218, 45071, Orléans, France

    Valérie Quesniaux  & Bernhard Ryffel  & 

  2. Novartis Institutes for Biomedical Research, NIBR WSJ 386-906, 4002, Basel, Switzerland

    Franco Di Padova

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© 2009 Birkhäuser Verlag Basel/Switzerland

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Miche, ML., Leite-de-Moraes, M.C. (2009). Other sources of IL-17: Invariant natural killer T cells. In: Quesniaux, V., Ryffel, B., Di Padova, F. (eds) Th 17 Cells: Role in Inflammation and Autoimmune Disease. Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-8681-8_3

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  • DOI: https://doi.org/10.1007/978-3-7643-8681-8_3

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-7643-8680-1

  • Online ISBN: 978-3-7643-8681-8

  • eBook Packages: MedicineMedicine (R0)

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