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Modelling Vaccine Protocols

  • Santo Motta
  • Pier-Luigi Lollini
  • Francesco Pappalardo
Chapter
  • 995 Downloads
Part of the Mathematics and Biosciences in Interaction book series (MBI)

Abstract

Living organisms are natural complex systems where mathematical modelling may play a crucial role, since a model can be built with imperfect knowledge of some related phenomenon and model parameters (initial data, entities, relations between entities) can be adjusted to fit modelling results to experimental measurements. The model can then be used to understand the general behaviour of the phenomenon in different situations, to perform model experiments or simulations, to understand the role of single constituents and relations, to plan new experiments, or to test theoretical assumptions and suggest theory modifications. Modelling can therefore stimulate scientific creativity and produce better theoretical descriptions of the reality. We describe here our efforts to devise models of the immune system, and in particular the competition between immune defences and tumor cells. An agent-based model of the effects of a vaccine designed to prevent mammary carcinoma incidence in transgenic mice was developed. This model faithfully summarises not only the outcome of vaccination experiments, but also the dynamics of immune responses elicited by the vaccine. A genetic algorithm was used to drive the model and predict optimised vaccination schedules, which are currently being tested in vivo. The implications of biologic diversity on model development and perspectives to develop natural-scale models of the immune system are also discussed.

Keywords

Cancer vaccine model simulator 

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Copyright information

© Birkhäuser Verlag Basel/Switzerland 2008

Authors and Affiliations

  • Santo Motta
    • 1
  • Pier-Luigi Lollini
    • 2
  • Francesco Pappalardo
    • 1
  1. 1.Dipartimento di Mathematica e InformaticaCataniaItaly
  2. 2.Department of Experimental PathologyLaboratory of Immunology and Biology of Metastasis, Cancer Research SectionBolognaItaly

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