Skip to main content

Radiotherapie maligner gastrointestinaler Tumoren

  • Conference paper
Maligne gastrointestinale Tumoren

Part of the book series: Angewandte Onkologie ((AONKOLOGIE))

  • 24 Accesses

Zusammenfassung

Das Ösophaguskarzinom ist durch das Fehlen von Frühsymptomen eine fatale Erkrankung und stellt somit eine enorme Herausforderung an die interdisziplinäre Onkologie dar. Da beim Ösophaguskarzinom in 53%–70% das Risiko einer Lymphknotenbeteiligung und einer generalisierten Metastasierung bei Diagnosestellung besteht [1, 2], kann nur ein stark Selektioniertes Krankengut einer Operation zugeführt werden. Von einer chirurgischen Resektion profitieren nur Patienten, bei denen eine komplette Tumorentfernung (RO-Resektion) erreicht werden kann [3]. Eine große chirurgische Untersuchungsserie an unselektionier- tem Krankengut zeigte, daß das 2-Jahres-Überleben bei nur operierten oder nur bestrahlten Patienten ident ist und etwa 5% beträgt [4–6].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 44.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 59.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Gunnlaugsson GH, Wychulis AR, Roland C, et al (1970) Analysis of the records of 1.657 patients with carcinoma of the esophagus and cardia of the stomach. Surg Gynecol Obstet 130: 997

    PubMed  CAS  Google Scholar 

  2. King RM, Pairolero PC, Trastek VF, etal (1987) Ivor Lewis esophagogastrectomy for car¬cinoma of the esophagus: early and late functional results. Ann Thorac Surg 44: 119

    Article  PubMed  CAS  Google Scholar 

  3. Fink U, Stein HJ, Bochtler H, et al (1994) Neoadjuvant therapy for squamous cell esophageal carcinoma. Ann Oncol 5 [Suppl] 3: 17

    Google Scholar 

  4. Earlam R, Cunha-Melo JR (1980) Oesophageal squamous cell carcinoma. I. A critical review of surgery. Br J Surg 67: 381

    Google Scholar 

  5. Earlam R, Cunha-Melo JR (1980) Oesophageal squamous cell carcinoma. II. A critical review of radiotherapy. Br J Surg 67: 457

    Google Scholar 

  6. Muller JM, Erasmi H, Stelzner M, et al (1990) Surgical therapy of oesophageal carcinoma. Br J Surg 77: 857

    Article  Google Scholar 

  7. Kasai M, Mori S, Watanabe T (1978) Follow-up results after resection of thoracic esophageal carcinoma. World J Surg 2: 543

    Article  PubMed  CAS  Google Scholar 

  8. Guernsey JM, Knudsen DF (1970) Abdominal exploration in the evaluation of patients with carcinoma of the thoracic esophagus. J Thorac Cardiovasc Surg 59: 62

    PubMed  CAS  Google Scholar 

  9. Doggett RLS, Guernsey JM, Bagshaw MA (1970) Combined radiation and surgical treatment of carcinoma of the thoracic esophagus. Front Radiat Ther Oncol 5: 147

    Google Scholar 

  10. Fischer SA, Brady LW (1986) Carcinoma of the esophagus. In: Perez CA, Brady LW (eds) Principles and practice of radiation oncology. Lippincott, Philadelphia, p 700

    Google Scholar 

  11. Akakura I, Nakamura Y, Kakegaw T, et al (1970) Surgery of carcinoma of the esophagus with preoperative radiation. Chest 57: 47

    Article  PubMed  CAS  Google Scholar 

  12. Sugimachi K, Matsufuji H, Kai H, et al (1986) Preoperative irradiation for carcinoma of the esophagus. Surg Gynecol Obstet 162: 174

    PubMed  CAS  Google Scholar 

  13. Marks RD, Scruggs HJ, Wallace KM (1976) Preoperative radiation therapy for carcinoma of the esophagus. Cancer 38: 84

    Article  PubMed  Google Scholar 

  14. Gignoux M, Buyse M, Segol P, et al (1982) Radiotherapie preoperatoire du cancer de I’esophage: résultat préliminaires d’unessai randomise de l’EORTC. Acta Chîr Belg 82: 373

    PubMed  CAS  Google Scholar 

  15. Mei W, Xian-Zhi G, Weibo Y, et al (1989) Randomized clinical trial on the combination of preoperative irradiation and surgery in the treatment of esophageal carcinoma: report on 206 patients. Int J Radiat Oncol Biol Phys 16: 325

    Article  Google Scholar 

  16. Launois B, DeLarue D, Campion JP, et al (1980) Preoperative radiotherapy for carcinoma of the esophagus. Surg Gynecol Obstet 153: 690

    Google Scholar 

  17. Guo-Jun H, Xiang-Zhi G (1987) Experience with combined preoperative irradiation and surgery for squamous cell carcinoma of the esophagus. In: Wagner G, Zhang Y-H (eds) Cancer of the liver, esophagus, and nasopharynx. Springer, Berlin Heidelberg New York Tokyo

    Google Scholar 

  18. Wang M, Gu XZ, Yin WB, et al (1989) Randomized clinical trial on the combination of preoperative irradiation and surgery in the treatment of esophageal carcinoma: report on 206 patients. Int J Radiat Oncol Biol Phys 16: 325

    Article  PubMed  CAS  Google Scholar 

  19. Franklin R, Steiger Z, Vaishampayan G, et al (1983) Combined modality therapy for esophageal squamous cell carcinoma. Cancer 51: 1062

    Article  PubMed  CAS  Google Scholar 

  20. Seydel HG, Leichman L, Byhardt R, et al (1988) Preoperative radiation and chemo¬therapy for localized squamous cell carcinoma of the esophagus: a RTOG study. Int J Radiat Oncol Biol Phys 14: 33

    Article  PubMed  CAS  Google Scholar 

  21. Poplin E, Fleming T, Leichman L, et al (1987) Combined therapies for squamous cell carcinoma of the esophagus: a Southwest Oncology Group study (SWOG-8037). J Clin Oncol 5: 622

    PubMed  CAS  Google Scholar 

  22. Leichman L, Steiger Z, Seydel HG, et al (1984) Combined preoperative chemotherapy and radiation therapy for cancer of the esophagus: the Wayne State University, Southwest Oncology Group and Radiation Therapy Oncology Group experience. Semin Oncol 11: 178

    PubMed  CAS  Google Scholar 

  23. Leichman L, Herskovic A, Leichman CG, et al (1987) Non-operative therapy for squamous-cell cancer of the esophagus. J Clin Oncol 5: 365

    PubMed  CAS  Google Scholar 

  24. Elkon D, Lee M-S, Hendrickson FR (1978) Carcinoma of the esophagus: sites of recurrence and palliative benefits after definitive radiotherapy. Int J Radiat Oncol Biol Phys 4: 615

    Article  PubMed  CAS  Google Scholar 

  25. Wara WM, Mauch PM, Thomas AN, et al (1976) Palliation for carcinoma of the esophagus. Radiology 121: 717

    PubMed  CAS  Google Scholar 

  26. Yin W-B, Zhang L, Miao Y, et al (1983) The results of high-energy electron therapy in carcinoma of the esophagus compared with telecobalt therapy. Clin Radiol 34: 113

    Article  PubMed  CAS  Google Scholar 

  27. Keane TJ, Harwood AR, Elhakim T, et al (1985) Radical radiation therapy with 5-fluorouracil infusion and mitomycin C for esophageal squamous carcinoma. Radiother Oncol 4: 205

    Article  PubMed  CAS  Google Scholar 

  28. Lokich JJ, Shea M, Chaffey J (1987) Sequential infusional 5-fluorouracil followed by concomitant radiation for tumors of the esophagus and gastroesophageal junction. Cancer 60: 275

    Article  PubMed  CAS  Google Scholar 

  29. Coia LR, Engstrom PF, Paul AR (1987) Non-surgical management of esophageal cancer: report of a study of combined radiotherapy and chemotherapy, j Clin Oncol 5: 1783

    CAS  Google Scholar 

  30. Coia LR, Paul AR, Engstrom PF (1988) Combined radiation and chemotherapy as primary management of adenocarcinoma of the esophagus and gastroesophageal junction. Cancer 61: 643

    Article  PubMed  CAS  Google Scholar 

  31. Sischy B, Ryan L, Haller D, et al (1990) Interim report of EST 1282 phase III protocol for the evaluation of combined modalities in the treatment of patients with carcinoma of the esophagus, stage 1 & II. Proc ASCO 9: 105 (abstr # 407)

    Google Scholar 

  32. Herskovic A, Martz K, Al-Sarraf M, et al (1992) Combined chemotherapy and radiotherapy compared with radiotherapy alone in patients with cancer of the esophagus. N Engl J Med 326: 1593

    Article  PubMed  CAS  Google Scholar 

  33. Kumar MU, Swamy K, Supe SS, et al (1993) Influence of intraluminal brachytherapy dose on complications in the treatment of esophageal cancer. Int J Radiat Oncol Biol Phys 27: 1069

    Article  PubMed  CAS  Google Scholar 

  34. Pakisch B, Jüttner-Smolle FG, Kohek P, et al (1990) Iridium-192 high-dose-rate intracavitary brachytherapy with and without external-beam irradation in unresectable oesophageal cancer. Reg Cancer Treat 3: 202

    Google Scholar 

  35. Gschossmann JM, Bonner JA, Foote RL, el al (1993) Malignant tracheoesophageal fistula in patients with esophageal cancer. Cancer 72: 1513

    Article  PubMed  CAS  Google Scholar 

  36. Howson CP, Hlyama T, Wynder EL (1986) The decline in gastric cancer: epidemiology of an unplanned triumph. Epidemiol Rev 8: 1

    PubMed  CAS  Google Scholar 

  37. Coggon D, Barker DJP, Cole RB, et al (1989) Stomach cancer and food storage. J Natl Cancer Inst 81: 1178

    Article  PubMed  CAS  Google Scholar 

  38. Dockerty MB (1964) Pathologic aspects of primary malignant neoplasms of the stomach. In: Re Mine WH, Priestley JT, Berkson J (eds) Cancer of the stomach. Saunders, Philadelphia, p 173

    Google Scholar 

  39. Gunderson LL, Sosin H (1982) Adenocarcinoma of the stomach: areas of failure in a reoperation series (second or symptomatic looks): clinico-pathologic correlation and implications for adjuvant therapy. Int J Radiat Oncol Biol Phys 8: 1

    PubMed  CAS  Google Scholar 

  40. Kennedy BJ, TNM (1970) Classification for stomach cancer. Cancer 26: 971

    Article  PubMed  CAS  Google Scholar 

  41. Ballon S, Berman M, Lagasse L, et al (1981) Survival after extraperitoneal pelvic and paraaortic lymphadenectomy and radiation therapy in cervical carcinoma. Obstet Gynecol 57: 90

    PubMed  CAS  Google Scholar 

  42. Emami B, Watring W, Tak W, et al (1980) Para aortic lymph node radiation in advanced cervical cancer. Int J Radiat Oncol Biol Phys 6: 1237

    Article  PubMed  CAS  Google Scholar 

  43. McNeer G, Vandenberg H, Donn FY, et al (1957) A critical evaluation of subtotal gastrectomy for the cure of cancer of the stomach. Ann Surg 134: 2

    Article  Google Scholar 

  44. Bitran JD, Desser RK, Kozioff MF, et al (1979) Treatment of metastatic pancreatic and gastric adenocarcinomas with 5-fluorouracil, adriamycin, and mitomycin C ( FAM ). Cancer Treat Rep 63: 2049

    PubMed  CAS  Google Scholar 

  45. Comis RL, Carter SK (1974) Integration of chemotherapy into combined-modality treatment of solid tumors. 111. Gastric cancer. Cancer Treat Rev 1: 221

    Article  Google Scholar 

  46. Moertel CG, Childs DS, O’Fallon JR, et al (1984) Combined 5-fluorouracil and radiation therapy as a surgical adjuvant for poor prognosis in gastric carcinoma. J Clin Oncol 2: 1249

    PubMed  CAS  Google Scholar 

  47. Hallissey MT, Dunn JA, Ward LC, et al (1994) The second British Stomach Cancer Group trial of adjuvant radiotherapy or chemotherapy in resectable gastric cancer: five-year follow-up. Lancet 343: 1309

    Article  PubMed  CAS  Google Scholar 

  48. Stoliarov VI, Volkov ON, Kanaev SV, et al (1984) Comparative evaluation of surgical and combined treatment of cancer of the proximal region of the stomach. Vopr Onkol 30: 31

    PubMed  CAS  Google Scholar 

  49. Asakawa H, Takeda T (1973) High energy x-ray therapy of gastric carcinoma. J Jpn Soc Cancer Ther 8: 362

    CAS  Google Scholar 

  50. Haas CD, Mansfield CM, Leichman LP, et al (1983) Combined non-simultaneous radiation therapy and chemotherapy with 5-FU, doxorubicin and mitomycin for residual localized gastric adenocarcinoma: a Southwest Oncology Group pilot study. Cancer Treat Rep 67: 421

    PubMed  CAS  Google Scholar 

  51. Wieland C, Hymmen U (1972) Megavoltage therapy for malignant gastric tumors. Strahlentherapie 40: 20

    Google Scholar 

  52. Robinson E, Cohen Y (1977) The combination of surgery, radiotherapy and chemo-therapy in the treatment of gastric cancer. Recent Results Cancer Res 32: 177

    Google Scholar 

  53. Moertel CG, Childs DS Jr, Reitemeier RJ, et al (1969) Combined 5-fluorouracil and supervoltage radiation therapy of locally unresectable gastrointestinal cancer. Lancet ii: 865

    Article  Google Scholar 

  54. Takahashi M, Abe M (1986) Intra-operative radiotherapy for carcinoma of the stomach. Eur J Surg Oncol 12: 247

    PubMed  CAS  Google Scholar 

  55. Sindelar WF, Kinsella TJ, Tepper JE, et al (1993) Randomized trial of intraoperative radiotherapy in carcinoma of the stomach. Am J Surg 165: 178

    Article  PubMed  CAS  Google Scholar 

  56. Calvo FA, Henriquez I, Santos M, et al (1989) Intraoperative and external beam radiotherapy in advanced resectable gastric cancer: technical description and preliminary results. Int J Radiat Oncol Biol Phys 1 7: 183

    Google Scholar 

  57. Duttenhaver JR, Hoskins RB, Gunderson LL, et al (1986) Adjuvant postoperative radiation therapy in the management of adenocarcinoma of the colon. Cancer 57: 955

    Article  PubMed  CAS  Google Scholar 

  58. Willett CG, Tepper JE, Skates SJ, et al (1987) Adjuvant postoperative radiation therapy for colonic carcinoma. Ann Surg 206: 694

    Article  PubMed  CAS  Google Scholar 

  59. Loeffler RK (1984) Postoperative radiation therapy for Duke’s C adenocarcinoma of the cecum using two fractions per day. Int J Radiat Oncol Biol Phys 10: 1881

    Article  PubMed  CAS  Google Scholar 

  60. Shehate WM, Meyer RL, Krause RJ, et al (1984) Postoperative adjuvant irradiation and 5-fluorouracil for adenocarcinoma of the cecum. Cancer 54: 2850

    Article  Google Scholar 

  61. Wang CS, Harwood AR, Cummings BJ, et al (1984) Total abdominal irradiation for cancer of colon. Radiother Oncol 2: 209

    Article  Google Scholar 

  62. Brenner HJ, Bibe C, Caltchik S (1983) Adjuvant therapy for Duke’s C adenocarcinoma of colon, int J Radiat Oncol Biol Phys 9: 1789

    CAS  Google Scholar 

  63. Gunderson LL, Martin JK, Beart RW, et al (1988) Intraoperative and external beam irradiation for locally advanced colorectal cancer. Ann Surg 207: 52

    Article  PubMed  CAS  Google Scholar 

  64. Abuchaibe O, Calvo FA, Azinovic I, et al (1993) Intraoperative radiotherapy in locally advanced recurrent colorectal cancer. Int J Radiat Oncol Biol Phys 26: 859

    Article  PubMed  CAS  Google Scholar 

  65. Gunderson L, Sosin H (1978) Areas of failure found at reoperation following curative surgery for adenocarcinoma of the rectum: clinicopathologic correlation and implication for adjuvant therapy. Cancer 34: 1278

    Article  Google Scholar 

  66. Moosa AR, Ree PC, Marks JE, et al (1975) Factory influencing local recurrence after abdominoperineal resection for cancer of the rectum and rectosigmoid. Br J Surg 62: 727

    Article  Google Scholar 

  67. Konsensus-Konferenz des National Institute of Health (NIH) (1990) Bethesda, MD

    Google Scholar 

  68. Brizel HE, Tepperman BS (1984) Postoperative adjuvant irradiation for adenocarci-noma of the rectum and sigmoid. Am J Clin Oncol 7: 679

    Article  PubMed  CAS  Google Scholar 

  69. Ghossein NA, Samala EC, Alpert S, et al (1981) Elective postoperative radiotherapy after incomplete resection of the colorectal cancer. Dis Colon Rectum 24: 252

    Article  PubMed  CAS  Google Scholar 

  70. Hoskins RB, Gunderson LL, Doseretz DE, et al (1985) Adjuvant postoperative radiotherapy in carcinoma of the rectum and rectosigmoid. Cancer 55: 61

    Article  PubMed  CAS  Google Scholar 

  71. Schild SE, Martenson JA Jr, Gunderson LL, et al (1989) Postoperative adjuvant therapy of rectal cancer: an analysis of disease control, survival, and prognostic factors. Int J Radiat Oncol Biol Phys 17: 55

    Article  PubMed  CAS  Google Scholar 

  72. Vigliotti A, Richt TA, Romsdohl MM, et al (1987) Postoperative adjuvant radiothera-py for adenocarcinoma of the rectum and rectosigmoid. Int J Radiat Oncol Biol Phys 13: 999

    Article  PubMed  CAS  Google Scholar 

  73. Zucali R, Gardani G, Lattuada A (1987) Adjuvant irradiation after radical surgery of cancer of the rectum and rectosigmoid. Radiother Oncol 8: 19

    Article  PubMed  CAS  Google Scholar 

  74. Gastrointestinal Tumor Study Group (1985) Prolongation of the disease-free interval in surgically treated rectal carcinoma. N Engl J Med 312: 1465

    Google Scholar 

  75. Gastrointestinal Tumor Study Group (1986) Survival after postoperative combination treatment of rectal cancer (letter). N Engl J Med 315: 1294

    Google Scholar 

  76. Gunderson LL, Collins R, Earle JD, et al (1986) Adjuvant treatment of rectal cancer: randomized prospective study of irradiation + chemotherapy: a NCCTG, Mayo Clinic study. Int J Radiat Oncol Biol Phys 5: 82 (abstr)

    Google Scholar 

  77. Krook J, Moertel CG, Wieand H, et al (1986) Radiation versus sequential chemo-therapy-radiation-chemotherapy. Proc ASCO 5: 82 (abstr #318)

    Google Scholar 

  78. O’Connel MJ (1986) Proc ASCO 5 (abstr)

    Google Scholar 

  79. Balslev IB, Pedersen M, Teglbjaerg PS, et a1 (1986) Postoperative radiotherapy In Duke’s B and C carcinoma of the rectum and rectosigmoid: a randomized multi-center study. Cancer 58: 22

    Article  PubMed  CAS  Google Scholar 

  80. Weaver D, Lindblad AS (1990) Radiation therapy and 5-fluorouraci (5-FU) with or without Me CCNU for the treatment of patients with surgically adjuvant adenocarcinoma of the rectum. Proc ASCO 9: 106 (abstr # 409)

    Google Scholar 

  81. Fisher B, Wolmark N, Rockette H, et al (1988) Postoperative adjuvant chemotherapy or radiation therapy for rectal cancer: result from NSABP protocol R-01. J Natl Cancer Inst 80: 21

    Article  PubMed  CAS  Google Scholar 

  82. Higgins GA Jr, Conn JH, Jordan PH Jr, et al (1975) Preoperative radiotherapy for colorectal cancer. Ann Surg 181: 624

    Article  PubMed  Google Scholar 

  83. Rider WD, Palmer JA, Mahoney LJ, et al (1977) Preoperative irradiation in operable cancer of the rectum: report of the Toronto trial. Can J Surg 20: 335

    PubMed  CAS  Google Scholar 

  84. Second Report of a MRC Working Party (1984) The evaluation of low dose pre-operative x-ray therapy in the management of operable rectal cancer: results of a randomly controlled trial. Br J Surg 71: 21

    Article  Google Scholar 

  85. Stockholm Rectal Cancer Study Group (1987) Short term preoperative radiotherapy for adenocarcinoma of the rectum: an interim analysis of randomized multicenter trial. Am J Clin Oncol 10: 369

    Google Scholar 

  86. Boulis-Wassif S, Langenhorst BL, Hop WCJ (1979) The contribution of preoperative radiotherapy in the management of borderline operability rectal cancer. In: Jones SE, Salmon SE (eds) Adjuvant therapy of cancer II. Grune & Stratton, New York, p 613

    Google Scholar 

  87. Reis Neto JA, Quilici FA, Reis JA Jr (1989) A comparison of non-operative vs preoperative radiotherapy in rectal carcinoma: a 10-year randomized trial. Dis Colon Rectum 32: 702

    Article  CAS  Google Scholar 

  88. Allee PE, Gunderson LL, Munzenrider JE (1981) Postoperative radiation therapy for residual colorectal carcinoma. IntJ Radiat Oncol Biol Phys 7: 1208 (abstr)

    Google Scholar 

  89. Pahlmann L, Glimelius B (1990) Pre- or postoperative radiotherapy in rectal and rectosigmoid carcinoma: report from a randomized multicenter trial. Ann Surg 211: 187

    Article  Google Scholar 

  90. Willett CG, Shellito PC, Tepper JE, et al (1991) Intraoperative electron beam radiation therapy for primary locally advanced rectal and rectosigmoid carcinoma. J Clin Oncol 9: 843

    PubMed  CAS  Google Scholar 

  91. Dosoretz DE, Gunderson LL, Hedberg S, et al (1983) Preoperative irradiation for unresectable rectal and rectosigmoid carcinomas. Cancer 52: 814

    Article  PubMed  CAS  Google Scholar 

  92. Emami B, Pilepich M, Willet C, et al (1982) Effect of preoperative irradiation on resectability of colorectal carcinomas. IntJ Radiat Oncol Biol Phys 8: 1295

    Article  CAS  Google Scholar 

  93. Gunderson LL, Cohen AC, Dosoretz DD, et al (1983) Residual, unresectable or recurrent colorectal cancer: external beam irradiation and intraoperative electron beam boost- resection. Int J Radiat Oncol Biol Phys 9: 1597

    PubMed  CAS  Google Scholar 

  94. Schild CE, Martenson JA Jr, Gunderson LL, et al (1989) Long-term survival and patterns of failure after postoperative radiation therapy for subtotally resected rectal adenocarcinoma. IntJ Radiat Oncol Biol Phys 16: 459

    Article  CAS  Google Scholar 

  95. Hildebrandt U, Feifel G (1985) Preoperative staging of rectal cancer by intrarectal ultrasound. Dis Colon Rectum 28: 42

    Article  PubMed  CAS  Google Scholar 

  96. Wang KY, Kimmey MB, Nyberg DA, et al (1987) Colorectal neoplasms: accuracy of US in demonstrating the depth of invasion. Radiology 165: 827

    PubMed  CAS  Google Scholar 

  97. Lavery IC, Jones IT, Weakly FL, et al (1987) Definitive management of rectal cancer by contact (endocavitary) irradiation. Dis Colon Rectum 30: 835

    Article  PubMed  CAS  Google Scholar 

  98. Papillon J (1982) Rectal and anal cancers: conservative treatment by irradiation — an alternative to radical surgery. Springer, Berlin Heidelberg New York

    Google Scholar 

  99. Sischy B, Hinson EJ, Wilkinson DR (1988) Definitive radiation therapy for selected cancers of the rectum. Br J Surg 75: 901

    Article  PubMed  CAS  Google Scholar 

  100. Hager TH, Gall FP, Hermaneck P (1983) Local excision of cancer of the rectum. Dis Colon Rectum 26: 149

    Article  PubMed  CAS  Google Scholar 

  101. Schratter-Sehn A, Kärcher KH (1990) Therapie-Monitoring und Nachsorge be-strahlter anorektaler Karzinome mittels Transrektalsonographie. Strahlenther Onkol 166: 659

    PubMed  CAS  Google Scholar 

  102. Schratter-Sehn AU, Miholic J, Kärcher KH, et al (1991) Wertigkeit der Transrektalsonographie in der Erfassung radiogener Rektumveränderungen. Strahlenther Onkol 167: 287

    PubMed  CAS  Google Scholar 

  103. Frost DB, Richards PC, Montague ED, et al (1984) Epidermoid cancer of the anorectum. Cancer 53: 1285

    Article  PubMed  CAS  Google Scholar 

  104. Papillon J, Mayer M, Montbarbon JF, et al (1983) A new approach to the management of epidermoid carcinoma of the anal canal. Cancer 51: 1830

    Article  PubMed  CAS  Google Scholar 

  105. Boman BM, Moertel CG, O’Connel MJ, et al (1984) Carcinoma of the anal canal: a clinical and pathological study of 188 cases. Cancer 54: 114

    Article  PubMed  CAS  Google Scholar 

  106. Hughes LL, Rich TA, Delclos L, et al (1989) Radiotherapy for anal cancer: experi¬ence from 1979–1987. Int J Radiat Oncol Biol Phys 17: 1153

    Article  PubMed  CAS  Google Scholar 

  107. Cummings B, Keane T, Thomas G, et al (1984) Results and toxicity of the treatment of anal carcinoma by radiation therapy or radiation therapy and chemotherapy. Cancer 54: 2062

    Article  PubMed  CAS  Google Scholar 

  108. Dogget SW, Green JP, Cantril ST (1988) Efficacy of radiation therapy alone for limited squamous cell carcinoma of the anal canal. Int J Radiat Oncol Biol Phys 15: 1069

    Article  Google Scholar 

  109. Cantril ST, Green JP, Schall GL, et al (1983) Primary radiation therapy in the treatment of anal carcinoma. Int J Radiat Oncol Biol Phys 9: 1271

    Article  PubMed  CAS  Google Scholar 

  110. Nigro ND, Vaitkevicius VK, BurokerT, etal (1981) Combined therapy for cancer of the anal canal. Dis Colon Rect 24: 73

    CAS  Google Scholar 

  111. Sischy B (1985) The use of radiation therapy combined with chemotherapy in the management of squamous cell carcinoma of the anus and marginally resectable adenocarcinoma of the rectum. Int J Radiat Oncol Biol Phys 11: 1587

    Article  PubMed  CAS  Google Scholar 

  112. Sischy B, Dogget RLS, Krall JM, et al (1989) Definitive irradiation and chemo-therapy for radiosensitization in management of anal carcinoma. Interim report on Radiation Therapy Oncology Group study No. 8314. J Natl Cancer Inst 81: 850

    Article  PubMed  CAS  Google Scholar 

  113. Warren KW, Braasch JW, Thum CW, et al (1968) Carcinoma of the pancreas. Surg Clin North Am 48: 601

    PubMed  CAS  Google Scholar 

  114. Rosenberg JM, Welch JP, Macaulay WP (1985) Cancer of the head of the pancreas: an institutional review with emphasis on surgical therapy. J Surg Oncol 28: 217

    Article  PubMed  CAS  Google Scholar 

  115. Dunn E (1987) The impact of technology and improved perioperative management upon survival from carcinoma of the pancreas. Surg Gynecol Obstet 164: 237

    PubMed  CAS  Google Scholar 

  116. Brooks JR, Culebras JM (1976) Cancer of the pancreas: palliative operation, Whipple procedure or total pancreatectomy? Am J Surg 131: 516

    Article  PubMed  CAS  Google Scholar 

  117. Tepper J, Nardi G, Suit H (1976) Carcinoma of the pancreas: review of MGH experience from 1963 to 1973 — analysis of surgical failure and implications for radiation therapy. Cancer 37: 1519

    Article  PubMed  CAS  Google Scholar 

  118. Griffin J, Smalley SR, Jewell W, et al (1990) Patterns of failure following curative resection of pancreatic carcinoma. Cancer 66: 56

    Article  PubMed  CAS  Google Scholar 

  119. Moertel CG, Frytak S, Hahn RG, et al (1981) Therapy of locally unresectable pancreatic carcinoma: a randomized comparison of high dose (6000 rads) radiation alone, moderate dose radiation (4000 rads + 5-fluorouraciI) and high dose radiation + 5-fluorouraciI. Cancer 48: 1 705

    Google Scholar 

  120. Gastrointestinal Tumor Study Group (1988) Treatment of locally unresectable carcinoma of the pancreas: comparison of combined-modality therapy (chemotherapy plus radiotherapy) to chemotherapy. J Natl Cancer Inst 80: 751

    Google Scholar 

  121. Appelqvist P, Viren M, Minkkinen J, et al (1983) Operative finding, treatment and prognosis of carcinoma of the pancreas: an analysis of 267 cases. J Surg Oncol 23: 143

    Article  PubMed  CAS  Google Scholar 

  122. Manabe T, Baba N, Nonaka A, et al (1988) Combined treatment using radiotherapy for carcinoma of the pancreas involving the adjacent vessels. Int J Surg 73: 153

    CAS  Google Scholar 

  123. Hiraoka T, Watanabe E, Mochinaga M, et al (1984) Intraoperative irradiation combined with radical resection for cancer of the head of the pancreas. World J Surg 8: 766

    Article  PubMed  CAS  Google Scholar 

  124. Gastrointestinal Tumor Study Group (1987) Further evidence of effective adjuvant combined radiation and chemotherapy following curative resection of pancreatic cancer. Cancer 59: 2006

    Google Scholar 

  125. Kopelson G (1983) Curative surgery for adenocarcinoma of the pancreas/ampulla of Vater: the role of adjuvant pre- or postoperative radiation therapy. Int J Radiat Oncol Biol Phys 9: 991

    Google Scholar 

  126. Weese JL (1989) Enhanced resectability of pancreatic and periampullary cancer after neoadjuvant chemoradiotherapy. Proc SACAAPACA (abstr)

    Google Scholar 

  127. Condie JD, Nagpal S, Peebles SA (1989) Surgical treatment for ductal adenocarcinoma of the pancreas. Surg Gynecol Obstet 168: 437

    PubMed  Google Scholar 

  128. Whittington R, Dobelbower RR, Mohiuddin M, et al (1981) Radiotherapy of unresectable pancreatic carcinoma: a six year experience with 104 patients. Int J Radiat Oncol Biol Phys 7: 1639

    Article  PubMed  CAS  Google Scholar 

  129. Nishimura A, Nakano M, Otsu H, et al (1984) Intraoperative radiotherapy for advanced carcinoma of the pancreas. Cancer 54: 2375

    Article  PubMed  CAS  Google Scholar 

  130. Sindelar WF (1988) Intraoperative radiotherapy in carcinomas of the stomach and pancreas. Cancer Res 110: 226

    CAS  Google Scholar 

  131. Shipley WU, Tepper JE, Warshaw AL, et al (1984) Intraoperative radiation therapy for patients with pancreatic carcinoma. World J Surg 8: 929

    Article  PubMed  CAS  Google Scholar 

  132. Sindelar WF, Kinsella TJ (1986) Randomized trial of intraoperative radiotherapy in unresectable carcinoma of the pancreas. Int J Radiat Oncol Biol Phys 12: 148

    Google Scholar 

  133. Bezzi M, Orsi F, Salvatori FM, et al (1994) Self-expandable nitinol stent for the management of biliary obstruction: long-term clinical results. J Vase Interv Radiol 5: 287

    Article  CAS  Google Scholar 

  134. Mathieson JR, McLoughlin RF, Cooperberg PL, et al (1994) Malignant obstruction of the common bile duct: long-term results of Gianturco-Rosch metal stents used as initial treatment. Radiology 192: 663

    PubMed  CAS  Google Scholar 

  135. Alden ME, Mohiuddin M (1994) The impact of radiation dose in combined external beam and intraluminal lr-192 brachytherapy for bile duct cancer. Int J Radiat Oncol Biol Phys 28: 945

    Article  PubMed  CAS  Google Scholar 

  136. Busse PM, Stone MD, Sheldon TA, et al (1989) Intraoperative radiation therapy for biliary tract carcinoma: results of a 5-year experience. Surgery 105: 724

    PubMed  CAS  Google Scholar 

  137. Shimizu T, Tanaka Y, Lijima M, et al (1994) Radiotherapy for advanced carcinoma of the gallbladder: special reference to IORT and hyperthermo-chemo-radiotherapy. Nippon Igaku Hoshasen Gakkai Zasshi 54: 269

    PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1995 Springer-Verlag/Wien

About this paper

Cite this paper

Schratter-Sehn, A.U. (1995). Radiotherapie maligner gastrointestinaler Tumoren. In: Schlag, P.M., Dittrich, C. (eds) Maligne gastrointestinale Tumoren. Angewandte Onkologie. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9417-1_22

Download citation

  • DOI: https://doi.org/10.1007/978-3-7091-9417-1_22

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-82716-1

  • Online ISBN: 978-3-7091-9417-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics