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Inhibitors that target gp120-CD4 interactions

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Entry Inhibitors in HIV Therapy

Part of the book series: Milestones in Drug Therapy ((MDT))

Abstract

The treatment of HIV-1 is moving towards chronic management of the disease, e.g., by combining three-drug regimens to reduce the number of dosing units. However, four classes (nucleoside/nucleotide and non-nucleoside reverse transcriptase, protease, and fusion inhibitors) including 24 approved drugs are still inadequate and treatment failures continue to occur. Factors contributing to such failures include: the emergence of drug-resistant strains, suboptimal exposure, and poor adherence that is mainly attributable to side effects. Moreover, the transmission of drug-resistant viruses is expected to rise over time. For these reasons, there is a pressing need for new classes of antiretroviral agents that are effective against HIV-1 resistant or insensitive to current drugs and that have the potential for co-formulation in convenient dosing regimens.

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Author information

Authors and Affiliations

  1. Department of Virology Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, CT, 06492, USA

    Pin-fang Lin & Louis Alexander

  2. Department of Chemistry Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, CT, 06492, USA

    John Kadow

Authors
  1. Pin-fang Lin
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  2. John Kadow
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  3. Louis Alexander
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Editor information

Editors and Affiliations

  1. Monogram Biosciences, 345 Oyster Point Blvd., South San Francisco, CA, 94080, USA

    Jacqueline D. Reeves

  2. Department of Pathology and Laboratory Medicine, Emory Vaccine Center, Emory University, 954 Gatewood Rd, Suite 1024, Atlanta, GA, 30329, USA

    Cynthia A. Derdeyn

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© 2007 Birkhäuser Verlag/Switzerland

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Lin, Pf., Kadow, J., Alexander, L. (2007). Inhibitors that target gp120-CD4 interactions. In: Reeves, J.D., Derdeyn, C.A. (eds) Entry Inhibitors in HIV Therapy. Milestones in Drug Therapy. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-7783-0_4

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