Apolipoproteins in children with familial history of myocardial infarction
There is a great interest whether offsprings from families with manifest coronary heart disease can be discriminated from children without any family history. For this reason we studied serum lipids, lipoproteins and apoproteins in 291 offsprings from 152 fathers who had a myocardial infarction before the age of 55 years, in comparison with 283 healthy age matched controls. Statistical analysis reveals marked differences between the groups, showing that HDL-cholesterol, LDL-cholesterol and total cholesterol/HDL-cholesterol are the best discriminators. However, apolipoproteins AI and B are very good discriminators in the group < 20 years and the group > 20 years, respectively. The ratio AI/B is different in both age groups (p < 0.01 vs. 0.05).
However, there is no evidence that apolipoproteins add more information in order to discriminate between risk and non-risk families. More long-term follow-up seems to be necessary and appropriate statistical models should be used in order to support the hypothesis that apoproteins are better indicators for later cardiovascular risk than lipoproteins.
KeywordsApolipoproteins in children myocardial infarction cardiovascular disease risk factors risk and non-risk families
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