Effects of Acute Isotonic Saline Administration on Serum Osmolality, Serum Electrolytes, Brain Water Content and Intracranial Pressure

  • Hector E. James
  • S. Schneider
Conference paper
Part of the Acta Neurochirurgica book series (NEUROCHIRURGICA, volume 57)


Albino rabbits who had undergone a cryogenic insult over the left parieto-occipital cortex 24 hours previously were analyzed for serum osmolality, serum electrolytes, brain water content, intracranial pressure (ICP), following a 3 hour baseline intravenous infusion of above maintenance isotonic saline, and compared to sham operated controls.

In the acute setting there was no difference in the serum osmolality and electrolytes between the subgroups. There was a significant increase in the water content of the white matter of the left hemisphere in the cold lesion group when compared to sham operated controls. Despite the intravenous fluid challenge, the ICP did not rise during the 3 hour experimental trial when compared to pre-trial values.

It is concluded that in the acute setting an isotonic fluid load is compensated without significant disturbances of the above measured parameters, and should not alter therefore intracranial dynamics per se, in acute resuscitation measures following brain insults.


Vasogenic brain edema intracranial hypertension isotonic saline infusion cerebral water content 


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Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • Hector E. James
    • 1
    • 2
  • S. Schneider
    • 1
  1. 1.Division of Neurosurgery, School of MedicineUniversity of CaliforniaSan DiegoUSA
  2. 2.Department of Pediatrics, School of MedicineUniversity of CaliforniaSan DiegoUSA

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