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Invasive fungal infections in children: advances and perspectives

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Pediatric Infectious Diseases Revisited

Part of the book series: Birkhäuser Advances in Infectious Diseases ((BAID))

Abstract

Invasive fungal infections are important causes of morbidity and mortality in immunocompromised children. The past two decades have seen a dramatic increase in both number and overall relevance of invasive fungal infections in the hospital. At the same time, however, improved microbiological and imaging techniques together with an increased awareness have shifted the diagnosis of fungal infections from the autopsy theatre to the bedside. Major advances have been made in the definition of fungal diseases, the algorithms of antifungal interventions, the design and implementation of clinical trials and the development of standardized in vitro susceptibility testing. Most importantly, however, an array of new antifungal agents has entered the clinical arena and has made antifungal therapy more safe, more effective, but also more complicated. This article reviews some unique features of invasive fungal infections in infants and children and provides an update on the pharmacology of antifungal therapeutics in the pediatric population.

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Authors and Affiliations

  1. Infectious Disease Research Program, Center for Bone Marrow Transplantation and Department of Pediatric Hematology/Oncology, University Children’s Hospital, Münster, Germany

    Andreas H. Groll

  2. Division of Infectious Diseases, Children’s Hospital Boston, Boston, Massachusetts, USA

    Julia Koehler

  3. Immunocompromised Host Section, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA

    Thomas J. Walsh

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  1. Andreas H. Groll
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  2. Julia Koehler
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  3. Thomas J. Walsh
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Editors and Affiliations

  1. Pediatric Infectious Diseases Department of General Pediatrics, University Children’s Hospital, Moorenstr. 5, 40225, Düsseldorf, Germany

    Horst Schroten

  2. Children’s Hospital HELIOS Klinikum, Witten-Herdecke University, Heusnerstr. 40, 42283, Wuppertal, Germany

    Stefan Wirth

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Groll, A.H., Koehler, J., Walsh, T.J. (2007). Invasive fungal infections in children: advances and perspectives. In: Schroten, H., Wirth, S. (eds) Pediatric Infectious Diseases Revisited. Birkhäuser Advances in Infectious Diseases. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-8099-1_16

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