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Brain Edema IX pp 76–78Cite as

The Role of Histamine in Brain Oedema Formation

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Part of the book series: Acta Neurochirurgica ((NEUROCHIRURGICA,volume 60))

Summary

The effects of histamine on the cerebral endothelial cells were studied. To determine if the extent of brain oedema formation could be reduced with histamine receptor antagonists, mepyramine (Hi-receptor blocker), metiamide, cimetidine and ranitidine (H2receptor antagonists) were administered at a dose of 5 mg/kg body weight 4, 2 and 0 h before the onset of experimental pneumothorax induced in newborn piglets. Mepyramine and ranitidine given 2 h before the induction of EBP prevented the accumulation of water, sodium and albumin in samples taken from the parietal cortex. In other experiments, carried out on Sprague-Dawley rats of CFY strain after permanent bilateral common carotid ligation (BCCL), the accumulation of water and sodium in the ischemic brain tissue could also be prevented in a dose dependent manner by intraperitoneal injections of ranitidine given 30 min before the surgery. Taken together, these results provide pharmacological evidence for the involvement of histamine receptors in the pathogenesis of brain oedema. Consequently, the use of histamine receptor blockers both in the prevention and in the treatment of brain oedema can be recommended.

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Author information

Authors and Affiliations

  1. Laboratory of Molecular Neurobiology, Institute of Biophysics, Biological Research Center, Temesvári krt 62, P.O. Box 521, 6701-Szeged, Hungary

    Ferenc Joó M.D. & Á. Tósaki

  2. Department of Pediatrics, Albert Szent-Györgyi Medical University, Szeged, Hungary

    J. Kovács

  3. Central Research Laboratory, Albert Szent-Györgyi Medical University, Szeged, Hungary

    P. Szerdahelyi

  4. Department of Pediatrics, Teaching Hospital, Makó, Hungary

    P. Temesvári

Authors
  1. Ferenc Joó M.D.
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  2. J. Kovács
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  3. P. Szerdahelyi
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  4. P. Temesvári
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  5. Á. Tósaki
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Editor information

Editors and Affiliations

  1. Department of Neurosurgery, Musashino Red-Cross Hospital, Tokyo, Japan

    Umeo Ito M.D. (Director and Neurosurgeon in Chief) (Director and Neurosurgeon in Chief)

  2. Institut für Chirurgische Forschung, Ludwig-Maximilians-Universität, München, Federal Republic of Germany

    Alexander Baethmann M.D. (Professor) (Professor)

  3. Max-Planck Institut für Neurologische Forschung, Köln, Federal Republic of Germany

    Konstantin-A. Hossmann M.D. (Professor) (Professor)

  4. Department of Neuropathology, Tokyo Medical and Dental University, Tokyo, Japan

    Toshihiko Kuroiwa M.D. (Associate Professor) (Associate Professor)

  5. Division of Neurosurgery, Medical College of Virginia, Richmond, Virginia, USA

    Anthony Marmarou Ph.D. (Professor) (Professor)

  6. Neurochirurgische Klinik, Ludwig-Maximilians-Universität, München, Federal Republic of Germany

    Hans-J. Reulen M.D. (Professor) (Professor)

  7. Department of Neurosurgery, Tokyo Women’s Medical College, Tokyo, Japan

    Kintomo Takakura M.D. (Professor) (Professor)

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© 1994 Springer-Verlag

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Joó, F., Kovács, J., Szerdahelyi, P., Temesvári, P., Tósaki, Á. (1994). The Role of Histamine in Brain Oedema Formation. In: Ito, U., et al. Brain Edema IX. Acta Neurochirurgica, vol 60. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9334-1_19

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  • DOI: https://doi.org/10.1007/978-3-7091-9334-1_19

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-9336-5

  • Online ISBN: 978-3-7091-9334-1

  • eBook Packages: Springer Book Archive

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