Skip to main content

Murine collagen induced arthritis

  • Chapter
In Vivo Models of Inflammation

Part of the book series: Progress in Inflammation Research ((PIR))

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Trentham DE, Townes AS, Kang AH (1977) Autoimmunity to type II collagen: an experimental model of arthritis. J Exp Med 146: 857–868

    Article  PubMed  CAS  Google Scholar 

  2. Stuart JM, Townes AS, Kang AH (1982) Nature and specificity of immune responses to collagen in type II collagen-induced arthritis in mice. J Clin Invest 69: 673–683

    PubMed  CAS  Google Scholar 

  3. Holmdahl R, Malmstrom V, Vuorio E (1993) Autoimmune recognition of cartilage collagens. Ann Med 25: 251–264

    PubMed  CAS  Google Scholar 

  4. Glant TT, Mikecz K, Arzoumanian A, Poole AR (1987). Proteoglycan-induced arthritis in BALB/c mice. Clinical features and histopathology. Arthritis Rheum 30: 201–212

    PubMed  CAS  Google Scholar 

  5. Cremer MA, Ye XJ, Terato K, Owens SW, Seyer JM, Kang AH (1994) Type XI collagen-induced arthritis in the Lewis rat. Characterization of cellular and humoral immune responses to native types XI, V, and II collagen and constituent α-chains. J Immunol 153: 824–832

    PubMed  CAS  Google Scholar 

  6. Verheijden GFM, Rijnders AWM, Bos E, Coenen-de Roo CJJ, van Staveren CJ, Miltenburg AMM, Meijerink JH, Elewaut D, de Keyser F, Veys E, Boots AMH (1997) Human cartilage glycoprotein-39 as a candidate autoantigen in rheumatoid arthritis. Arthritis Rheum 40: 1115–1125

    PubMed  CAS  Google Scholar 

  7. Wooley PH, Luthra HS, Stuart JM, David CS (1981) Type II collagen-induced arthritis in mice: I. major histocompatibility complex (I-region) linkage and antibody correlates. J Exp Med 154: 688–700

    Article  PubMed  CAS  Google Scholar 

  8. Myers LK, Rosloniec EF, Cremer MA, Kang AH (1997) Collagen-induced arthritis, an animal model of autoimmunity. Life Sci 61: 1861–1878

    Article  PubMed  CAS  Google Scholar 

  9. Miller EJ, Rhodes RK (1982) Preparation and characterization of the different types of collagen. Methods Enzymol 82: 33–65

    PubMed  CAS  Google Scholar 

  10. Stuart J, Townes A, Kang A (1984) Collagen autoimmune arthritis. Annu Rev Immunol 2: 199–218

    Article  PubMed  CAS  Google Scholar 

  11. Holmdahl R, Klareskog L, Rubin K, Larsson E, Wigzell H (1985) T lymphocytes in collagen IL-induced arthritis in mice. Characterization of arthritogenic collagen II-specific T-cell lines and clones. Scand J Immunol 22: 295–306

    Article  PubMed  CAS  Google Scholar 

  12. Mauri C, Williams RO, Walmsley M, Feldmann M (1996) Relationship between Th/Th2 cytokine patterns and the arthritogenic response in collagen-induced arthritis. Eur J Immunol 26: 1511–1518

    PubMed  CAS  Google Scholar 

  13. Germann T, Szeliga J, Hess H, Störkel S, Podlaski F, Gately M, Schmitt E, Rüde E (1995) Administration of IL-12 in combination with type II collagen induces severe arthritis in DBA/1 mice. Proc Natl Acad Sci USA 92: 4823

    Article  PubMed  CAS  Google Scholar 

  14. Szeliga J, Hess H, Rüde E, Schmitt E, Germann T (1996) IL-12 promotes cellular but not humoral type II collagen-specific Th1-type responses in C57Bl/6 and B10.Q mice and fails to induce arthritis. Int Immunol 8: 1221–1227

    PubMed  CAS  Google Scholar 

  15. Killar LM, Dunn CJ (1989) Interleukin-1 potentiates the development of collagen-induced arthritis in mice. Clin Sci (Colch) 76: 535–538

    CAS  Google Scholar 

  16. Cooper WO, Fava RA, Gates CA, Cremer MA, Townes AS (1992) Acceleration of onset of collagen-induced arthritis by intra-articular injection of tumor necrosis factor or TGFß. Clin Exp Immunol 89: 244–250

    Article  PubMed  CAS  Google Scholar 

  17. Santambrogio L, Hochwald GM, Leu GH, Thorbecke GJ (1993) Antagonistic effects of endogenous and exogenous TGFß and TNFα on autoimmune diseases in mice. Immunopharmacol Immunotoxicol 15: 461–478

    PubMed  CAS  Google Scholar 

  18. Caccese RG, Zimmerman JL, Carlson RP (1992) Bacterial lipopolysaccharide potentiates type II collagen-induced arthritis in mice. Mediators Inflamm 1: 273–279

    CAS  PubMed  Google Scholar 

  19. Joosten LAB, Lubberts E, Helsen MMA, van den Berg WB (1997) Dual role of IL-12 in early and late stages of murine collagen type II arthritis. J Immunol 159: 4094–4102

    PubMed  CAS  Google Scholar 

  20. Joosten LAB, Helsen MMA, van den Berg WB (1994) Accelerated onset of collagen-induced arthritis by remote inflammation. Clin Exp Immunol 97: 204–211

    Article  PubMed  CAS  Google Scholar 

  21. Campbell IK, Hamilton JA, Wicks IP (2000) Collagen-induced arthritis in C57BL/6 (H-2b) mice: new insights into an important disease model of rheumatoid arthritis. Eur J Immunol 30: 1568–1575

    Article  PubMed  CAS  Google Scholar 

  22. Lawlor KE, Campbell IK, Metcalf D, O’Donnell K, van Nieuwenhuijze A, Roberts AW, Wicks IP (2004) Critical role for granulocyte colony-stimulating factor in inflammatory arthritis. Proc Natl Acad Sci USA 101: 11398–11403

    Article  PubMed  CAS  Google Scholar 

  23. Stuart JM, Dixon FJ (1983) Serum transfer of collagen-induced arthritis in mice. J Exp Med 158: 378–392

    Article  PubMed  CAS  Google Scholar 

  24. Terato K, Hasty KA, Reife RA, Cremer MA, Kang AH, Stuart JM (1992) Induction of arthritis with monoclonal antibodies to collagen. J Immunol 148: 2103–2108

    PubMed  CAS  Google Scholar 

  25. Schalkwijk J, van den Berg WB, Joosten LAB, van de Putte LBA (1987) Elastase secreted by activated polymorphonuclear leucocytes causes chondrocyte damage and matrix degradation in intact articular cartilage: escape from inactivation by alpha-1-proteinase inhibitor. Br J Exp Pathol 68: 81–88

    PubMed  CAS  Google Scholar 

  26. Van Lent PLEM, van den Bersselaar L, van de Putte LBA, van den Berg WB (1990) Immobilization aggravates cartilage damage during antigen-induced arthritis in mice. Attachment of polymorphonuclear leucocytes to articular cartilage. Am J Pathol 136:1407–1416

    PubMed  Google Scholar 

  27. Van Meurs JBJ, van Lent PLEM, Singer II, Bayne EK, van de Loo FAJ, van den Berg WB (1998) IL-1ra prevents expression of the metalloproteinase-generated neoepitope VDIPEN in antigen-induced arthritis. Arthritis Rheum 41: 647–656

    Article  PubMed  Google Scholar 

  28. Kakimoto K, Matsukawa A, Yoshinaga M, Nakamura H (1995) Suppressive effect of neutrophil elastase inhibitor on the development of collagen-induced arthritis. Cell Immunol 165: 26–32

    Article  PubMed  CAS  Google Scholar 

  29. Williams RO, Feldmann M, Maini RN (1992) Anti-tumor necrosis factor ameliorates joints disease in murine collagen-induced arthritis. Proc Natl Acad Sci USA 89:9784–9788

    Article  PubMed  CAS  Google Scholar 

  30. Joosten LAB, Helsen MMA, van de Loo FAJ, van den Berg WB (1996) Anticytokine treatment of established type II collagen-induced arthritis in DBA/1 mice: a comparative study using anti-TNFα, anti-IL-1α/ß, and IL-1Ra. Arthritis Rheum 39: 797–809

    PubMed  CAS  Google Scholar 

  31. Van den Berg WB, Joosten LAB, Helsen MMA, van de Loo AAJ (1994) Amelioration of established murine collagen-induced arthritis with anti-IL-1 treatment. Clin Exp Immunol 95: 237–243

    Article  PubMed  Google Scholar 

  32. Mori L, Iselin S, Delibero G, Lesslauer W (1996) Attenuation of collagen induced arthritis in 55kDa TNF receptor type 1 (TNFR1) IgG1 treated and TNFR1 deficient mice. J Immunol 157: 3178–3182

    PubMed  CAS  Google Scholar 

  33. Kuiper S, Joosten LAB, Bendele AM, Edwards CK III, Arntz OJ, Helsen MMA, van de Loo FAJ, van den Berg WB (1998) Different roles of TNFα and IL-1 in murine streptococcal cell wall arthritis. Cytokine 10: 690–702

    Article  PubMed  CAS  Google Scholar 

  34. Van Lent PLEM, Holthuysen AEM, van den Bersselaar LAM, van Rooijen N, Joosten LAB, van de Loo FAJ, van de Putte LBA, van den Berg WB (1996) Phagocytic lining cells determine local expression of inflammation in type II collagen-induced arthritis. Arthritis Rheum 39: 1545–1555

    PubMed  Google Scholar 

  35. Kasama T, Strieter RM, Lukacs NW, Lincoln PM, Burdick MD, Kunkel SL (1995) IL-10 expression and chemokine regulation during the evolution of murine type II collagen-induced arthritis. J Clin Invest 95: 2868–2876

    PubMed  CAS  Google Scholar 

  36. Joosten LAB, Lubberts E, Durez P, Helsen MMA, Jacobs MJM, Goldman M, van den Berg WB (1997) Role of IL-4 and IL-10 in murine collagen-induced arthritis. Arthritis Rheum 40: 249–259

    PubMed  CAS  Google Scholar 

  37. Lubberts E, Joosten LAB, Chabaud M, van Den Bersselaar L, Oppers B, Coenen-De Roo CJ, Richards CD, Miossec P, van Den Berg WB (2000) IL-4 gene therapy for collagen arthritis suppresses synovial IL-17 and osteoprotegerin ligand and prevents bone erosion. J Clin Invest 105: 1697–1710

    Article  PubMed  CAS  Google Scholar 

  38. McIntyre KW, Shuster DJ, Gillooly KM, Warrier RR, Connaughton SE, Hall LB, Arp LH, Gately MK, Magram J (1996) Reduced incidence and severity of collagen-induced arthritis in interleukin-12-deficient mice. Eur J Immunol 26: 2933–2938

    PubMed  CAS  Google Scholar 

  39. Leung BP, McInnes IB, Esfandiari E, Wei XQ, Liew FY (2000) Combined effects of IL-12 and IL-18 on the induction of collagen-induced arthritis. J Immunol 164: 6495–6502

    PubMed  CAS  Google Scholar 

  40. Shah MH, Hackshaw KV, Caligiuri MA (1998) A role for IL-15 in rheumatoid arthritis? Nat Med 4: 643

    Article  PubMed  CAS  Google Scholar 

  41. McInnes IB, Liew FY (1998) Interleukin 15: a proinflammatory role in rheumatoid arthritis synovitis. Immunol Today 19: 75–79

    Article  PubMed  CAS  Google Scholar 

  42. Ruchatz H, Leung BP, Wei XQ, McInnes IB, Liew FY (1998) Soluble IL-15 receptor alpha-chain administration prevents murine collagen-induced arthritis: a role for IL-15 in development of antigen-induced immunopathology. J Immunol 160: 5654–5660

    PubMed  CAS  Google Scholar 

  43. Ferrari-Lacraz S, Zanelli E, Neuberg M, Donskoy E, Kim YS, Zheng XX, Hancock WW, Maslinski W, Li XC, Strom TB, Moll T (2004) Targeting IL-15 receptor-bearing cells with an antagonist mutant IL-15/Fc protein prevents disease development and progression in murine collagen-induced arthritis. J Immunol 173: 5818–5826

    PubMed  CAS  Google Scholar 

  44. Fossiez F, Djossou O, Chomarat P, Flores-Romo L, Ait-Yahia S, Maat C, Pin JJ, Garrone P, Garcia E, Saeland S et al (1996) T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines. J Exp Med 183: 2593–2603

    Article  PubMed  CAS  Google Scholar 

  45. Kotake S, Udagawa N, Takahashi N, Matsuzaki K, Itoh K, Ishiyama S, Saito S, Inoue K, Kamatani N, Gillespie MT et al (1999) IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis. J Clin Invest 103:1345–1352

    PubMed  CAS  Google Scholar 

  46. Chabaud M, Durand JM, Buchs N, Fossiez F, Page G, Frappart L, Miossec P (1999) Human interleukin-17: A T cell-derived proinflammatory cytokine produced by the rheumatoid synovium. Arthritis Rheum 42: 963–970

    Article  PubMed  CAS  Google Scholar 

  47. Chabaud M, Lubberts E, Joosten L, van Den Berg W, Miossec P (2001) IL-17 derived from juxta-articular bone and synovium contributes to joint degradation in rheumatoid arthritis. Arthritis Res 3: 168–177

    Article  PubMed  CAS  Google Scholar 

  48. Lubberts E, Koenders MI, Oppers-Walgreen B, van den Bersselaar L, Coenen-de Roo CJ, Joosten LA, van den Berg WB (2004) Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen-induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion. Arthritis Rheum 50: 650–659

    Article  PubMed  CAS  Google Scholar 

  49. Lubberts E, van den Bersselaar L, Oppers-Walgreen B, Schwarzenberger P, Coenen-de Roo CJ, Kolls JK, Joosten LA, van den Berg WB (2003) IL-17 promotes bone erosion in murine collagen-induced arthritis through loss of the receptor activator of NF-kappa B ligand/osteoprotegerin balance. J Immunol 170: 2655–2662

    PubMed  CAS  Google Scholar 

  50. Hsu H, Lacey DL, Dunstan CR, Solovyev I, Colombero A, Timms E, Tan HL, Elliott G, Kelley MJ, Sarosi I et al (1999) Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand. Proc Natl Acad Sci USA 96: 3540–3545

    Article  PubMed  CAS  Google Scholar 

  51. Kong YY, Feige U, Sarosi I, Bolon B, Tafuri A, Morony S, Capparelli C, Li J, Elliott R, McCabe S et al (1999) Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand. Nature 402: 304–309

    Article  PubMed  CAS  Google Scholar 

  52. Romas E, Sims NA, Hards DK, Lindsay M, Quinn JW, Ryan PF, Dunstan CR, Martin TJ, Gillespie MT (2002) Osteoprotegerin reduces osteoclast numbers and prevents bone erosion in collagen-induced arthritis. Am J Pathol 161: 1419–1427

    PubMed  CAS  Google Scholar 

  53. Pettit AR, Ji H, von Stechow D, Muller R, Goldring SR, Choi Y, Benoist C, Gravallese EM (2001) TRANCE/RANKL knockout mice are protected from bone erosion in a serum transfer model of arthritis. Am J Pathol 159: 1689–1699

    PubMed  CAS  Google Scholar 

  54. Okamura H, Tsutsi H, Komatsu T, Yutsudo M, Hakura A, Tanimoto T, Torigoe K, Okura T, Nukada Y, Hattori K (1995) Cloning of a new cytokine that induces IFN-gamma production by T cells. Nature 378: 88–91

    Article  PubMed  CAS  Google Scholar 

  55. Dinarello CA, Novick D, Puren AJ, Fantuzzi G, Shapiro L, Muhl H, Yoon DY, Reznikov LL, Kim SH, Rubinstein M (1998) Overview of interleukin-18: more than an interferon-gamma inducing factor. J Leukoc Biol 63: 658–664

    PubMed  CAS  Google Scholar 

  56. Plater-Zyberk C, Joosten LAB, Helsen MM, Sattonnet-Roche P, Siegfried C, Alouani S, van De Loo FA, Graber P, Aloni S, Cirillo R et al (2001) Therapeutic effect of neutralizing endogenous IL-18 activity in the collagen-induced model of arthritis. J Clin Invest 108: 1825–1832

    Article  PubMed  CAS  Google Scholar 

  57. Wei XQ, Leung BP, Arthur HM, McInnes IB, Liew FY (2001) Reduced incidence and severity of collagen-induced arthritis in mice lacking IL-18. J Immunol 166: 517–521

    PubMed  CAS  Google Scholar 

  58. Novick D, Kim SH, Fantuzzi G, Reznikov LL, Dinarello CA, Rubinstein M (1999) Interleukin-18 binding protein: a novel modulator of the Th1 cytokine response. Immunity 10: 127–136

    Article  PubMed  CAS  Google Scholar 

  59. Smeets RL, van de Loo FA, Arntz OJ, Bennink MB, Joosten LA, van den Berg WB (2003) Adenoviral delivery of IL-18 binding protein C ameliorates collagen-induced arthritis in mice. Gene Ther 10: 1004–1011

    Article  PubMed  CAS  Google Scholar 

  60. Oppmann B, Lesley R, Blom B, Timans JC, Xu Y, Hunte B, Vega F, Yu N, Wang J, Singh K (2000) Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 13: 715–725

    Article  PubMed  CAS  Google Scholar 

  61. Murphy CA, Langrish CL, Chen Y, Blumenschein W, McClanahan T, Kastelein RA, Sedgwick JD, Cua DJ (2003) Divergent pro-and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation. J Exp Med 198: 1951–1957

    Article  PubMed  CAS  Google Scholar 

  62. Griffiths RJ, Smith MA, Roach ML, Stam EJ, Milici AJ, Scampoli DN, Eskra JD, Byrum RS, Koller BH, McNeish JD (1997) Collagen-induced arthritis is reduced in 5-lipoxygenase-activating CT: protein-deficient mice. J Exp Med 185: 1123–1129

    Article  PubMed  CAS  Google Scholar 

  63. Mansson B, Carey D, Alini M, Ionescu M, Rosenberg LC, Poole AR, Heinegard D, Saxne T (1995) Cartilage and bone metabolism in RA. Differences between rapid and slow progression of disease identified by serum markers of cartilage metabolism. J Clin Invest 95: 1071–1077

    PubMed  CAS  Google Scholar 

  64. Bakker AC, Joosten LAB, Arntz OJ, Helsen MMA, Bendele A, van de Loo FAJ, van den Berg WB (1997) Prevention of murine collagen-induced arthritis in the knee and ipsilateral paw by local expression of human IL-1Ra protein in the knee. Arthritis Rheum 40:893–900

    PubMed  CAS  Google Scholar 

  65. Myers LK, Seyer JM, Stuart JM, Kang AH (1997) Suppression of murine collagen-induced arthritis by nasal administration of collagen. Immunology 90: 161–164

    Article  PubMed  CAS  Google Scholar 

  66. Miossec P, van den Berg WB (1997). Th1/Th2 cytokine balance in arthritis. Arthritis Rheum 40: 2105–2115

    PubMed  CAS  Google Scholar 

  67. Van den Berg WB (1998) Animal models of arthritis: Applicability. In: P Maddison, D Isenberg, P Woo, D Glass (eds): Oxford Textbook of Arthritis. Oxford University Press, Oxford, 559–573

    Google Scholar 

  68. Van den Berg WB, van den Broek MF, van de Putte LBA, van Bruggen MCJ, van Lent PLEM (1991) Experimental arthritis: Importance of T cells and antigen mimicry in chronicity and treatment. In: Kresina TF (ed): Monoclonal Antibodies, Cytokines, and Arthritis. Dekker, New York, 237–252

    Google Scholar 

  69. Van den Berg WB (1998) Role of T cells in arthritis: Lessons from animal models. In: P Miossec, WB van den Berg WB, GS Firestein (eds): T Cells in Arthritis (PIR). Birkhäuser Verlag, Basel, 75–92

    Google Scholar 

  70. Van den Berg WB (2004) Animals models. In: St Clair EW, Pisetsky DS, Haynes BF (eds): Textbook Rheumatoid Arthritis. Lippincott Williams & Wilkins, Philadelphia, 254–267

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2006 Birkhäuser Verlag Basel/Switzerland

About this chapter

Cite this chapter

Joosten, L.A.B., van den Berg, W.B. (2006). Murine collagen induced arthritis. In: Stevenson, C.S., Marshall, L.A., Morgan, D.W. (eds) In Vivo Models of Inflammation. Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-7520-1_2

Download citation

  • DOI: https://doi.org/10.1007/978-3-7643-7520-1_2

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-7643-7519-5

  • Online ISBN: 978-3-7643-7520-1

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics