Summary
We report our experience with lidocaine microinjection into the thalamus in 10 patients undergoing stereotactic thalamotomy for the treatment of Parkinsonian or non-Parkinsonian tremor. 18 injection sites in 4 patients with Parkinson’s disease and 22 sites in 6 patients with other forms of tremor have been compared with respect to the effect of microstimulation. In over two thirds of cases the test microinjection replicated the effects of microstimulation.
Long term follow up will be required to determine whether lesions made on the basis of lidocaine induced tremor suppression will result in a lower rate of tremor recurrence than those based on stimulation induced tremor suppression.
In those patients in whom stimulation induced tremor suppression occurs but tremor arrest cannot be produced with lidocaine microinjection, chronic thalamic stimulation may be an alternative for the long term control of tremor in these patients.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Myers RD (1966) Injection of solutions into cerebral tissue: Relation between volume and diffusion. Physiol Behav 1: 171–174
Martin JH (1991) Autoradiographic estimation of the extent of reversible inactivation produced by microinjection of lidocaine and muscimol in the rat. Neurosci Lett 127: 160–164
Sandkiller J, Maisch, Zimmerman M (1987) The use of local anaesthetic microinjections to identify central pathways: A quantitative evaluation of the time course and extent of the neuronal block. Exp Brain Res 68: 168–178
Tasker RR, Organ LW, Hawrylyshyn PA (1982) The thalamus and midbrain of man. Thomas, Baltimore, pp 304–308
Blond S, Siegfried J (1991) Thalamic stimulation for the treatment of tremor and other movement disorders. Acta Neurochir (Wien) [Suppl] 52: 109–111
Benabid AL, Pollak P, Gervason C, Hoffman D, Gao DM, Hommel M, Perret JE, deRougement J (1991) Long-term suppression of tremor by chronic stimulation of the ventral intermediate thalamic nucleus. Lancet 337: 403–406
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1993 Springer-Verlag Wien
About this paper
Cite this paper
Parrent, A.G., Tasker, R.R., Dostrovsky, J.O. (1993). Tremor Reduction by Microinjection of Lidocaine During Stereotactic Surgery. In: Meyerson, B.A., Broggi, G., Martin-Rodriguez, J., Ostertag, C., Sindou, M. (eds) Advances in Stereotactic and Functional Neurosurgery 10. Acta Neurochirurgica, vol 58. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9297-9_9
Download citation
DOI: https://doi.org/10.1007/978-3-7091-9297-9_9
Publisher Name: Springer, Vienna
Print ISBN: 978-3-7091-9299-3
Online ISBN: 978-3-7091-9297-9
eBook Packages: Springer Book Archive