Summary
We investigated the short-term effects of an intrathecal bolus injection of baclofen on central pain due to stroke or spinal cord injury. Pain relief was obtained in 64% of the patients. The effects developed 1–2 hours after the injection and continued for 10–24 hours. Both spinal segmental and supraspinal mechanisms may be involved in the production of baclofen-analgesia.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Blumenkopf B (1991) The general aspects of neuropharmacology of dorsal horn function. Adv Pain Res Ther 151–176
Cutting DA, Jordan CC (1975) Alternative approach to analgesia: baclofen as a model compound. Br J Pharmac 54: 171–179
Gybels JM (1992) Indications for neurosurgical treatment of chronic pain. Acta Neurochir (Wien) 116: 171–175
Henry JL, Ben-Ari Y (1976) Action of the p-chlorophenyl deriva-tive of GABA, Lioresal, on nociceptive and non-nociceptive units in the spinal cord of the cat. Brain Res 117: 540–544
Herman RM, D’Luzansky SD, Ippolito R (1992) Intrathecal baclofen suppresses central pain in patients with spinal lesions. Clin J Pain 8: 338–345
Levy RA, Proudfit HK (1977) The analgesic action of baclofen [ß-(4-chlorophenyl)-y-aminobutylic acid. J Pharmac Exp Ther 202: 437–445
Magora F, Magora A, Vatine J J, Shochina M (1992) Clinical and electrophysiological effects of subarachnoid baclofen in low back pain. In: Hyodo M, Oyama T, Swerdlow (eds) The pain clinic IV, VSP Utrecht, pp 75–80
Minami T, Uda R, Horiguchi S, Ito S, Hyodo M, Hayaishi O (1992) Effects of Clonidine and baclofen on prostaglandin F2a induced allodynia in conscious mice. Pain Res 7: 129–134
Price GW, Wilkin GP, Turnbull MJ, Bowery NG (1984) Are baclofen sensitive GABAb receptors present on the primary afferent terminals of the spinal cord? Nature 307: 71–73
Proudfit HK, Levy RA (1978) Delimitation of neuronal substrates necessary for the analgesic action of baclofen and morphine. Eur J Pharmac 47: 159–166
Stiller CO, O’Connors W, Linderoth B, Hammarstrom G, Brodin E (1992) PAG-microdialysis in the awake, freely moving rat during spinal cord stimulation: Release of GABA. Acta Neurochir (Wien) 117: 87 (abstract)
Wilson PR, Yaksh TL (1978) Baclofen is antinociceptive in the spinal intrathecal space of animals. Euro J Pharmac 51: 323–330
Yaksh TL, Reddy SVR (1987) Studies in the primate on the analgetic effects associated with intrathecal actions of opiates, α-adrenergic agonists and baclofen. Anesthesiology 54: 451–467
Yaksh TL, Yamamoto T (1991) Studies on the pharmacology of spinal systems underlying anomalous pain states. Adv Pain Res Ther. 197–207
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1995 Springer-Verlag
About this paper
Cite this paper
Taira, T. et al. (1995). A New Approach to the Control of Central Deafferentation Pain—Spinal Intrathecal Baclofen. In: Meyerson, B.A., Ostertag, C. (eds) Advances in Stereotactic and Functional Neurosurgery 11. Acta Neurochirurgica Supplementum, vol 64. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9419-5_30
Download citation
DOI: https://doi.org/10.1007/978-3-7091-9419-5_30
Publisher Name: Springer, Vienna
Print ISBN: 978-3-7091-9421-8
Online ISBN: 978-3-7091-9419-5
eBook Packages: Springer Book Archive