Apolipoproteins in children with familial history of myocardial infarction

  • K. Widhalm


There is a great interest whether offsprings from families with manifest coronary heart disease can be discriminated from children without any family history. For this reason we studied serum lipids, lipoproteins and apoproteins in 291 offsprings from 152 fathers who had a myocardial infarction before the age of 55 years, in comparison with 283 healthy age matched controls. Statistical analysis reveals marked differences between the groups, showing that HDL-cholesterol, LDL-cholesterol and total cholesterol/HDL-cholesterol are the best discriminators. However, apolipoproteins AI and B are very good discriminators in the group < 20 years and the group > 20 years, respectively. The ratio AI/B is different in both age groups (p < 0.01 vs. 0.05).

However, there is no evidence that apolipoproteins add more information in order to discriminate between risk and non-risk families. More long-term follow-up seems to be necessary and appropriate statistical models should be used in order to support the hypothesis that apoproteins are better indicators for later cardiovascular risk than lipoproteins.


Apolipoproteins in children myocardial infarction cardiovascular disease risk factors risk and non-risk families 


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  1. 1.
    Avogaro P, Bittolo GB, Cazzolato G, Grimel GB, Belluzzi F (1978) Plasma levels of apolipoprotein AI and apolipoprotein B in human atherosclerosis. Artery 4: 385–394Google Scholar
  2. 2.
    Brunzell JB, Sniderman AD, Albers JJ, Kwiterovich PO Jr (1984) Apoproteins B and AI in coronary artery disease in humans. Arteriosclerosis 4: 79–83PubMedCrossRefGoogle Scholar
  3. 3.
    De Baecker G, Hulstaert F, De Munck K, Rosseneu M, Van Parijs L, Dramaix M (1986) Serum lipids and apoproteins in students whose parents suffered prematurely from a myocardial infarction. Am Heart J 112: 478–484CrossRefGoogle Scholar
  4. 4.
    Freedman DS, Srinivasan SR, Shear CL, Franklin FA, Webber LS, Berenson GS (1986) The relation of apolipoproteins AI and B in children to parental myocardial infarction. N Engl J Med 315: 721–726PubMedCrossRefGoogle Scholar
  5. 5.
    Lee J, Lauer RM, Clarke WR (1986) Lipoproteins in the progeny of young men with coronary artery disease: children with increased risk. Pediatrics 78: 330–337PubMedGoogle Scholar
  6. 6.
    Morrison JA, Khoury P, Melles MS, Kelly KA, Glueck CJ (1980) Identifying CHD risk factors in children: intrafamilial lipoprotein correlations. Prey Med 9: 484–495CrossRefGoogle Scholar
  7. 7.
    Newman WP, Freedmann DS, Cresanta JL, Williamson GD, Webber LS, Berenson GS (1986) Relation of serum lipoprotein levels and systolic blood pressure to early atherosclerosis. N Engl J Med 314: 138–144PubMedCrossRefGoogle Scholar
  8. 8.
    Schmidt GB, Wasserman AG, Muesing RA, Schlesselman SE, Larosa JC, Ross AM (1984) Lipoprotein and apolipoprotein levels in angiographically defined coronary artery disease in humans. Arteriosclerosis 4: 79–83CrossRefGoogle Scholar
  9. 9.
    Schrott HG, Clarke WR, Wiebe DA (1979) Increased coronary mortality in relatives of hypercholesterolemia school children. The Muscatine Study. Circulation 59: 320–326PubMedGoogle Scholar
  10. 10.
    Sniderman A, Shapiro S, Marpole D, Skinner B, Tang B, Kwiterovich PO Jr (1980) Association of coronary atherosclerosis with hyperapobetalipoproteinemia (increased protein but normal cholesterol levels in human plasma low density (ß) lipoproteins). Proc Natl Acad Sci USA 77: 604–608PubMedCrossRefGoogle Scholar
  11. 11.
    Sniderman AD, Teng B, Genest J, et al (1985) Familial aggregation and early expression of hyperapobetalipoproteinemia. Am J Cardiol 55: 291–295PubMedCrossRefGoogle Scholar
  12. 12.
    Stary HC (1989) Evolution and progression of atherosclerotic lesions in coronary arteries of children and young adults. Arteriosclerosis [Suppl 1, 9]: 1–19; 1–32Google Scholar
  13. 13.
    Sveger T, Fex G, Borgas N (1987) Hyperlipidemia in school children with family histories of premature coronary heart disease. Acta Paediatr Scand 76: 311–315PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag/Wien 1991

Authors and Affiliations

  • K. Widhalm
    • 1
  1. 1.Department of PediatricsUniversity of ViennaViennaAustria

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