Skip to main content
SpringerLink
Log in

Pharmacokinetic Study of Mannitol in Subjects with Increased ICP

  • Conference paper
Brain Edema IX

Part of the book series: Acta Neurochirurgica ((NEUROCHIRURGICA,volume 60))

Summary

Six human subjects received mannitol as an introvenous dip (DIV) infusion. In each subject, the concentration of mannitol and serum osmolality were rapidly elevated during mannitol administration and reached the maximum at the end of mannitol administration. Then, it exponentially decreased. There was a strong positive correlation between mannitol concentration and extrinsic serum osmolality. The integrated values of mannitol concentration difference between the central (Cc) and the peripheral compartment (Pc) correlated with the changes of ICP reduction during mannitol administration. The results indicate that the changes of ICP reduction depend on the mannitol concentration difference between Cc and Pc.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  1. Cloyd JC, Snyder BD, Cleeremans B, Bundlie SR (1986) Mannitol pharmacokinetics and serum osmolality in dogs and humans. J Pharmacol Exp Ther 236: 301–306

    PubMed  CAS  Google Scholar 

  2. Domingnez R, Corcoran AC, Page IH (1947) Mannitol: kinetics of distribution, excretion, and utilization in human beings. J Lab Clin Med 32: 1192–1202

    Google Scholar 

  3. Goldwasser P, Fotino S (1984) Acute renal failure following massive mannitol infusion. Arch Intern Med 144: 2214–2216

    Article  PubMed  CAS  Google Scholar 

  4. Kullberg G, Sundbarg G (1976) Reduction of raised intracranial pressure recordings. In: Beks JWF, Bosch DA, Brock M (eds) Intracranial pressure 3. Springer, Berlin Heidelberg New York

    Google Scholar 

  5. Shenkin HA, Goluboff B, Haft H (1962) The use of mannitol for the reduction of intracranialpressure in intracranial surgery. J Neurosurg 19:897–901

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. School of Pharmaceutical Sciences, Kitasato University and Emergency and Critical Care Medicine, Kitasato University Hospital, Tokyo, Japan

    Teruaki Kobayashi M.D., T. Ichikawa, R. Kondo, Y. Yoshiyama, F. Tomonaga & T. Ohwada

Authors
  1. Teruaki Kobayashi M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. T. Ichikawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. R. Kondo
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Y. Yoshiyama
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. F. Tomonaga
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. T. Ohwada
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Neurosurgery, Musashino Red-Cross Hospital, Tokyo, Japan

    Umeo Ito M.D. (Director and Neurosurgeon in Chief) (Director and Neurosurgeon in Chief)

  2. Institut für Chirurgische Forschung, Ludwig-Maximilians-Universität, München, Federal Republic of Germany

    Alexander Baethmann M.D. (Professor) (Professor)

  3. Max-Planck Institut für Neurologische Forschung, Köln, Federal Republic of Germany

    Konstantin-A. Hossmann M.D. (Professor) (Professor)

  4. Department of Neuropathology, Tokyo Medical and Dental University, Tokyo, Japan

    Toshihiko Kuroiwa M.D. (Associate Professor) (Associate Professor)

  5. Division of Neurosurgery, Medical College of Virginia, Richmond, Virginia, USA

    Anthony Marmarou Ph.D. (Professor) (Professor)

  6. Neurochirurgische Klinik, Ludwig-Maximilians-Universität, München, Federal Republic of Germany

    Hans-J. Reulen M.D. (Professor) (Professor)

  7. Department of Neurosurgery, Tokyo Women’s Medical College, Tokyo, Japan

    Kintomo Takakura M.D. (Professor) (Professor)

Rights and permissions

Reprints and permissions

Copyright information

© 1994 Springer-Verlag

About this paper

Cite this paper

Kobayashi, T., Ichikawa, T., Kondo, R., Yoshiyama, Y., Tomonaga, F., Ohwada, T. (1994). Pharmacokinetic Study of Mannitol in Subjects with Increased ICP. In: Ito, U., et al. Brain Edema IX. Acta Neurochirurgica, vol 60. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9334-1_148

Download citation

  • DOI: https://doi.org/10.1007/978-3-7091-9334-1_148

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-9336-5

  • Online ISBN: 978-3-7091-9334-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation