Abstract
It is estimated that there are now over one million persons who have used heroin regularly in the United States and possibly two million that have used heroin at some time. Of these, it is estimated that at least 500,000 are “hard-core” heroin addicts, defined as users of multiple, regular self-administered doses of short-acting opiates such as heroin each day for one year or more, with the development of tolerance, physical dependence and drug seeking behavior, thus, addiction. (42,43,54)
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References
Albeck, H., Woodfield, S., Kreek, M.J.: Quantitative and pharmacokinetic analysis of naloxone in plasma using high performance liquid chromatography with electrochemical detection and solid phase extrac tion. J. Chromatog. 488: 435–445, 1989.
Albeck, H., Woodfield, S., Wahlstrom, A., Kreek, M.J.: Naloxone pharmacokinetics in man following an intravenous dose. In: Problems of Drug Dependence. 1990: Proceedings of the 52nd Annual Scientific Meeting of the Committee on Problems of Drug Dependence. Harris, L.S. ed., NIDA Research Monograph Series, Rockville, MD, in press 1991.
Bodner, G., Albeck, H., Soda, K.M., Kreek, M.J.: Modulation of natural killer cell activity: Possible role of hypothalamic-pituitary-adrenal hormones. In: New Leads in Opioid Research. Eds. Van Ree, J.M., Mulder, A.H., Wiegant, V.M., and Van Wimersma Greulanus, T.B., Excerpta Medica, Amsterdam 330–331, 1990.
Bodner, G., Soda, K.M., Kennedy, J., Kreek, M.J.: Modulation of NK Activity: role of neuroendocrine status. In: Problems of Drug Dependence. 1990: Proceedings of the 52nd Annual Scientific Meeting of the Committee on Problems of Dru_ Dependence. Harris, L.S. ed., NIDA Research Monograph Series. Rockville, MD, in press 1991.
Bowen, D.V., Smit, A.L.C. and Kreek, M.J.: Fecal excretion of methadone and its metabolites in man: Application of GC-MS. In: Advances in Mass Spectrometry, N.R. Daly, ed., Philadelphia, PA: Heyden & Son, Inc., 7B:1634–1639, 1978.
Culpepper-Morgan, J.A., Holt, P.R., Kreek, M.J.: Colonic opiate receptors change with age: Preliminary data. In: Problems of Drug Dependence, 1987: Proceedings of the 49th Annual Scientific Meeting of the Committee on Problems of Drug Dependence. Harris, L.S. ed., NIDA Research Monograph Series, Rockville, MD DHHS Publications No. (ADM)88–1564 81:267, 1988.
Culpepper-Morgan, J., Kreek, M.J., Holt, P.R., La Roche, D., Zhang, J., O’Bryan, L.: Orally administered kappa as well as mu opiate delay gastrointestinal transit time in the guinea pig. Life Sciences, 42: 2073–2077, 1988.
Cushman, P. and Kreek, M.J.: Some endocrinologic observations in narcotic addicts. In: Narcotic and the Hypothalamus, E. Zimmerman and R. George, eds., New York, NY: Raven Press, 161–173, 1974.
Cushman, P., Kreek, M.J. and Gordis, E.: Ethanol and methadone in man: A possible drug interaction. Drug and Alc. Dep., 3: 35–42, 1978.
Des Jarlais, D.C., Friedman, S.R., Novick, D.M., Sotheran, J.L., Thomas, P., Yancovitz, S.R., Mildvan, D., Weber, J. Kreek, M.J., Maslansky, R., Bartelme, S.,Spira, T. Marmor, M. HIV I Infection among intravenous drug users in Manhattan, New York City 1977 to 1987. JAMA 261: 1008–1012, 1989.
Des Jarlais, D.C., Marmor, M., Cohen, H., Yancovitz, S., Garber, J., Friedman, S., Kreek, M.J., Miescher, A., Khuri, E., Friedman, S.M., Rothenberg, R., Echenberg, D., O’Malley, P.O., Braff, E., Chin, J., Burtenol, P., Sikes, R.K.: Antibodies to a retrovirus etiologically associated with Acquired Immunodeficiency Syndrome (AIDS) in populations with increased incidences of the syndrome. Morbidity and Mortality Weekly Report, 33: 377–379, 1984.
Dole, V.P. and Kreek, M.J.: Methadone plasma level: Sustained by a reservoir of drug in tissue. Proc. Natl. Acad. Sci., 70: 10, 1973.
Dole, V.P., Nyswander, M.E. and Kreek, M.J.: Narcotic blockade. Arch. Intern. Med., 118: 304–309, 1966.
Hachey, D.L., Kreek, M.J. and Mattson, D.H.: Quantitative analysis of methadone in biological fluids using deuterium-labeled methadone and GLC-chemical-ionization mass spectrometry. J. Pharm. Sci., 66: 1579–1582, 1977.
Hachey, D.L., Mattson, D.H. and Kreek, M.J.: Quantitation of methadone in biological fluids using deuterium labeled internal standards. In: Proceedings of the Second International Conference on Stable Isotopes, E.R. Klein and P.D. Klein, eds., ERDA-CONF-751027, Springfield, VA: National Technical Information Source, U.S. Dept. of Commerce, 518–523, 1976.
Hachey, D.L., Nakamura, K., Kreek, M.J. and Klein, P.D.: Analytical techniques for using multiple, simultaneous stable isotopic tracers. In: Stable Isotopes, H.L. Schmidt, H. Forstel and K. Heinzinger, eds., Amsterdam: Elsevier Scientific Publishing Company, 235–239, 1982.
Hahn, E.F., Lahita, R., Kreek, M.J., Duma, C., Inturrisi, C.E.: Naloxone radioimmunoassay: an improved antiserum. J. Pharm. Pharmacol., 35:, 833–836, 1983.
Kaufmann, C.A., Kreek, M.J., Karoum, F. and Chuang, L.W.: Depression during methadone withdrawal: No role for betaphenylethylamine. Drug and Alcohol Dependence, 13: 21–29, 1984.
Kaufmann, C.A., Kreek, M.J., Raghunath, J., Arns, P.: Methadone, monoamine oxidase and depression: Opioid dist-ribution and acute effects on enzyme activity.Biol. Psychiatry, 18: 1007–1021, 1983.
Kennedy, J.A., Hartman, N., Sbriglio, R., Khuri, E., Kreek, M.J.: Metyrapone-induced withdrawal symptoms. Brit J Addict 85: 1133–1140, 1990.
Klein, P.D., Hachey, D.L., Kreek, M.J. and Schoeller, D.A.: Stable isotopes: Essential tools in biological and medical research. In: Stable Isotopes: Applications in Pharmacology. Toxicology and Clinical Research, T.A. Baillie, ed., Baltimore, MD: University Park Press, 3–14, 1978.
Kosten, T.R., Kreek, M.J., Raghunath, J., Kleber, H.D.: A preliminary study of beta-endorphin during chronic naltrexone maintenance treatment in ex-opiate addicts. Life Sciences 39: 55–59, 1986a.
Kosten, T.R., Kreek, M.J., Raghunath, J., Kleber, H.D.: Cortisol levels during chronic naltrexone maintenance treatment in ex-opiate addicts. Biological Psychiatry. 21: 217–220, 1986b.
Kosten, T.R., Kreek, M.J., Swift, C., Carney M.K., Ferdinands, L.: Beta-endorphin levels in CSF during methadone maintenance. Life Sciences, 41: 1071–1076, 1987.
Kreek, M.J.: Medical safety, side effects and toxicity of methadone. Proceedings of the Fourth National Conference on Methadone Treatment, NAPAN-NIMH, 171–174, 1972.
Kreek, M.J.: Medical safety and side effects of methadone in tolerant individuals. J. Amer. Med. Assn., 223: 665–668, 1973a.
Kreek, M.J.: Physiological implications of methadone treatment. In: Methadone Treatment Manual, U.S. Dept. of Justice (USGPO) #2700–00227, Washington, D.C.: 85–91, 1973b.
Kreek, M.J.: Plasma and urine levels of methadone. N.Y. State J. Med., 73: 2773–2777, 1973c.
Kreek, M.J.: Pharmacologie modalities of therapy: Methadone maintenance and the use of narcotic antagonists. In: Heroin dependency: Medical, economic and social aspects, B. Stimmel, ed., New York, NY: Stratton Intercontinental Medical Book Corp., 232–290, 1975.
Kreek, M.J.: The role of qualitative and quantitative analysis of drugs and their metabolites in maternal–neonatal studies. In: National Institute on Drug Abuse Symposium on Comprehensive Health Care for Addicted Families and Their Children, Services Research Report (USGPO), #017–024–00598–3, Washington, DC:67–73, 1977.
Kreek, M.J.: Medical complications in methadone patients. Ann. N.Y. Acad. Sci., 311: 110–134, 1978a.
Kreek, M.J.: Effects of drugs and alcohol on opiate disposition and action. In: Factors Affecting the Action of Narcotics, M.W. Adler, L. Manara and R. Saminin, eds., New York, NY: Raven Press, 717–739, 1978b.
Kreek, M.J.: Methadone disposition during the perinatal period in humans. Pharmac. Biochem. Behay., 11, Suppl.: 7–13, 1979a.
Kreek, M.J.: Methadone in treatment: Physiological and pharmacological issues. In: Handbook on Drug Abuse, R.L. Dupont, A. Goldstein and J. O’Connell, eds., NIDA-ADAMHA-DEW-ODAP-Executive Office of the President, 57–86, 1979b.
Kreek, M.J.: Metabolic interactions between opiates and alcohol. Ann. N.Y. Acad.Sci., 362: 36–49, 1981.
Kreek, M.J.: Disposition of narcotics in the perinatal period. In: Publication of AMERSA and The Career Teacher Program in Alcohol and Drug Abuse, 3: 7–10, 1981–82.
Kreek, M.J.: Opioíd disposition and effects during chronic exposure in the perinatal period in man. In: Journal of Addictive Diseases, B. Stimmel, ed., New York, NY: The Haworth Press, Inc., 1:21–53, 1982.
Kreek, M.J.: Physiological and Pharmacological tiveness of methadone. In: Research in Narcotic Addiction: State of the Art, J.R. B.S. Brown, and D. Czechowicz, eds.,National Abuse Monograph, DHHS Pub. # (ADM) 83–1281, 95–114, 1983.
Kreek, M.J.: Opioid interactions with alcohol. Journal of Addictive Diseases New York, NY: The Haworth Press, 3: 35–46, 1984.
Kreek, M.J.: Drug interactions with methadone in humans. In: Strategies for Research on the Interactions of Drugs of Abuse, NIDA Research Monograph 68 Braude, M.C. and Ginzburg, H.M., eds., Rockville, MD., 68:193–225, 1986a.
Kreek, M.J.: Exogenous Opioids: Drug-Disease Interactions, Advances in Pain Research and Therapy, eds. Foley, K.M., Inturrisi, C.E., New York, NY: Raven Press, 8: 201–210, 1986b.
Kreek, M.J.: Multiple Drug Abuse Patterns and Medical Consequences. In: Psychopharmacology: The Third Generation of Progress. Meltzer, H.Y., ed. Raven Press, New York, NY 1597–1604, 1987a.
Kreek, M.J.: Tolerance and Dependence - Implications for the pharmacological treatment of addiction. In: Problems of Drug Dependence, 1986; Proceedings of the 48th Annual Scientific Meeting of The Committee on Problems of Drug Dependence. Harris, L.S., ed., NIDA Research Monograph Series, Rockville, MD, DHHS Publication No.(ADM) 87–1508 76:53–61, 1987b.
Kreek, M.J.: Opiate-ethanol interactions: Implications for the biological basis and treatment of combined addictive diseases. In: Problems of Drug Dependence. 1987: Proceedings of the 49th Annual Scientific Meeting of the Committee on Problems of Drug Dependence. Harris, L.S., ed. NIDA Research Monograph Series Rockville, MD DHHS Publication No. (ADM)88–1564 81:428–439, 1988.
Kreek, M.J.: Immunological approaches to clinical issues in drug abuse. In: Problems of Drug Dependence, 1988: Proceedings of the 50th Annual Scientific Meeting of the Committee on Problems of Drug Dependence. Harris, L.S. ed., NIDA Research Monograph Series, Rockville, MD DHHS Publication No. (ADM)89–1605 90:77–86, 1989.
Kreek, M.J.: Drug interactions in humans related to drug abuse and its Treatment. Modern Methods in Pharmacology 6: 265–282, 1990a.
Kreek, M.J.: Historical and medical aspects of methadone maintenance treatment: Effectiveness in treatment of heroin addiction and implications of such treatment in the setting of the AIDS epidemic. Evaluation of Different Programmes for Treatment of Drug Addicts Adamsson, C., Jansson, B., Rydberg, U., Westrin, C., (Eds.), Medicinska Forskningsradet, Stockholm, Sweden, 61–76, 1990b.
Kreek, M.J.: Methadone maintenance treatment for heroin addiction. The Effectiveness of Drug Abuse Treatment: Dutch and American Perspectives Platt, J.J., Kaplan, C.D., McKim, P.J., (Eds.), Malabar, Florida: Krieger Publishing Co. 275–293, 1990c.
Kreek, M.J.: HIV infection and parenteral drug abuse: ethical issues in diagnosis, treatment, research and the maintenance of confidentiality. In: Proceedings of the Third International Congress on Ethics in Medicine–Nobel Conference Series. P. Allebeck, B. Jansson, eds. Raven Press, New York, NY 181–187, 1990d.
Kreek, M.J.: Immune function in heroin addicts and former heroin addicts in treatment: pre/post AIDS epidemic. Current Chemical and Pharmacological Advances on Drugs of Abuse Which Alter Immune Function and Their Impact Upon HIV Infection: Pham, P.T.K., and Rice, K., eds. NIDA Research Monograph Series, Rockville, MD 96:192–219, 1990e.
Kreek, M.J.: Multiple Drug Abuse Patterns: Recent trends and associated medical consequences. Advances in Substance Abuse: Behavioral and Biological Research, Volume 4, Jessica Kingsley Publishers Ltd., London, England. In press 1990f.
Kreek, M.J.: Neuroendocrine (HPA) and Gastrointestinal Effects of Opiate Antagonists: Possible Therapeutic Application. In: Problems of Drug Dependence 1990: Proceedings of the 52nd Annual Scientific Meeting of the Committee on Problems of Drug Dependence. Harris, L.S. ed., NIDA Research Monograph Series. Rockville, MD, in press 1991a.
Kreek, M.J.: Immunological Function in Active Heroin Addicts and Methadone Maintained Former Addicts: Observations and Possible Mechanisms. In: Problems of Drug Dependence, 1990; Proceedings of the 52nd Annual Scientific Meeting of the Committee on Problems of Drug Dependence. Harris, L.S. ed., NIDA Research Monograph Series, Rockville, MD, in press 1991b.
Kreek, M.J.: Using methadone effectively: achieving goals by application of laboratory, clinical, and evaluation research any by development of innovative programs. Improving Drug Abuse Treatment: Pickens, R., Leukefeld, C., Schuster, R. eds. NIDA Research Monograph Series Rockville, MD in press, 1991c.
Kreek, M.J., Bencsath, F.A., Fanizza, A. and Field, F.H.: Effects of liver disease on fecal excretion of methadone and its unconjugated metabolites in maintenance patients: Quantitation by direct probe chemical ionization mass spectrometry. Biomed Mass Spectrm., 10: 544–549, 1983.
Kreek, M.J., Bencsath, F.A. and Field, F.H.: Effects of liver disease on urinary excretion of methadone and metabolites in maintenance patients: Quantitation by direct probe chemical ionization mass spectrometry. Biomedical Mass Spectrometry, 7: 385–395, 1980.
Kreek, M.J., Brown, L.T., Bernstein, W.J. and Harte, E.H.: Estrogen treatment alters narcotic disposition in the rat. In: Proceedings of the 1979 International Narcotic Research Conference, E.L. Way, ed., New York: Pergamon Press, 405–407, 1980.
Kreek, M.J., Des Jarlais, D.C., Trepo, C.L., Novick, D.M., Abdul-Quader, A., Raghunath, J.: Contrasting prevalence of delta hepatitis markers in parenteral drug abusers with and without aids. J Infect Dis, 162: 538–541, 1990.
Kreek, M.J., Dodes, L., Kane, S., Knobler, J. and Martin, R.: Long-term methadone maintenance therapy: Effects on liver function. Ann. Intern. Med., 77: 598–602, 1972.
Kreek, M.J., Garfield, J.W., Gutjahr, C.L. and Giusti, L.M.: Rifampin-induced methadone withdrawal. New Engl. J. Med., 294: 1104–1106, 1976.
Kreek, M.J., Gutjahr, C.L., Bowen, D.V. and Field, F.H.: Fecal excretion of methadone and its metabolites: A major pathway of elimination in man. In: Critical Concerns in the Field of Drug Abuse: Proceedings of the Third National Drug Abuse Conference, A. Schecter, H. Alksne and E. Kaufman, eds., New York, NY: Marcel Dekker, Inc., 1206–1210, 1978.
Kreek, M.J., Gutjahr, C.L., Garfield, J.W., Bowen, D.V. and Field, F.H.: Drug interactions with methadone. Ann. N.Y. Acad. Sci., 281: 350–370, 1976.
Kreek, M.J., Hachey, D.L. and Klein, P.D.: Stereoselective disposition of methadone in man. Life Sci., 24: 925–932, 1979.
Kreek, M.J. and Hartman, N.: Chronic use of opioids and antipsychotic drugs: Side effects, effects on endogenous opioids and toxicity. Ann. N.Y. Acad. Sci., 398: 151–172, 1982.
Kreek, M.J., Kalisman, M., Irwin, M., Jaffery, N.F. and Scheflan, M.: Biliary secretion of methadone and methadone metabolites in man. Res. Comm. Chem. Path. Pharmacol., 29: 67–78, 1980.
Kreek, M.J., Khuri, E., Fahey, L., Miescher, A., Arns, P., Spagnoli, D., Craig, J., Millman, R., Harte, E.: Long term follow-up studies of the medical status of adolescent former heroin addicts in chronic methadone maintenance treatment: Liver disease and immune status. In: Problems of Drug Dependence, 1985; Proceedings of the 47th Annual Scientific Meeting of The Committee on Problem of Drug Dependence. Harris, L.S., ed., NIDA Research Monograph Series Rockville, MD., DHHS Publication No.(ADM) 86–1448 67: 307–309, 1986.
Kreek, M.J., Khuri, E., Flomenberg, N., Albeck, H., Ochshorn, M.: Immune status of unselected methadone maintained former heroin addicts. International Narcotics Research Conference 1989 (INRC), Quirion, R., Jhamandas, K., Gianoulakis, C., eds., Alan R. Liss, Inc., New York, NY, 445–448, 1989.
Kreek, M.J., Khuri, E. and Joseph, H.: A new “heroin epidemic” ? Ann. Intern. Med., 83: 420–421, 1975.
Kreek, M.J., Oratz, M. and Rothschild, M.A.: Hepatic extraction of long-and short-acting narcotics in the isolated perfused rabbit liver. Gastroenterology, 75: 88–94, 1978.
Kreek, M.J., Raghunath, J., Plevy, S., Hamer, D., Schneider, B., and Hartman, N.: ACTH, cortisol and beta-endorphin response to metyrapone testing during chronic methadone maintenance treatment in humans. Neuropeptides, 5: 277–278, 1984.
Kreek, M.J., Rothschild, M.A., Oratz, M., Mongelli, J. and Handley, A.C.: Acute effects of ethanol on hepatic uptake and distribution of narcotics in the isolated perfused rabbit liver. Hepatology, 1: 419–423, 1981.
Kreek, M.J., Schecter, A.J., Gutjahr, C.L. and Hecht, M.: Methadone use in patients with chronic renal disease. Drug and Alcohol Depend., 5: 197–205, 1980.
Kreek, M.J., Wardlaw, S.L., Friedman, J., Schneider, B. and Frantz, A.G.: Effects of chronic exogenous opioid administration on levels of one endogenous opioíd (beta-endorphin) in man. Advances in Endogenous and Exogenous Opioids, Simon E. and Takagi, H. eds., Tokyo, Japan: Kodansha Ltd. Publishers, 364366, 1981.
Kreek, M.J., Wardlaw, S.L., Hartman, N., Raghunath, J., Friedman, J., Schneider, B. and Frantz, A.G.: Circadian rhythms and levels of beta-endorphin, ACTH, and cortisol during chronic methadone maintenance treatment in humans. Life Sciences, Sup. I, 33: 409–411, 1983.
Nakamura, K., Hachey, D.L., Kreek, M.J., Irving, C.S. and Klein, P.D.: Quantitation of methadone enantiomers in humans using stable isotope-labeled 2H3,2H5, 2H8 methadone. J. Pharm. Sci., 71: 39–43, 1982.
Nakamura, K., Kreek, M.J., Hachey, D.L., Irving, C.S. and Klein, P.D.: Studies on disposition of dl-methadone in former heroin addicts by the multiple deuterium labeling method. Proceedings of the Japanese Society for Medical Mass Spectrometry, 6: 119–124, 1981.
Novick, D.M., Des Jarlais, D.C., Kreek, M.J., Spira, T.J., Friedman, S.R., Gelb, A.M., Stenger, R.J., Schable, C.A., Kalyanaraman, V.S.: The specificity of antibody tests for human immunodeficiency virus in alcohol and parenteral drug abusers with chronic liver disease. Alcoholism: Clinical and Experimental Research 12, 687–690, 1988.
Novick, D.M., Farci, P. Croxson, S.T., Taylor, M.B., Schneebaum, C.W., Lai, E.M., Bach, N. Senie, R.T., Gelb, A.M., Kreek, M.J.: Hepatitis delta virus and human immunodeficiency virus antibodies in parenteral drug abusers who are hepatitis B surface antigen positive. J. Infect. Dis., 158: 795–803, 1988.
Novick, D.M., Khan, I., Kreek, M.J.: Acquired immunodeficiency syndrome and infection with hepatitis viruses in individuals abusing drugs by injection. United Nations Bulletin on Narcotics, 38: 15–25, 1986.
Novick, D.M., Kreek, M.J., Arns, P.A. Lau, L.L., Yancovitz, S.R., and Gelb, A.M.: Effects of severe alcoholic liver disease on the disposition of methadone in maintenance patients. Alcoholism: Clin. Exp. Res., 9: 349–354, 1985.
Novick, D., Kreek, M.J., Des Jarlais, D., Spira, T.J., Khuri, E.T., Raghunath, J., Kalyanaraman, V.S., Gelb, A.M., and Miescher, A.: Antibody to LAV, the putative agent of AIDS, in parenteral drug abusers and methadone-maintained patients: Abstract of clinical research findings: Therapeutic, historical, and ethical aspects. In: Problems of Drug Dependence, 1985: Proceedings of the 47th Annual Scientific Meeting of The Committee on Problems of Drug Dependence. Harris, L.S., ed.,NIDA Research Monograph Series., Rockville, MD., DHHS Publication No. (ADM)86–1448 67:318–320, 1986.
Novick, M., Kreek, M.J., Fanizza, A.M., Yancovitz, S.R., Gelb, A.M. and Stenger, R.J.: Methadone disposition in patients with chronic liver disease. Clin.Pharmacol. Ther., 30: 353–362, 1981.
Novick, D.M., Ochshorn, M., Ghali, V., Croxson, T.S., Mercer, W.D., Chiorazzi, N., Kreek, M.J.: Natural Killer Cell Activity and Lymphocyte Subsets in Parenteral Heroin Abusers and Long-term Methadone Maintenance Patients. J. Pharm Exper Ther. 250: 606–610, 1989.
Novick, D.$4., Ochshorn, M., Kreek, M.J.: In vivo and in vitro studies of opiates and cellular immunity in narcotic addicts. In: Drugs of Abuse, Immunity and Immunodeficiency. Friedman, Herman, eds., Plenum Press, New York. In press 1991.
Novick, D.M., Trigg, H.L., Des Jarlais, D.C., Friedman, S.R., Vlahov, D., Kreek, M.J.: Cocaine injection and ethnicity in parenteral drug users during the early years of the human immunodeficiency virus (HIV) epidemic in New York City. J. Med. Virol. 29: 181–185, 1989.
Ochshorn, M., Kreek, M.J., Hahn, E.F., Novick, D.M.: High Concentrations of naloxone lower natural killer (NK) activity. In: Problems of Drug Dependence, 1987: Proceedings of the 49th Annual Scientific Meeting of the Committee on Problems of Drug Dependence. Harris, L.S. ed., NIDA Research Monograph Series, Rockville, MD DHHS Publication No. (ADM)88–1564, 81:338, 1988.
Ochshorn, M., Kreek, M.J., Khuri, E., Fahey, L., Craig, J., Aldana, M.C., Albeck, H.: Normal and abnormal Natural Killer (NK) activity in methadone maintenance treatment patients. In: Problems of Drug Dependence, 1988: Proceedings of the 50th Annual Scientific Meeting of the Committee on Problems of Drug Dependence. Harris, L.S. ed., NIDA Research Monograph Series, Rockville, MD DHHS Publication No. (ADM) 89–1605, 90:369, 1989.
Ochshorn, M., Novick, D.M., Kreek, M.J.: In vitro studies of methadone effect on natural killer (NK) cell activity. Israel J of Med Sci 26: 421–425, 1990.
Pond, S.M., Kreek, M.J., Tong, T.G., Raghunath, J.: Benowitz, Altered methadone pharmkokinetics in methadone-maintained pregnant women. J of Pharm. & Exper. Thera., 233: 1–6, 1985.
Ragavan, V.V., Wardlaw, S.L., Kreek, M.J., Frantz, A.G.: Effect of chronic naltrexone and methadone administration on brain immunoreactive beta-endorphin in the rat. Neuroendocrinology, 37: 266–268, 1983.
Rubenstein, R.B., Kreek, M.J., Mbawa, N., Wolff, W.I., Korn, R. and Gutjahr, C.L. and Wolff, W.I.: Human spinal fluid methadone levels. Drug and Alc. Dep., 3: 103–106, 1978.
Stimmel, B. and Kreek, M.J.: Pharmacologic actions of heroin. In: Heroin dependency: Medical, economic and social aspects, B. Stimmel, ed., New York, NY: Stratton Intercontinental Medical Book Corp., 71–87, 1975a.
Stimmel, B. and Kreek, M.J.: Dependence, tolerance and withdrawal. In: Heroin dependency: Medical, economic and social aspects, B. Stimmel, ed., New York, NY: Stratton Intercontinental Medical Book Corp., 88–97, 1975b.
Tong, T.G., Benowitz, N.L. and Kreek, M.J.: Methadone-disulfiram interaction during methadone maintenance J. Clin. Pharmacol., 20: 506–513, 1980.
Tong, T.G., Pond, S.M., Kreek, M.J., Jaffery, N.F. and Benowitz, N.L.: Phenytoin-induced methadone withdrawal. Ann. Intern. Med., 94: 349–351, 1981.
Unterwald, E.M., Kreek, M.J.: Alterations in the expression of brain opioid receptors during senescence. In: New Leads in Opioid Research Eds: Van Ree, Mulder, Wiegant and Van Wimersma Greidanus, pgs. 200–201, 1990a.
Unterwald, E.M., and Kreek, M.J.: Age-related changes in the expression of brain opioid receptors. Society for Neuroscience Abstracts, 16: 368, 1990b.
Unterwald, E.M., Nyberg, F., Terenius, L., Kreek, M.J.: Distribution of opioid peptides in brain and GI tract: Age and species-specific differences. In: Problems of Drug Dependence, 1990: Proceedings of the 52nd Annual Scientific Meeting of the Committee on Problems of Drug Dependence. Harris, L.S. ed., NIDA Research Monograph Series, Rockville, MD DHHS Publication No. (ADM) 91–1753 105:408–409, 1990.
Zhang, J.S;, Plevy, S., Albeck, H., Culpepper-Morgan. J., Friedman, J., Kreek, M.J.: Effects of age on distribution of preproenkephalin-like mRNA in the gastrointestinal tract of the guinea pig. Advances in the Biosciences: Proceedings of 1988 INRC meeting 75: 349–350, 1989.
Ziring, B., Brown, L. and Kreek, M.J.: Effects of route of administration on methadone disposition in the rat. In: Problems of Drug Dependence, 1980, Proceedings of the 42nd Annual Scientific Meeting of the Committee on Problems of Drug Dependence, L.S. Harris, ed., NIDA Research Monograph Series, Rockville, MD DHHS Publication No. 34:145–151, 1981.
Ziring, B.S., Kreek, M.J. and Brown, L.T.: Methadone disposition following oral versus parenteral dose administration in rats during chronic treatment. Drug Alc. Depend., 7: 311–318, 1981.
Ziring, B., Shepperd, S., and Kreek, M.J.: Reversed phase thin-layer chromatography for the separation of betaendorphin, beta-lipotropin and enkephalins. Int. J. Peptide Protein Res., 22: 32–38, 1983.
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Kreek, M.J. (1991). Methadone Maintenance Treatment for Harm Reduction Approach to Heroin Addiction. In: Loimer, N., Schmid, R., Springer, A. (eds) Drug Addiction and AIDS. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9173-6_19
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