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Adhesion Molecules: Function and Inhibition pp 71–95Cite as

P- and E-selectin

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Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

P- and E-selectin, commonly referred to as the “endothelial” selectins, were initially described and characterized in the mid-late 1980s. P-selectin was first identified in 1984, using antibodies raised against activated platelets [1, 2]. In these initial publications, P-selectin was described as a protein of molecular weight of approximately 140 000, which was not found on resting platelets, but showed up-regulated expression following activation with thrombin or other mediators. In a subsequent investigation, Stenberg et al. [3] referred to this protein as “granule membrane protein-140” (GMP-140) due to its localization in the a granules of unstimulated platelets. In this study, as well as another report by Berman et al. [4], P-selectin was shown to translocate from the a granules in platelets to the plasma membrane following activation. In this latter publication, P-selectin was termed “platelet activation-dependent granule-external membrane protein” (PADGEM; see Table 1 for a listing of the other common abbreviations and designations for P-and E-selectin). In 1989, this adhesion molecule was shown to be expressed on the surface of cultured human endothelial cells following stimulation with histamine, thrombin, C5b-9, and other activators, and stored in resting cells in the Weibel-Palade bodies [5–8]. During this same year, a cDNA for P-selectin was cloned, and sequence analysis suggested a cysteine-rich protein similar to that reported for a new endothelialexpressed protein termed ELAM-1 (endothelial leukocyte adhesion molecule-1; see below) [9, 10].

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  1. Department of Genetics, University of Alabama at Birmingham, Kaul Building 640A, 720 South 20th Street, Birmingham, AL, 35294, USA

    Daniel C. Bullard

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    Klaus Ley

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Bullard, D.C. (2007). P- and E-selectin. In: Ley, K. (eds) Adhesion Molecules: Function and Inhibition. Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-7975-9_3

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