Summary
The family Filoviridae contains extremely pathogenic human viruses causing a fulminating, febrile hemorrhagic disease. Filoviruses are enveloped, filamentous particles with a nonsegmented negative-strand RNA genome showing the gene arrangement 3′-NP-VP35-VP40-GP-VP30-VP24-L-5′. Genes are flanked by highly conserved transcriptional signals and are generally separated by variable intergenic regions. They are transcribed into monocistronic polyadenylated messenger RNAs which contain relatively long 5′ and 3′ untranslated regions. Seven structural proteins are encoded by the genome of which four form the helical nucleocapsid (NP-VP35-VP30-L), two are membrane-associated (VP40-VP24), and one is a transmembrane glycoprotein (GP). Comparison of filovirus genomes with those of other nonsegmented negative-strand RNA viruses suggest comparable mechanisms of transcription and replication and a common evolutionary lineage for all these viruses. Sequence analyses of single genes, however, showed that filoviruses are more closely related to paramyxoviruses, particularly human respiratory syncytial virus. These data support the concept of the taxonomic order Mononegavirales for all nonsegmented negative-strand RNA viruses and the classification of Marburg virus, Ebola virus, and Reston virus in the family Filoviridae, separate from the families Paramyxoviridae and Rhabdoviridae.
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References
Baron RC, McCormick JB, Zubeir OA (1983) Ebola hemorrhagic fever in southern Sudan: hospital dissemination and intrafamilial spread. Bull World Health Organ 6: 997–1003
Becker S, Feldmann H, Will C, Slenczka W (1992) Evidence for occurrence of filovirus antibodies in humans and imported monkeys: do subclinical filovirus infections occur worldwide? Med Microbiol Immunol 181: 43–55
Buchmeier MJ, DeFries RU, McCormick JB, Kiley MP (1983) Comparative analysis of the structural polypeptides of Ebola virus from Sudan and Zaire. J Infect Dis 147: 276–281
Cianciolo GJ, Copeland TD, Oroszlan S, Snyderman R (1985) Inhibition of lymphocyte proliferation by a synthetic peptide homologous to retroviral envelope proteins. Science 230: 453–455
Collins PL, Olmsted RA, Spriggs MK, Johnson PR, Buckler-White AJ (1987) Gene overlap and site-specific attenuation of transcription of the viral polymerase L gene of human respiratory syncytial virus. Proc Natl Acad Sci USA 84: 5134–5138
Cox NJ, McCormick JB, Johnson KM, Kiley MP (1983) Evidence for two subtypes of Ebola virus based on oligonucleotide mapping of RNA. J Infect Dis 147: 272–275
Devereux J, Haeberli P, Smithies O (1984) A comprehensive set of sequence anlysis programs for the VAX. Nucleic Acids Res 12: 387–395
Elango N (1989) The mumps virus nucleocapsid mRNA sequence and homology among the paramyxoviridae proteins. Virus Res 12: 77–86
Elliott LH, Kiley MP, McCormick JB (1985) Descriptive analysis of Ebola virus proteins. Virology 147: 169–176
Feldmann H, Mühlberger E, Randolf A, Will C, Kiley MP, Sanchez A, Klenk HD (1992) Marburg virus, a filovirus: messenger RNAs, gene order, and regulatory elements of the replication cycle. Virus Res 24: 1–19
Feldmann H, Will C, Schikore M, Slenczka W, Klenk H-D (1991) Glycosylation and oligomerization of the spike protein of Marburg virus. Virology 182: 353–356
Feldmann H, Wunder H, Huppertz S, Randolf A, Mahner F, Klenk H-D (1993) Characterization and expression of two membrane-associated virion structural proteins (VP40 and VP24) of Marburg virus. Virology (submitted)
Fisher-Hoch SP, Brammer L, Trappier SG, Hutwagner LC, Farrar BB, Ruo SL, Brown BG, Hermann LM, Perez-Oronoz GI, Goldsmith CS, Hanes MA, McCormick JB (1992) Pathogenic potential of filoviruses: role of geographic origin of primate host and virus strain. J Infect Dis 166: 753–763
Gear JSS, Cassel GA, Gear AJ, Trappler B, Clausen L, Meyers AM, Kew MC, Bothwell TH, Sher R, Miller GB, Schneider J, Koornhoff HJ, Comperts ED, Isaäcson M, Gear JHS (1975) Outbreak of Marburg virus disease in Johannesburg. Br Med J 4: 489–493
Geyer H, Will C, Feldmann H, Klenk H-D, Geyer R (1992) Carbohydrate structure of Marburg virus glycoprotein. Glycobiology 2: 299–312
Heymann DL, Weisfeld JS, Webb PA, Johnson KM, Cairns T, Berquist H (1980) Ebola hemorrhagic fever: Tandala Zaire, 1977–78. J Infect Dis 142: 373–376
ICTV (1991) The order Mononegavirales. Paramyxovirus Study Group of the Vertebrate Subcommittee. Arch Virol 117: 137–140
Jahrling PB (1991) Filoviruses and arenaviruses. In: Balows A (ed) Manual of clinical microbiology. American Society for Microbiology, Washington, D.C., pp 984–997
Jahrling PB, Geisbert TW, Galgard DW, Johnson ED, Ksiazek TG, Hall WC, Peters CJ (1990) Preliminary report: isolation of Ebola virus from monkeys imported to USA. Lancet 335: 502–505
Johnson BK, Ochen D, Oogo S, Gitau LG, Wambui C, Gichogo A, Libondo D, Tukei PM, Johnson ED (1986) Seasonal variation in antibodies against Ebola virus in Kenyan fever patients. Lancet i: 1160
Johnson KM, Lange JV, Webb PA, Murphy FA (1977) Isolation and partial characterization of a new virus causing acute hemorrhagic fever in Zaire. Lancet i:569–571
Johnson KM, Scribner CL, McCormick JB (1981) Ecology of Ebola virus: a first clue? J Infect Dis 143: 749–751
Kiley MP, Bowen ETW, Eddy GA, Isaäcson M, Johnson KM, McCormick JB, Murphy FA, Pattyn SR, Peters D, Prozesky OW, Regnery RL, Simpson DIH, Slenczka W, Sureau P, van der Groen G, Webb PA, Wulff H (1982) Filoviridae: a taxonomic home for Marburg and Ebola viruses? Intervirology 18: 24–32
Kiley MP, Cox NJ, Elliott LH, Sanchez A, DeFries R, Buchmeier MJ, Richman DD, McCormick JB (1988) Physicochemical properties of Marburg virus: evidence for three distinct virus strains and their relationship to Ebola virus. J Gen Virol 69: 1957–1967
Kiley MP, Wilusz J, McCormick JB, Keene JD (1986) Conservation of the 3’ terminal nucleotide sequence of Ebola and Marburg virus. Virology 149: 251–254
Kurilla MG, Stone HO, Keene JD (1985) RNA sequence and transcriptional properties of the 3’end of the Newcastle disease virus genome. Virology 145: 203–212
Leppert M, Kolakofsky D (1980) Effect of defective interfering particles on plus- and minus-strand leader RNAs in vesicular stomatitis virus infected cells. J Virol 35: 704–709
Leppert M, Rittenhouse L, Perrault J, Summers DF, Kolakofsky D (1979) Plus and minus strand leader RNAs in negative-strand virus-infected cells. Cell 18: 735–747
Martini GA (1971) Clinical syndrom. In: Martini GA, Siegert R (eds) Marburg virus disease, 1st edn. Springer, Berlin Heidelberg New York, pp 1–9
Martini GA, Siegert R (1971) Marburg virus disease, 1st edn. Springer, Berlin Heidelberg New York
MMWR (1990) Update: filovirus infection in animal handlers. MMWR 39: 221
MMWR (1990) Update: filovirus infections among persons with occupational exposure to nonhuman primates. MMWR 39: 266–267
MMWR (1990) Update: evidence for filovirus infection in an animal caretaker in a research/service facility. MMWR 39: 296–297
MMWR (1990) Update: filovirus infection associated with contact with nonhuman primates or their tissues. MMWR 39: 404–405
Mühlberger E, Sanchez A, Randolf A, Will C, Kiley MP, Klenk H-D, Feldmann H (1992) The nucleotide sequence of the L gene of Marburg virus, a filovirus: homologies to paramyxoviruses and rhabdoviruses. Virology 187: 534–547
Murphy FA, van der Groen G, Whitfield SG, Lange JV (1978) Ebola and Marburg virus morphology and taxonomy. In: Pattyn SR (ed) Ebola virus hemorrhagic fever, 1st edn. Elsevier/North-Holland, Amsterdam, pp 61–84
Needleman SB, Wunsch CD (1970) A general method applicable to the search for similarities in the amino acid sequence of two proteins. J Mol Biol 48: 443–453
Palmer AE, Allen AM, Tauraso NM, Shlokov A (1968) Simian hemorrhagic fever. I. Clinical and epizootiologic aspects of an outbreak among quarantined monkeys. Am J Trop Med Hyg 17: 404–412
Pattyn SR (1978) Ebola virus hemorrhagic fever, 1st edn. Elsevier/North-Holland, Amsterdam, pp 1–436
Peters D, Müller G, Slenczka W (1971) Morphology, development, and classification of Marburg virus. In: Martini GA, Siegert R (eds) Marburg virus disease, 1st edn. Springer, Berlin Heidelberg New York, pp 68–83
Sanchez A, Kiley MP (1987) Identification and analysis of Ebola virus messenger RNA. Virology 157: 414–420
Sanchez A, Kiley MP, Holloway BP, Auperin DD (1993) Sequence analysis of the Ebola virus genome: Organization, genetic elements, and comparison with the genome of Marburg virus. Virus Res (in press)
Sanchez A, Kiley MP, Holloway BP, McCormick JB, Auperin DD (1989) The nucleoprotein gene of Ebola virus: cloning, sequencing, and in vitro expression. Virology 170: 81–91
Sanchez A, Kiley MP, Klenk H-D, Feldmann H (1992) Sequence analysis of the Marburg virus nucleoprotein gene: comparison to Ebola virus and other non-segmented negative-strand RNA viruses. J Gen Virol 73: 347–357
Siegert R, Shu H-L, Slenczka W, Peters D, Müller G (1967) Zur Äthiologie einer unbekannten von Affen ausgegangenen Infektionskrankheit. Dtsch Med Wochenschr 92: 2341–2343
Slenczka W, Rietschel M, Hoffmann C, Sixl W (1984) Seroepidemiologische Untersuchungen über das Vorkommen von Antikörpern gegen Marburg- und Ebola-Virus in Afrika. Mitt Oesterr Ges Tropenmed Parasitol 6: 53–60
Smith CEG, Simpson DIH, Bowen ETW (1967) Fatal human disease from vervet monkeys. Lancet ii: 1119–1121
Smith DH, Johnson BK, Isaäcson M, Swanapoel R, Johnson KM, Kiley MP, Bagshawe A, Siongok T, Keruga WK (1982) Marburg-virus disease in Kenya. Lancet i: 816–820
Teepe RGC, Johnson BK, Ocheng D, Gichogo A, Langatt A, Ngindu A, Kiley M, Johnson KM, McCormick JB (1983) A probable case of Ebola virus hemorrhagic fever in Kenya. East Afr Med J 60: 718–722
van der Waals FJ, Pomeroy KL, Goudsmit J, Asher DM, Gajdusek DC (1986) Hemorrhagic fever virus infection in an isolated rainforest area of central Liberia. Limitations of the indirect immunofluorescence slide test for antibody screening in Africa. Trop Geogr Med 38: 209–214
Volchkov VE, Blinov VM, Netesov SV (1992) The envelope glycoprotein of Ebola virus contains an immunosuppressive-like domain similar to oncogenic retroviruses. FEBS Lett 305: 181–184
Will C, Mühlberger E, Linder D, Slenczka W, Klenk H-D, Feldmann H (1993) Marburg virus gene four encodes the virion membrane protein, a type I trans-membrane glycoprotein. J Virol 67: 1203–1210
World Health Organization (1978a) Ebola hemorrhagic fever in Zaire, 1976. Bull World Health Organ 56: 271–293
World Health Organization (1978b) Ebola hemorrhagic fever in Sudan, 1976. Bull World Health Organ 56: 247–270
World Health Organization (1979) Viral hemorrhagic fever surveillance. WER 54: 342–343
World Health Organization (1992) Viral hemorrhagic fever in imported monkeys. WER 67: 142
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Feldmann, H., Klenk, HD., Sanchez, A. (1993). Molecular biology and evolution of filoviruses. In: Kaaden, OR., Eichhorn, W., Czerny, CP. (eds) Unconventional Agents and Unclassified Viruses. Archives of Virology, vol 7. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9300-6_8
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DOI: https://doi.org/10.1007/978-3-7091-9300-6_8
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