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Myocardial Proteases and Matrix Remodeling in Acute Myocarditis and Inflammatory Cardiomyopathy

  • Chapter
Inflammatory Cardiomyopathy (DCMi)

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

Inflammatory cardiomyopathy (DCMi) is commonly induced and maintained by cardiotropic viruses, and is associated with left ventricular (LV) dysfunction accompanied by myocardial inflammatory cell infiltration and increased release of proinflammatory cytokines. Recent insights have revealed the pivotal role played by the disruption of the extracellular matrix (ECM) architecture, caused mainly by cytokine-driven post-translational modification. Fibrillar collagen turnover results from the equilibrium between synthesis and degradation. The imbalance of the matrix degrading system with induced expression of metalloproteinases (MMPs) and plasminogen activators, and with concomitantly reduced expression of the tissue inhibitors of MMPs, contributes to a pathological collagen turnover. This results in a loss of myocardial structural integrity and impairment of LV function. Interference with ECM regulatory mechanisms may be effective in preventing persistent virus-induced and cytokine-driven cardiac injury. Future investigations are warranted to elucidate the possible effects of established immunomodulatory treatment strategies on the expression, biological activity and architecture of ECM components.

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Authors and Affiliations

  1. Department of Cardiology and Pneumonology, CharitéCentrum 11 for Cardiovascular Medicine, Charité — Universitätsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200, Berlin, Germany

    Susanne Rutschow, Michel Noutsias & Matthias Pauschinger

  2. Department of Internal Medicine — Cardiology, University Hospital of Marburg and Giessen, Philipps-Universität Marburg, Baldinger Strasse 1, 35033, Marburg, Germany

    Michel Noutsias

  3. Department of Cardiology, Medizinische Klinik 8, Klinikum Nürnberg Süd, Breslauer Straße 201, 90471, Nürnberg, Germany

    Matthias Pauschinger

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  1. Susanne Rutschow
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  1. Department of Cardiology and Pneumology, Charité—Universitätsmedizin Berlin Campus Benjamin Franklin, Hinderburgdamm 30, 12200, Berlin, Germany

    Heinz-Peter Schultheiss  & Michel Noutsias  & 

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Rutschow, S., Noutsias, M., Pauschinger, M. (2010). Myocardial Proteases and Matrix Remodeling in Acute Myocarditis and Inflammatory Cardiomyopathy. In: Schultheiss, HP., Noutsias, M. (eds) Inflammatory Cardiomyopathy (DCMi). Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-8352-7_5

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