Dexamethasone Does not Influence Infarct Size but Causes Haemorrhage in Baboons with Cerebral Infarcts

  • A. Hartmann
  • G. Ebhardt
  • Th. Rommel
  • A. Meuer
Conference paper
Part of the Acta Neurochirurgica book series (NEUROCHIRURGICA, volume 51)

Summary

15 baboons with permanent occlusion of the left MCA were randomly treated with dexamethasone (n = 8; 1 mg/kg day) or 0.9% NaC1 (n = 5). Dexamethasone did not reduce the resulting infarct size. However, steroid treated animals had more brain tissue affected by haemorrhage, although this did not seem to affect survival.

Keywords

Middle Cerebral Artery Infarct Size Cerebral Infarct Middle Cerebral Artery Occlusion Infarct Volume 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Hartmann A, Menzel J, Buttinger C, Lange D (1979) Preservation of regional CBF in experimental ischaemic infarction by dexamethasone. Acta Neurol Scand [Suppl] 72: 306–307Google Scholar
  2. 2.
    Barbosa-Coutinho LM, Hartmann A, Hossmann K-A, Rommel T (1985) Effect of serum protein extravasation in experimental brain infarcts in monkeys. Acta Neuropathol (Berl) 65: 255–260CrossRefGoogle Scholar

Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • A. Hartmann
    • 1
  • G. Ebhardt
    • 2
  • Th. Rommel
    • 2
  • A. Meuer
    • 1
  1. 1.Neurologische UniversitätsklinikBonnFederal Republic of Germany
  2. 2.Städtisches Krankenhaus Köln-MerheimFederal Republic of Germany

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