Summary
This report summarizes the results of our studies on the effects of prostacyclin (PGI2) on the outcome of global cerebral ischemia (GCI). GCI was produced for 15 and 20 min. In vivo dialysis of the hippocampus was used to determine the changes in extracellular concentrations of calcium (Ca+2e) and blood-brain barrier (BBB) permeability. Moreover, EEG and general physiological parameters were recorded. This was combined with morphological observations. PGI2 was infused continuously i.v. at a rate of 2 µg/kg/min. Rabbits with untreated GCI served as reference. Treatment with PGI2 significantly enhanced EEG recovery and normalization during recirculation, and reduced both the decrease in Ca+2e, and the BBB leakage. The number of ischemic neurons in the PGI2-treated rabbits was significantly lower than in the non-treated ones. PGI2 reduced brain edema. These data suggest that PGI2 may protect against postischemic brain damage, in part by inhibiting excessive calcium influx to neurons and in part by tightening of BBB.
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References
Gaudet RJ, Levine L (1979) Transient cerebral ischemia and brain prostaglandins. Biochem Biophys Res Comm 86: 893–901
Huczyński J, Kostka-Trąbka E, Sotowska W, Bieroń K, Grodzińska L, Dembińska-Kieć A, Pykosz-Mazur E, Pęczak E, Gryglewski RJ (1985) Double-blind controlled trial of the therapeutic effects of prostacyclin in patients with completed ischemic stroke. Stroke 16: 810–814
Kerckhoff van den W, Hossmann KA, Hossmann V (1983) No effect of prostacyclin on blood flow, regulation of blood flow and blood coagulation following global cerebral ischemia. Stroke 14: 724–730
Pluta R (1985) Influence of prostacyclin on early morphological changes in the rabbit brain after complete 20-min ischemia. J Neurol Sci 70: 305–316
Pluta R (1986) The influence of prostacyclin on the recovery of bioelectric cerebral activity after complete ischemia. Acta Neurol Scand 73: 44–54
Pluta R, Dydyk L (1987) Failure of prostacyclin effect on the reversal of early ultrastructural changes in cell nuclei of adrenal cortex after complete 15-min cerebral ischemia in rabbit. Exp Pathol 32: 163–168
Pluta R (1988) The effects of prostacyclin on early ultrastructural changes in the neuron nuclei of the motor cortex in rabbits after complete 20-min cerebral ischemia. Exp Mol Pathol 48: 161–173
Pluta R (1991) The effects of prostacyclin on early ultrastructural changes in the cytoplasm and nuclei of neuroglial cells following complete cerebral ischemia. J Hirnforsch 32: 175–184
Pluta R, Salińska E, Łazarewicz JW (1991) Prostacyclin attenuates in the rabbit hippocampus early consequences of transient complete cerebral ischemia. Acta Neurol Scand 83: 370–377
Sampaolo S, Cervós-Navarro J, Djouchadar D, Figols J (1987) Clinical and experimental evidence of microthrombosis in cerebral ischemia. In: Hartmann A, Kuschinsky W (eds) Cerebral ischemia and hemorrheology. Springer, Berlin Heidelberg New York, pp 386–393
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© 1994 Springer-Verlag
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Pluta, R. (1994). Complete Cerebral Ischemia, Prostacyclin Deficiency, and Therapeutic Possibilities. In: Ito, U., et al. Brain Edema IX. Acta Neurochirurgica, vol 60. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9334-1_81
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DOI: https://doi.org/10.1007/978-3-7091-9334-1_81
Publisher Name: Springer, Vienna
Print ISBN: 978-3-7091-9336-5
Online ISBN: 978-3-7091-9334-1
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