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Th17 cells in organ transplantation

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Book cover Th 17 Cells: Role in Inflammation and Autoimmune Disease

Part of the book series: Progress in Inflammation Research ((PIR))

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Abstract

A newly discovered subset of T helper cells, Th17 cells, has been implicated in a number of models of autoimmunity. However, their role in transplantation remains undefined. This is despite studies showing a link between IL-17, a cytokine secreted by Th17 cells, and acute allograft rejection. This chapter summarises current evidence for a role of Th17 cells in transplant rejection, tolerance and ischaemia reperfusion injury.

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Author information

Authors and Affiliations

  1. Sir William Dunn School of Pathology, University of Oxford, Oxford, UK

    Ye Chen

  2. Transplantation Research Immunology Group, Nuffield Department of Surgery, University of Oxford, Oxford, UK

    Kathryn J. Wood

Authors
  1. Ye Chen
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  2. Kathryn J. Wood
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Editor information

Editors and Affiliations

  1. Molecular Immunology and Embryology, University of Orléans and CNRS UMR6218, 45071, Orléans, France

    Valérie Quesniaux  & Bernhard Ryffel  & 

  2. Novartis Institutes for Biomedical Research, NIBR WSJ 386-906, 4002, Basel, Switzerland

    Franco Di Padova

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© 2009 Birkhäuser Verlag Basel/Switzerland

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Chen, Y., Wood, K.J. (2009). Th17 cells in organ transplantation. In: Quesniaux, V., Ryffel, B., Di Padova, F. (eds) Th 17 Cells: Role in Inflammation and Autoimmune Disease. Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-8681-8_11

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  • DOI: https://doi.org/10.1007/978-3-7643-8681-8_11

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-7643-8680-1

  • Online ISBN: 978-3-7643-8681-8

  • eBook Packages: MedicineMedicine (R0)

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