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Influenza virus: The biology of a changing virus

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Influenza Vaccines for the Future

Part of the book series: Birkhäuser Advances in Infectious Diseases ((BAID))

Abstract

Recent discoveries in the field of influenza virology are the focus of this chapter. Influenza viruses are members of the family Orthomyxoviridae and include influenza virus types A, B, and C. This introduction provides a detailed overview of influenza virus classification, structure, and life cycle. We also include a brief review of the clinical manifestations of influenza and the molecular determinants for virulence. The genetic diversity of influenza A viruses and their capability to successfully infect an array of hosts, including avian and mammalian species, is highlighted in a discussion about host range and evolution. The importance of viral receptor-binding hemagglutinins and host sialic acid distribution in species-restricted binding of viruses is underscored. Finally, recent advances in our understanding of the seasonality and transmission of influenza viruses are described and their importance for the control of the spread of these viruses discussed.

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Authors and Affiliations

  1. Department of Microbiology, Mount Sinai School of Medicine, New York, NY, 10029, USA

    Samira Mubareka & Peter Palese

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  1. Samira Mubareka
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  2. Peter Palese
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  1. Novartis Vaccines, Via Fiorentina 1, 53100, Siena, Italy

    Rino Rappuoli  & Giuseppe Del Giudice  & 

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Mubareka, S., Palese, P. (2008). Influenza virus: The biology of a changing virus. In: Rappuoli, R., Del Giudice, G. (eds) Influenza Vaccines for the Future. Birkhäuser Advances in Infectious Diseases. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-8371-8_2

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