Summary
The authors present their results regarding the use of a buffered solution of glycerol 30%-sodium ascorbate 20% (GLIAS) for the treatment of brain oedema and intracranial hypertension. GLIAS was perfused intravenously in 80 patients with several types of brain oedema. In every patients serum and urinary osmolarity, diuresis, main blood and urine parameters, and ICP were monitored. Following GLIAS infusion an increase in plasma osmolarity was observed, changing the average basal value plus 13.4% after 15 min., 10.5% after 30’. At the same time there was a reduction of ICP and improvement in cerebral compliance. In each case there was a decrease in intracranial hypertension and brain oedema without significant collateral effects.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Cantore GP, Guidetti B, Virno M (1964) Oral glycerol for the reduction of intracranial pressure. J Neurosurg 21: 278–283
Crutchfield JS, Narayan RK, Robertson CS, Lloyd HM (1990) Evaluation of a fiber optic intracranial pressure monitor. J Neurosurg 72: 482–487
Di Giugno G, Rosa G (1984) Modificazioni idroelettrolitiche da diuretici osmotici e furosemide, utilizzati nel trattamento della ipertensione endocrina. Min Anest 50: 482–487
Garcia-Sola R, Gilsonz F, Chillon D (1989) Immediate and long term effects of mannitol and glycerol: a comparative experimental study. In: JT Hoff et al (eds), Intracranial pressure VII. Springer, Berlin Heidelberg, pp 451–453
Pitlich WH, Pirikitakuihir P, Painter MJ, Wessel HP (1982) Effects of glycerol and hyperosmolarity on intracranial pressure. Clin Pharmacol 31: 466–471
Tao RC, Nelly RE, Yashimura NN, Benjamin F (1985) Glycerol: its metabolism and use as intravenous energy source. JPEN 7: 479–488
Tourtellotte WW, Reinglass JL, Newkirk TA (1971) Cerebral dehydration action of glycerol. Historical aspects with emphasis on toxicity and intravenous administration. Clin Pharmacol Ther 13: 159–171
Virno M, Della Rocca L, Pecori-Giraldi J, Cantore GP (1966) Scomparsa dell’ematuria provocata dal glicerolo endovenoso nel coniglio mediante associazione glicerolo-ascorbato di sodio. Gazz Int Med Chir 51: 256–267
Yukio I, Donlin ML (1990) The molecular basis of brain injury and brain edema: the role of oxygen free radicals. Neurosurgery 27: 1–11
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1992 Springer-Verlag
About this paper
Cite this paper
Oppido, P.A. et al. (1992). Brain Oedema and Intracranial Hypertension Treatment by GLIAS. In: da Silva, A.M., Melo, A.R., Loew, F. (eds) Neurotraumatology: Progress and Perspectives. Acta Neurochirurgica, vol 55. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9233-7_12
Download citation
DOI: https://doi.org/10.1007/978-3-7091-9233-7_12
Publisher Name: Springer, Vienna
Print ISBN: 978-3-7091-9235-1
Online ISBN: 978-3-7091-9233-7
eBook Packages: Springer Book Archive