Skip to main content
SpringerLink
Log in

The role and mechanisms of bone morphogenetic protein 4 and 2 (BMP-4 and BMP-2) in postnatal skeletal development

  • Chapter
Bone Morphogenetic Proteins: From Local to Systemic Therapeutics

Part of the book series: Progress in Inflammation Research ((PIR))

  • 979 Accesses

Abstract

This paper is dedicated to Holger Kulessa who developed the BMP-4 floxed mouse model used in these studies.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Hogan BL (1996) Bone morphogenetic proteins: multifunctional regulators of vertebrate development. Genes Dev 10: 1580–1594

    Article  CAS  Google Scholar 

  2. Harris SE, Bonewald LF, Harris MA, Sabatini M, Dallas S, Feng JQ, Ghosh-Choudhury N, Wozney J, Mundy GR (1994) Effects of transforming growth factor beta on bone nodule formation and expression of bone morphogenetic protein 2, osteocalcin, osteopontin, alkaline phosphatase, and type I collagen mRNA in long-term cultures of fetal rat calvarial osteoblasts. J Bone Miner Res 9: 855–863

    Article  CAS  Google Scholar 

  3. Abrams KL, Xu J, Nativelle-Serpentini C, Dabirshahsahebi S, Rogers MB (2004) An evolutionary and molecular analysis of Bmp2 expression. J Biol Chem 279: 15916–15928

    Article  CAS  Google Scholar 

  4. Chen D, Ji X, Harris MA, Feng JQ, Karsenty G, Celeste AJ, Rosen V, Mundy GR, Harris SE (1998) Differential roles for bone morphogenetic protein (BMP) receptor type IB and IA in differentiation and specification of mesenchymal precursor cells to osteoblast and adipocyte lineages. J Cell Biol 142: 295–305

    Article  CAS  Google Scholar 

  5. Zhao M, Harris SE, Horn D, Geng Z, Nishimura R, Mundy GR, Chen D (2002) Bone morphogenetic protein receptor signaling is necessary for normal murine postnatal bone formation. J Cell Biol 157: 1049–1060

    Article  CAS  Google Scholar 

  6. Panchision DM, Pickel JM, Studer L, Lee SH, Turner PA, Hazel TG, McKay RD (2001) Sequential actions of BMP receptors control neural precursor cell production and fate. Genes Dev 15: 2094–2110

    Article  CAS  Google Scholar 

  7. Murali D, Yoshikawa S, Corrigan RR, Plas DJ, Crair MC, Oliver G, Lyons KM, Mishina Y, Furuta Y (2005) Distinct developmental programs require different levels of Bmp signaling during mouse retinal development. Development 132: 913–923

    Article  CAS  Google Scholar 

  8. Bandyopadhyay A, Tsuji K, Cox K, Harfe BD, Rosen V, Tabin CJ (2006) Genetic analysis of the roles of BMP2,4, and 7 in limb patterning and skeletogenesis. PLOS 2: 2116–2130

    CAS  Google Scholar 

  9. Styrkarsdottir U, Cazier J, Rolfsson O, Larsen H, Bjarnadottir E, Johannsdottir, Sigurdardottir, Jonasson K, Frigge ML, Kong A et al (2003) The bone morphogenetic protein 2 gene contributes to bone density and osteoporotic fractures. J Bone Miner Res 18(Suppl 2): s23

    Google Scholar 

  10. Ichikawa S, Koller DL, Johnson ML, Lai D, Johnston CC, Hui SL, Foroud TM, Peacock M, Econs MJ (2004) Polymorphisms in the bone morphogenetic protein 2 (BMP2) gene do not affect peak bone mineral density in men and women. J Bone Miner Res 19(Suppl 1): s249

    Google Scholar 

  11. Hsu Y, Zhang Y, Xu X, Feng Y, Terwexdow H, Zhang T, Wu D, Tang G, Li Z, Hong X et al (2004) Genetic variation in ALOX15, BMP2, PPARr and IGF1 gene is associated with BMD. J Bone Miner Res 19(Suppl 1): S386

    Google Scholar 

  12. Ramesh Babu L, Wilson SG, Dick IM, Islam FM, Devine A, Prince RL (2005) Bone mass effects of a BMP4 gene polymorphism in postmenopausal women. Bone 36: 555–561

    Article  CAS  Google Scholar 

  13. Winnier G, Blessing M, Labosky PA, Hogan BL (1995) Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse. Genes Dev 9: 2105–2116

    Article  CAS  Google Scholar 

  14. Kulessa H, Hogan BL (2002) Generation of a loxP flanked bmp4loxP-lacZ allele marked by conditional lacZ expression. Genesis 32: 66–68

    Article  CAS  Google Scholar 

  15. Liu F, Woitge HW, Braut A, Kronenberg MS, Lichtler AC, Mina M, Kream BE (2004) Expression and activity of osteoblast-targeted Cre recombinase transgenes in murine skeletal tissues. Int J Dev Biol 48: 645–653

    Article  CAS  Google Scholar 

  16. Nagy A (2000) Cre recombinase: The universal reagent for genome tailoring. Genesis 26: 99–109

    Article  CAS  Google Scholar 

  17. Rossant J, McMahon A (1999) “Cre”-ating mouse mutants-a meeting review on conditional mouse genetics. Genes Dev 13: 142–145

    Article  CAS  Google Scholar 

  18. Kwan KM (2002) Conditional alleles in mice: Practical considerations for tissue-specific knockouts. Genesis 32: 49–62

    Article  CAS  Google Scholar 

  19. Harris SE, Guo D, Yang W, Harris M, Gluhak-Heinrich J, Edwards J, Zhao M, Mundy GR, Anderson HC, Kream B et al (2006) BMP2 and BMP4 action and signaling in bone: Conditional deletion studies in mice. In: Abstracts of the 6th International Conference on BMPs 2006, 28–116

    Google Scholar 

  20. Chen X-D, Dusevich V, Feng JQ, Manolagas SC, Jilka RL (2007) Extracellular matrix made by bone marrow cells facilitates expansion of marrow-derived mesenchymal progenitor cells and prevents their differentiation into osteoblasts. J Bone Miner Res 22: 1943–1956

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. University of Texas Health Science Center at San Antonio, San Antonio, TX, 7703 Floyd Curl Dr., 78229, USA

    Stephen E. Harris, Wuchen Yang, Jelica Gluhak-Heinrich, Dayong Guo, Xiao-Dong Chen & Marie A. Harris

  2. University of Missouri at Kansas City, KC, MO, 7703 Floyd Curl Dr., 64108, USA

    Dayong Guo

  3. Vanderbilt University, Nashville, TN, 37232, USA

    Holger Kulessa, Jianhong Zhang, Gregory R. Mundy & James Edwards

  4. Duke University, Durham, NC, 27708, USA

    Brigid L. M. Hogan

  5. University of Connecticut Medical Center, Farmington, CT, 06032, USA

    Alex Lichtler & Barbara E. Kream

  6. National Institute of Environmental Health Science, Research Triangle Park, NC, 27709, USA

    Jian Q. Feng & Yuji Mishina

Authors
  1. Stephen E. Harris
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Wuchen Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jelica Gluhak-Heinrich
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Dayong Guo
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Xiao-Dong Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Marie A. Harris
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Holger Kulessa
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Brigid L. M. Hogan
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Alex Lichtler
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Barbara E. Kream
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Jianhong Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Jian Q. Feng
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. Gregory R. Mundy
    View author publications

    You can also search for this author in PubMed Google Scholar

  14. James Edwards
    View author publications

    You can also search for this author in PubMed Google Scholar

  15. Yuji Mishina
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. School of Medicine Inst. Anatomy Drago Perovic, University of Zagreb, Salata 11, 10000, Zagreb, Croatia

    Slobodan Vukicevic

  2. Genzyme Corporation, One Mountain Road, Framingham, MA, 01701-9322, USA

    Kuber T. Sampath

Rights and permissions

Reprints and permissions

Copyright information

© 2008 Birkhäuser Verlag Basel/Switzerland

About this chapter

Cite this chapter

Harris, S.E. et al. (2008). The role and mechanisms of bone morphogenetic protein 4 and 2 (BMP-4 and BMP-2) in postnatal skeletal development. In: Vukicevic, S., Sampath, K.T. (eds) Bone Morphogenetic Proteins: From Local to Systemic Therapeutics. Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-8552-1_10

Download citation

  • DOI: https://doi.org/10.1007/978-3-7643-8552-1_10

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-7643-8551-4

  • Online ISBN: 978-3-7643-8552-1

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation