Skip to main content

Distribution of extraneuronal uptake1 in reproductive tissues: studies on cells in culture

  • Conference paper

Part of the book series: Journal of Neural Transmission ((NEURAL SUPPL,volume 34))

Summary

Cultures of stromal cells from pregnant mouse uterus, and an FL cell line derived from human amnion, displayed significant capacities to O- methylate noradrenaline. O-methylation was inhibited in the stromal cells by uptake1-inhibitors, and in the FL cell line by uptake2 inhibitors. These findings are discussed in terms of the distribution and possible functional importance of catecholamine metabolising systems in the female reproductive system.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • de la Lande IS, Parker DAS, Procter C, Marino V (1987) Cocaine inhibits extraneuronal O-methylation of exogenous noradrenaline in nasal and oral tissues of the rabbit. Life Sci 41: 2463–2468

    Article  PubMed  Google Scholar 

  • de la Lande Is, Parker DAS, Marino V (1989) O-methylation of noradrenaline is linked with an uptake process which resembles uptake! in dental pulp. J Neurochem 52 [Suppl]: 16

    Google Scholar 

  • de la Lande IS, Marino V, Kennedy JA, Parker DAS (1990) Further evidence that the extraneuronal uptake of noradrenaline in rabbit dental pulp is similar to uptake i. Eur J Pharmacol 183: 1147–1148

    Article  Google Scholar 

  • Garfield RE (1986) Structural studies on innervation of non pregnant rat uterus. Am J Physiol 251: C41–54

    Google Scholar 

  • Graefe K-H, Stefano FJE, Langer SZ (1973) Prefential metabolism of (-)-3H- noradrenaline through the deaminated glycol in the rat vas deferens. Biochem Pharmacol 22: 1147–1160

    Article  CAS  Google Scholar 

  • Kennedy JA (1991) Effect of catechol oestrogens on extraneuronal metabolism of noradrenaline by rabbit uterine endometrium and myometrium. Naunyn- Schmiedebergs Arch Pharmacol 343: 266–270

    PubMed  CAS  Google Scholar 

  • Kennedy JA, de la Lande IS (1986) Effect of progesterone on the metabolism of noradrenaline in the rabbit uterine endometrium and myometrium. Naunyn- Schmiedebergs Arch Pharmacol 333: 368–376

    Google Scholar 

  • Kennedy JA, de la Lande (1987) Characteristics of cocaine-sensitive accumulation and O-methylation of noradrenaline by rabbit endometrium. Naunyn-Schmiedebergs Arch Pharmacol 336: 148–154

    Google Scholar 

  • Kennedy JA, de la Lande IS (1988) Catecholamine inactivation in uterine tissues; changes in pregnancy in the rat. Clin Exp Physiol Pharmacol 15: 675–680

    Google Scholar 

  • Lavranos TC, Seamark RF (1989) Addition of steroids to embryo-uterine monolayer co-culture enhances embryo survival and implantation in vitro. Reprod Fertil Dev 1: 41–46

    Article  PubMed  CAS  Google Scholar 

  • Mondschein JS, Hersey RM, Dey SK, Davis D, Weisz J (1985) Catechol estrogen formation by pig blastocysts: biochemical characterization of estrogen-2/4- hydroxylase and correlation with aromatase activity during the preimplantation period. Endocrinology 117: 2339–2346

    Article  PubMed  CAS  Google Scholar 

  • Nicholas TE, Strum JM, Angelo IS, Junod AF (1974) Site and mechanism of uptake of 3H-l-noradrenaline by isolated perfused rat lungs. Circ Res 35: 670–680

    PubMed  CAS  Google Scholar 

  • Parker DAS, de la Lande IS, Proctor C, Marino V, Lam NX, Parker I (1987) Cocaine-sensitive O-methylation of noradrenaline in dental pulp; comparison with the rabbit ear artery. Naunyn-Schmiedebergs Arch Pharmacol 336: 32–39

    Google Scholar 

  • Robertson SA, Searmark RF (1990) Granulocyte macrophage colony stimulating factor ( GM-CSF) in the murine reproductive tract; stimulation by seminal factors. Reprod Fertil Dev 2: 359–368

    Google Scholar 

  • Schömig E, Schönfeld C-L (1990) Extraneuronal noradrenaline transport (uptake2) in a human cell line. Naunyn-Schmiedebergs Arch Pharmacol 341: 404–410

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1991 Springer-Verlag

About this paper

Cite this paper

de la Lande, I.S., Marino, V., Lavranos, T., Kennedy, J.A., Parker, D.A.S., Seamark, R.F. (1991). Distribution of extraneuronal uptake1 in reproductive tissues: studies on cells in culture. In: Bönisch, H., Graefe, KH., Langer, S.Z., Schömig, E. (eds) Recent Advances in Neuropharmacology. Journal of Neural Transmission, vol 34. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9175-0_5

Download citation

  • DOI: https://doi.org/10.1007/978-3-7091-9175-0_5

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-82300-2

  • Online ISBN: 978-3-7091-9175-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics