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Pharmacokinetics and Pharmacodynamics of Serum Glycerol in Patients with Brain Edema: Comparison of Oral and Intraveneous Administration

  • Conference paper
Brain Edema IX

Part of the book series: Acta Neurochirurgica ((NEUROCHIRURGICA,volume 60))

  • 202 Accesses

Summary

To clarify the pharmacokinetics and effect of ICP reduction of glycerol administered orally, the serum concentration of glycerol was measured by the enzymatic method and ICP was measured by the subdural balloon method in severe head injured patients with brain edema and increased ICP. Sequential change of serum glycerol concentration and its relationship to the reduction of ICP were analyzed. The results showed that the pharmacokinetics of glycerol through oral administration were similar to that of intravenous glycerol administration and the changes of ICP were also similar to that of intravenous glycerol administration. We determined that glycerol can be administered either per oral or per venous to obtain the same results for treatment of brain edema with raised ICP.

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References

  1. Node Y (1982) A study of glycerol on the reduction of raised intracranial pressure and its rebound phenomenon. J Nippon Med School 49: 752–758

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  2. Wald L, McLaurin S, Robert (1982) Oral glycerol for the treatment of traumatic intracranial hypertension. J Neurosurg 56:323–331

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Author information

Authors and Affiliations

  1. Department of Pharmacy, Kitasato University Hospital, 1-15-1, Sagamihara-shi, Kanagawa Prefect 228, Japan

    H. Tsuyusaki M.D., R. Kondo, S. Murase, T. Kobayashi & F. Tomonaga

  2. Emergency and Critical Care Medicine, Kitasato University Hospital, Kanagawa, Japan

    Y. Kitahara, S. Morii & T. Ohwada

  3. School of Phamaceutical Science, Kitasato University Hospital, Kanagawa, Japan

    Y. Yoshiyama

  4. Yamato Municipal Hospital, Yamato, Japan

    H. Takagi

Authors
  1. H. Tsuyusaki M.D.
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  2. R. Kondo
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  3. S. Murase
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  4. Y. Yoshiyama
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  5. T. Kobayashi
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  6. H. Takagi
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  7. Y. Kitahara
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  8. S. Morii
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  9. F. Tomonaga
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  10. T. Ohwada
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Editor information

Editors and Affiliations

  1. Department of Neurosurgery, Musashino Red-Cross Hospital, Tokyo, Japan

    Umeo Ito M.D. (Director and Neurosurgeon in Chief) (Director and Neurosurgeon in Chief)

  2. Institut für Chirurgische Forschung, Ludwig-Maximilians-Universität, München, Federal Republic of Germany

    Alexander Baethmann M.D. (Professor) (Professor)

  3. Max-Planck Institut für Neurologische Forschung, Köln, Federal Republic of Germany

    Konstantin-A. Hossmann M.D. (Professor) (Professor)

  4. Department of Neuropathology, Tokyo Medical and Dental University, Tokyo, Japan

    Toshihiko Kuroiwa M.D. (Associate Professor) (Associate Professor)

  5. Division of Neurosurgery, Medical College of Virginia, Richmond, Virginia, USA

    Anthony Marmarou Ph.D. (Professor) (Professor)

  6. Neurochirurgische Klinik, Ludwig-Maximilians-Universität, München, Federal Republic of Germany

    Hans-J. Reulen M.D. (Professor) (Professor)

  7. Department of Neurosurgery, Tokyo Women’s Medical College, Tokyo, Japan

    Kintomo Takakura M.D. (Professor) (Professor)

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© 1994 Springer-Verlag

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Tsuyusaki, H. et al. (1994). Pharmacokinetics and Pharmacodynamics of Serum Glycerol in Patients with Brain Edema: Comparison of Oral and Intraveneous Administration. In: Ito, U., et al. Brain Edema IX. Acta Neurochirurgica, vol 60. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9334-1_152

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  • DOI: https://doi.org/10.1007/978-3-7091-9334-1_152

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-9336-5

  • Online ISBN: 978-3-7091-9334-1

  • eBook Packages: Springer Book Archive

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