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Apolipoproteins and coronary heart disease

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Apolipoproteins in Lipid Disorders

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Summary

Clinical and experimental studies on apolipoprotein composition and atherogenicity are reviewed including case control, angiographic, prospective, and familial studies. Recent studies investigated the value of apolipoprotein measurements in the assessment of coronary hard disease risk. Most of the studies indicate that apo AI and B are strong CHD risk predictors. Apo B seems to be more strongly associated with cardiovascular risk than LDL-C or HDL-C levels. Another result was that the apolipoprotein levels are good indicators of the presene or absence of CHD. Apo B is a good indicator of the severity of disease.

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References

  1. Assmann G (ed) (1989) Lipid metabolism disorders and coronary heart disease. MMV Medizin Verlag, München

    Google Scholar 

  2. Avogaro P, Bittolo Bon G, Cazzalato G (1979) Are apolipoproteins better discriminators than lipids for atherosclerosis? Lancet is 901–903

    Google Scholar 

  3. Avogaro P, Bittolo Bon G, Cazzolato G, Rovai E (1980) Relationship between apolipoproteins and chemical components of lipoproteins in survivors of myocardial infarction. Atherosclerosis 37: 69–76

    Article  PubMed  CAS  Google Scholar 

  4. Barbir M, Wile D, Trayner I, Aber VR, Thompson GR (1988) High prevalence of hypertriglyceridemia and apolipoprotein abnormalities in coronary artery disease. Br Heart J 60: 397–403

    Article  PubMed  CAS  Google Scholar 

  5. Bittolo Bon G, Cazzolato G, Saccardi M, Kostner GM, Avogaro P (1984) Total plasma apo E and high density lipoprotein apo E in survivors of myocardial infarction. Atherosclerosis 53: 69–75

    Google Scholar 

  6. Boerwinkle E, Utermann G (1988) Simultaneous effects of the apo-lipoprotein E polymorphism on apolipoprotein E, apolipoprotein B and cholesterol metabolism. Am J Hum Genet 42: 104–112

    CAS  Google Scholar 

  7. Brunzell J, Mazzone T, Motulsky A, Albers JJ (1982) Abnormalities in high density lipoprotein composition in familial combined hyperlipidemia. Arteriosclerosis 2: 416–417

    Google Scholar 

  8. Brunzell JD, Albers JJ, Chait A (1983) Plasma lipoproteins in familial combined hyperlipidemic and monogenic familial hypertrigylceridemia. J Lipid Res 24: 147–155

    PubMed  CAS  Google Scholar 

  9. De Backer G, Hulstaert F, De Munck K, Rosseneu M, Van Parijs L, Damaix M (1986) Serum lipids and apolipoprotein in students whose parents suffered prematurely from a myocardial infarction. Am Heart J 112: 478–484

    Article  PubMed  Google Scholar 

  10. De Backer G, Rosseneu M, Deslypere JP (1982) Discriminative value of lipids and apolipoproteins in coronary heart disease. Atherosclerosis 42: 197–203

    Article  PubMed  Google Scholar 

  11. Deslypere JP, De Backer G, Rosseneu M, Vermeulen A (1981) Lipid and apoprotein levels in myocardial infarction survivors: a case-control study. Acta Cardiol 27: 95–102

    CAS  Google Scholar 

  12. Durrington PN, Hant L, Ishola M, Kane J, Stephens WP (1986) Serum apolipoproteins AI and B and lipoproteins in middle aged men with and without previous myocardial infarction. Br Heart J 56: 206–212

    Article  PubMed  CAS  Google Scholar 

  13. Freedman DS, Srinivasan SR, Shear CL, Franklin FA, Webber LS, Berenson GS (1986) The relation of apolipoproteins AI and B in children to parenteral myocardial infarction. N Engl J Med 315: 721–726

    Article  PubMed  CAS  Google Scholar 

  14. Gordon DJ, Rifkind B (1989) High density lipoprotein — the clinical implications of recent studies. N Engl J Med 321: 1311–1316

    Article  PubMed  CAS  Google Scholar 

  15. Grundy S, Vega G (1990) Role of apolipoprotein levels in clinical practice. Arch Int Med 150: 1579–1582

    Article  CAS  Google Scholar 

  16. Hamsten A, Walldius G, Szamosi A, Dahlen G, de Faire U (1986) Relationship of angiographically defined coronary artery disease to serum lipoproteins and apolipoproteins in young survivors of myocardial infarction. Circulation 73: 1097–1110

    CAS  Google Scholar 

  17. Ishikawa T, Fidge N, Thelle DS, Forde OH, Miller NE (1978) The Tromso Heart Study. Serum apolipoprotein AI concentration in relation to future coronary heart disease. Eur J Clin Invest 8: 179–182

    Google Scholar 

  18. James RW, Martin B, Pometta D, Grab D (1986) Apoprotein D in a healthy male population and in male myocardial infarction patients and their male first degree relatives. Atherosclerosis 60: 49–53

    Article  PubMed  CAS  Google Scholar 

  19. Kostner GM (1983) Apoproteins and lipoproteins of human plasma, significance in health and in disease. Adv Lipid Res 20: 1–43

    PubMed  CAS  Google Scholar 

  20. Kostner GM, Avogaro P, Cazzolato G (1981) Lipoprotein Lp(a) and the risk for myocardial infarction. Atherosclerosis 38: 51–61

    Article  PubMed  CAS  Google Scholar 

  21. Kottke BA, Zinsmeister A, Holmes D, Kneller R, Hallaway B, Mao S (1986) Apilipoproteins and coronary artery disease. Mayo Clin Proc 61: 313–320

    PubMed  CAS  Google Scholar 

  22. Kukita H,1 Hiwada K, Kokubu T (1984) Serum apolipoprotein AI, All and B levels and their discriminative values in relatives of patients with coronary artery disease. Atherosclerosis 51: 261–267

    Google Scholar 

  23. Lehtonen A, Marniemi J, Inberg M, Maatela J, Alanen E, Nuttymaki K (1986) Levels of serum lipids, apolipoproteins apoAI and B and pseudocholinesterase activity and their discriminative value in patients with coronary bypass operation. Atherosclerosis 59: 215–221

    Article  PubMed  CAS  Google Scholar 

  24. Maciejko JJ, Holmes DR, Kottke BA, Zinsmeister AR, Dinh DM, Mao SJ (1983) Apolipoprotein AI as a marker of angiographically assessed coronary artery disease. N Engl J Med 309: 385–389

    Article  PubMed  CAS  Google Scholar 

  25. Miller NE (1987) Associations of high lipoprotein subclasses and apolipoproteins with ischemic heart disease and coronary atherosclerosis. Am Heart J 113: 589–597

    Article  PubMed  CAS  Google Scholar 

  26. Murai A, Miyahara T, Fujimoto N (1986) Lp(a) lipoprotein as a risk factor for coronary heart disease and cerebral infarction. Atherosclerosis 59: 199–204

    Article  PubMed  CAS  Google Scholar 

  27. Naito HK (1985) The association of serum lipids, lipoproteins and apolipoproteins with coronary artery disease assessed by coronary arteriography. Ann NY Acad Sci 454: 230–238

    Article  PubMed  CAS  Google Scholar 

  28. Reinhart R, Gani K, Arndt M, Broste S (1990) Apolipoproteins AI and B as predictors of angiographically defined coronary artery disease. Arch Int Med 150: 1629–1633

    Article  CAS  Google Scholar 

  29. Rhoads GG, Dahlen G, Berg K (1986) Lp(a) lipoprotein as a risk factor for myocardial infarction. JAMA 256: 2540–2544

    Article  PubMed  CAS  Google Scholar 

  30. Riesen WF, Mordasini R, Salzmann C, Theler A, Gurtner MP (1980)

    Google Scholar 

  31. Apoproteins and lipids as discriminators of severity of coronary heart disease. Atherosclerosis 37: 157–162

    Google Scholar 

  32. Salonen JP, Salonen R, Penttila I (1985) Serum fatty acids, apolipoprotein, selenium and vitamin antioxidants and the risk of death from coronary artery disease. Am J Cardiol 56: 226–231

    Article  PubMed  CAS  Google Scholar 

  33. Sniderman AD, Wolfson C, Teng B, Franklin FA, Bachorik PS, Kwiterovich PO (1982) Association of hyperapobetalipoproteinemia with endogenous hypertriglyceridemia and atherosclerosis. Ann Intern Med 97: 833–839

    PubMed  CAS  Google Scholar 

  34. Wiklund 0, Fager G, Olofsson SO, Wilhelmsson C, Bondgers G (1980) Serum apolipoprotein levels in relation to acute myocardial infarction: determination of apolipoprotein B. Atherosclerosis 37: 631–636

    Google Scholar 

  35. Zenker G, Koltringer P, Bone G (1986) Lipoprotein(a) as a strong indicator for cerebrovascular disease. Stroke 17: 942–945

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Endocrinology, University of Gent, B-9000 Gent, Belgium

    Dr. J. P. Deslypere

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  1. Dr. J. P. Deslypere
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Editor information

Editors and Affiliations

  1. Brugge, Belgium

    Maryvonne Rosseneu

  2. Wien, Austria

    Kurt Widhalm

  3. Mannheim, Federal Republic of Germany

    Jochen Jarausch

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© 1991 Springer-Verlag/Wien

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Deslypere, J.P. (1991). Apolipoproteins and coronary heart disease. In: Rosseneu, M., Widhalm, K., Jarausch, J. (eds) Apolipoproteins in Lipid Disorders. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9148-4_3

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  • DOI: https://doi.org/10.1007/978-3-7091-9148-4_3

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-82273-9

  • Online ISBN: 978-3-7091-9148-4

  • eBook Packages: Springer Book Archive

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