Summary
Atrial natriuretic peptide (ANP) regulates fluid and electrolyte homeostasis in the central nervous system. In this study, we evaluated the effects of ANP on brain edema, intracranial pressure (ICP) and cerebral energy metabolism in congenital hydrocephalus in rats. Brain edema, indicated by the longitudinal relaxation time (Tl), was evaluated by 1H-magnetic resonance imaging (MRI). The ICP was monitored with a miniature pressure-transducer with telemetric system. Cerebral energy metabolism, indicated by PCr/Pi ratio, was measured by 31P-magnetic resonance spectroscopy (MRS). The rats were given 10 μl of ANP in the left cerebral ventricle. Three different concentrations of ANP were given; 0.2 (group I), 2.0 (group II) and 20.0 (group III) jug/10 (il, respectively. 10 μl of saline was injected into the ventricle of the control group rats. There were no significant changes of ICP, Tl value and PCr/Pi ratio among the control group, group I and group II. In group III, in contrast, ICP decreased significantly at 20 minutes after ANP administration and stayed at this ICP level for 60 minutes. The Tl value decreased and PCr/Pi ratio increased 30 minutes after ANP administration. This study revealed that intraventricularly administered ANP could decrease ICP, reduce brain edema and improve the cerebral energy metabolism in rats with congenital hydrocephalus.
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© 1994 Springer-Verlag
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Minamikawa, J., Kikuchi, H., Ishikawa, M., Yamamura, K., Kanashiro, M. (1994). The Effects of Atrial Natriuretic Peptide on Brain Edema, Intracranial Pressure and Cerebral Energy Metabolism in Rat Congenital Hydrocephalus. In: Ito, U., et al. Brain Edema IX. Acta Neurochirurgica, vol 60. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9334-1_27
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DOI: https://doi.org/10.1007/978-3-7091-9334-1_27
Publisher Name: Springer, Vienna
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