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Interleukine zur Therapie schwerer Infektionen

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Part of the book series: Intensivmedizinisches Seminar ((INTENSIVM.SEM.,volume 3))

Zusammenfassung

Interleukine sind eine Gruppe von löslichen glykosilierten Proteinen, die reaktiv auf Antigen- oder Mitogenstimulation von Monozyten, Makrophagen, T- und B-Lymphozyten gebildet werden. Auf solche Reize modifizieren sie die zelluläre Antwort als Entzündungsmediatoren (Chemotaxis, Fieber u. a.) und als interzelluläre Informationsmoleküle, die zur Zellproliferation und Zelldifferenzierung von immunkompetenten Zellen führen. Um ihrer Herkunft und ihrer Wirkung gerecht zu werden, bezeichnete man diese Faktoren als Interleukine (IL). Im Laufe der Zeit fand man jedoch, daß sowohl die Bildung als auch die Wirkung der Interleukine nicht auf Leukozyten beschränkt sind.

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Literatur

  1. Bermudez LE, Stevens P, Kolonoski P, Wu M, Young LS (1989) Treatment of experimental disseminated Mycobacterium avium complex infection in mice with recombinant IL-2 and tumour necrosis factor. J Immunol 143 (9): 2996–3000

    PubMed  CAS  Google Scholar 

  2. Brezinschek HP, Faessler R, Klocker H, Kroemer G, Sgonc R, Dietrich H, Jakober R, Wick G (1990) Analysis of the immune-endocrine feedback loop in the avian system and its alteration in chickens with spontaneous autoimmune thyroiditis. Eur J Immunol (in press)

    Google Scholar 

  3. Carter KC, Gallagher G, Baillie A J, Alexander J (1989) The induction of protective immunity to Leishmania major in the BALB/c mouse by interleukin 4 treatment. Eur J Immunol 19 (4): 779–782

    Article  PubMed  CAS  Google Scholar 

  4. Czuprynski CJ, Brown JF, Young KM, Cooley AJ, Kurtz RS (1988) Effects of murine recombinant interleukin 1 alpha on the host response to bacterial infection. J Immunol 140 (3): 962–968

    PubMed  CAS  Google Scholar 

  5. Daniels HM, Meager A, Eddleston AL, Alexander GJ, Williams R (1990) Spontaneous production of tumor necrosis factor alpha and interleukin-1 beta during interferon-alpha treatment of chronic HBV infection. Lancet 335 (8694): 875–877

    Article  PubMed  CAS  Google Scholar 

  6. Donahue RE, Seehra J, Metzger M (1988) Human IL-3 and GM-CSF act synergistically in stimulating hematopoiesis in primates. Science 241: 1820–1823

    Article  PubMed  CAS  Google Scholar 

  7. Feng ZY, Louis J, Kindler V, Pedrazzini T, Eliason JF, Behin R, Vassalli P (1988) Aggravation of experimental cutaneous leishmaniasis in mice by administration of interleukin-3. Eur J Immunol 18 (8): 1245–1251

    Article  PubMed  CAS  Google Scholar 

  8. Grau GE, Kindler V, Piguet PF, Lambert PH, Vassalli P (1988) Prevention of experimental cerebral malaria by anticytokine antibodies. J Exp Med 168 (4): 1499–1504

    Article  PubMed  CAS  Google Scholar 

  9. Haeuber D (1989) Recent advances in the management of biotherapy-related side-effects: flu like syndrome. Oncol Nurs Forum 16 [Suppl 6]: 35–41

    PubMed  CAS  Google Scholar 

  10. Hulsebos LH, Choromanski L, Kuhn RE (1989) The effect of interleukin-2 on parasitemia and myocarditis in experimental Chagas disease. J Protozool 36 (3): 293–298

    PubMed  CAS  Google Scholar 

  11. Jablons D, Bolton E, Mertins S, Rubin M, Pizzo P, Rosenberg SA, Lotze MT (1990) IL-2 based immunotherapy alters circulating neutrophil Fc receptor expression and chemotaxis. J Immunol 144 (9): 3630–3636

    PubMed  CAS  Google Scholar 

  12. Jeevan A, Asherson GL (1988) Recombinant interleukin-2 limits the replication of Myobacterium lepraemurium and Myobacterium bovis BCG in mice. Lymphokine Res 7 (2): 129–140

    PubMed  CAS  Google Scholar 

  13. Kohl S, Loo LS, Drath DB, Cox P (1989) Interleukin-2 protects neonatal mice from lethal herpes simplex virus infection: a macrophage-mediated, gamma interferon-induced mechanism. J Infect Dis 159 (2): 239–247

    Article  PubMed  CAS  Google Scholar 

  14. Kurtz RS, Young KM, Czuprynski CJ (1989) Separate and combined effects of recombinant interleukin-1 alpha and gamma interferon on antibacterial resistence. Infect Immun 57 (2): 553–558

    PubMed  CAS  Google Scholar 

  15. Mazingue C, Cottrez-Detoeuf F, Louis J, Kweider M, Auriault C, Capron A (1989) In vitro and in vivo effects of interleukin-2 on the protozoan parasite leishmania. Eur J Immunol 19 (3): 487–491

    Article  PubMed  CAS  Google Scholar 

  16. Maoleekoonpairoj S, Mittelman A, Savona S, Ahmed T, Puccio C, Gafney E, Skelos A, Arnold P, Coombe N, Baskind P (1989) Lack of protection against bacterial infections in patients with advanced cancer treated by biologic response modifiers. J Clin Microbiol 27 (10): 2305–2308

    PubMed  CAS  Google Scholar 

  17. McCabe RE, Oster S (1989) Current recommendations and future prospects in the treatment of toxoplasmosis. Drugs 38 (6): 973–987

    Article  PubMed  CAS  Google Scholar 

  18. McIntyre KW, Unowsky J, DeLorenzo W, Benjamin W (1989) Enhancement of antibacterial resistence of neutropenic, bone marrow-suppressed mice by interleukin-1 alpha. Infect Immun 57 (1): 48–54

    PubMed  CAS  Google Scholar 

  19. Moskophidis D, Fang L, Gossmann J, Lehmann-Gruber F (1989) Mechanism of recovery from acute virus infection. IX. Clearance of lymphocytic choriomeningitis ( LCM) virus from the feet of mice undergoing LCM virus-specific delayed-type hypersensitivity reaction. J Gen Virol 70: 3305–3316

    Article  PubMed  Google Scholar 

  20. Murray HW, Oca MJ, Granger AM, Schreiber RD (1989) Requirement for T-cells and effect of lymphokines in successful chemotherapy for an intracellular infection. Experimental visceral leishmaniasis. J Clin Invest 83 (4): 1253–1257

    Article  PubMed  CAS  Google Scholar 

  21. Nakamura S, Minami A, Fujimoto K, Kojima T (1989) Combination effect of recombinant human interleukin-1 alpha with antimicrobial agents. Antimicrob Agents Chemother 33 (10): 1804–1810

    PubMed  CAS  Google Scholar 

  22. Perrin P, Joffret ML, Leclerc C, Oth D, Sureau P, Thibodeau L (1988) Interleukin2 increases protection against experimental rabies. Immunobiology 177 (2): 199–209

    PubMed  CAS  Google Scholar 

  23. Reddy PG, Blecha F, Minocha HC, Anderson GA, Morrill JL, Fedorka-Cray PJ, Baker PE (1989) Bovine recombinant interleukin-2 augments immunity and resistance to bovine herpes virus infection. Vet Immunol Immunopathol 23: 61–74

    Article  PubMed  CAS  Google Scholar 

  24. Reed SG, Pihl DL, Grabstein KH (1989) Immune deficiency in chronic Trypanosoma cruzi infection. Recombinant IL-1 restores Th function for antibody production. J Immunol 142 (6): 2067–2071

    PubMed  CAS  Google Scholar 

  25. Reisinger EC, Kern P, Ernst M, Bock P, Flad HD, Dietrich M and the German DTC Study Group (1990) Inhibition of HIV progression by dithiocarb. Lancet 335: 679–682

    Article  PubMed  CAS  Google Scholar 

  26. Roll JT, Young KM, Kurtz RS, Czuprynski CJ (1990) Human rTNF alpha augments anti-bacterial resistance in mice: potentiation of its effects by recombinant human rIL-1 alpha. Immunology 69 (2): 316–322

    PubMed  CAS  Google Scholar 

  27. Rosenberg SA, Lotze MT, Yang JC, Aebersold PM, Linehan WM, Seipp CA, White DE (1989) Experience with the use of high dose interleukin-2 in the treatment of 652 cancer patients. Ann Surg 210 (4): 474–485

    Article  PubMed  CAS  Google Scholar 

  28. Silver GM, Gamelli RL, O’Reilly M, Hebert JC (1990) The effect of interleukin1 alpha on survival in a murine model of burn wound sepsis. Arch Surg 125 (7): 922–925

    Article  PubMed  CAS  Google Scholar 

  29. Snydman DR, Sullivan B, Gill M, Gould JA, Parkinson DR, Atkins MB (1990) Nosocomial sepsis associated with interleukin-2. Ann Intern Med 112 (2): 102–107

    PubMed  CAS  Google Scholar 

  30. Thijs LG, Hack CE, Strack van Schijndel RJ, Nuijens JH, Wolbink GJ, Eerenberg-Belmer AJ, Van der Vall H, Wagstaff J (1990) Activation of the complement system during immunotherapy with recombinant IL-2. Relation to the development of side effects. J Immunol 144 (6): 2419–2424

    PubMed  CAS  Google Scholar 

  31. Vadhan Raj S, Buescher S, LeMaistre A (1988) Stimulation of haematopoiesis in patients with bone marrow failure and in patients with malignancy by recombinant human granulocyte-macrophage colony-stimulating factor. Blood 72: 134–141

    PubMed  CAS  Google Scholar 

  32. Van der Meer JW, Barza M, Wolff SM, Dinarello CA (1988) A low dose of recombinant interleukin-1 protects granulocytopenic mice from lethal gramnegative infection. Proc Natl Acad Sci 85 (5): 1620–1623

    Article  PubMed  Google Scholar 

  33. Wirth JJ, Kierszenbaum F, Zlotnik A (1989) Effects of IL-4 on macrophage functions: increased uptake and killing of a protozoan parasite (Trypanosoma cruzi). Immunolgy 66 (2): 296–301.

    CAS  Google Scholar 

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© 1991 Springer-Verlag/Wien

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Reisinger, E.C., Brezinschek, H.P. (1991). Interleukine zur Therapie schwerer Infektionen. In: Deutsch, E., et al. Infektionen auf Intensivstationen. Intensivmedizinisches Seminar, vol 3. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9130-9_19

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  • DOI: https://doi.org/10.1007/978-3-7091-9130-9_19

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-82253-1

  • Online ISBN: 978-3-7091-9130-9

  • eBook Packages: Springer Book Archive

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