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Bone morphogenetic proteins in cartilage biology

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Bone Morphogenetic Proteins: From Local to Systemic Therapeutics

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

Cartilage repair and regeneration is a major obstacle in orthopedic medicine. The importance is enormous since osteoarthritis (OA) is a major cause of disability among the adult population in the United States and degenerative disc disease (DDD) is responsible for a significant amount of the chronic back pain. OA is considered a process of attempted, but gradually failing, repair of damaged cartilage extracellular matrix, as the balance between synthesis and breakdown of matrix components is disturbed and shifted towards catabolism. In recent times, members of the bone morphogenetic protein (BMP) family of proteins have demonstrated a great potential as anabolic factors for cartilage repair because of their ability to induce matrix synthesis and promote repair in cartilage.

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Authors and Affiliations

  1. Department of Biochemistry, Rush University Medical Center, Chicago, IL, 60612, USA

    Susan Chubinskaya

  2. Guelph University, Guelph, Ontario, Canada

    Mark Hurtig

  3. Stryker Biotech Division, Hopkinton, MA, 01748, USA

    David C. Rueger

Authors
  1. Susan Chubinskaya
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  2. Mark Hurtig
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  3. David C. Rueger
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Editors and Affiliations

  1. School of Medicine Inst. Anatomy Drago Perovic, University of Zagreb, Salata 11, 10000, Zagreb, Croatia

    Slobodan Vukicevic

  2. Genzyme Corporation, One Mountain Road, Framingham, MA, 01701-9322, USA

    Kuber T. Sampath

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© 2008 Birkhäuser Verlag Basel/Switzerland

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Chubinskaya, S., Hurtig, M., Rueger, D.C. (2008). Bone morphogenetic proteins in cartilage biology. In: Vukicevic, S., Sampath, K.T. (eds) Bone Morphogenetic Proteins: From Local to Systemic Therapeutics. Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-8552-1_15

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  • DOI: https://doi.org/10.1007/978-3-7643-8552-1_15

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-7643-8551-4

  • Online ISBN: 978-3-7643-8552-1

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