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Targeting oncostatin M in the treatment of rheumatoid arthritis

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New Therapeutic Targets in Rheumatoid Arthritis

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

Oncostatin M (OSM) is a pleiotropic cytokine with potential utility as a treatment for inflammatory arthritis. This pro-inflammatory cytokine is increased in the rheumatoid but not in the osteoarthritic joint. Strategies to block the actions of OSM for use in inflammatory arthritis are being developed and these show significant promise in murine models of disease. Targeting OSM may have a beneficial effect by inhibiting some of the mechanisms of joint destruction in rheumatoid arthritis, which may limit long-term disability in patients. The challenge now is to convert this potential into firm compounds that can be tested in the clinic.

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Author information

Authors and Affiliations

  1. Division of Inflammation, School of Clinical Sciences, University of Liverpool, University Hospital Aintree, Longmoor Lane, Liverpool, L9 7AL, UK

    Theresa C. Barnes & Robert J. Moots

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  1. Theresa C. Barnes
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  2. Robert J. Moots
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Editors and Affiliations

  1. Division of Clinical Immunology and Rheumatology EULAR & FOCIS Center of Excellence Academic Medical Center, University of Amsterdam, Meibergdreef 9, Room F4-218, 1105, AZ Amsterdam, The Netherlands

    Paul-Peter Tak

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© 2009 Birkhäuser Verlag Basel/Switzerland

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Barnes, T.C., Moots, R.J. (2009). Targeting oncostatin M in the treatment of rheumatoid arthritis. In: Tak, PP. (eds) New Therapeutic Targets in Rheumatoid Arthritis. Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-8238-4_10

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  • DOI: https://doi.org/10.1007/978-3-7643-8238-4_10

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-7643-8237-7

  • Online ISBN: 978-3-7643-8238-4

  • eBook Packages: MedicineMedicine (R0)

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