Summary
Assessment of perinatal brain oedema is complicated by normal changes in brain water that accompany the marked physiological, biochemical and morphological alterations occurring during this phase of development. Multiexponential analysis of transverse decay curves (TDCs), derived from 128 echo CPMG images, of white matter (WM) made oedematous by either exposure of animals to triethyltin (TET) or cryogenic cortical lesions revealed a second, slower decay component not apparent in controls. More significantly, an obvious difference was noted between the TET and cryogenic lesion fast decay components which might serve as a basis to differentiate non-invasively cytotoxic and vasogenic oedemas.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Coulter DM, Avery ME (1980) Paradoxical reduction in tissue hydration with weight gain in neonatal rabbit pups. Pediatr Res 14: 1122–1126
Go GK, Edzes HT (1975) Water in brain oedema. Observations by the pulsed nuclear magnetic resonance technique. Arch Neurol 32: 462–465
Jolesz FA, Polack JF, Ruenzel PW et al (1984) Wallerian degeneration demonstrated by magnetic resonance: spectroscopic measurements on peripheral nerve. Radiology 152: 85–87
Lorenzo AV, Jolesz FA, Wallman JK et al (1989) Proton magnetic resonance studies of triethyltin-induced oedema during perinatal brain development in rabbits. J Neurosurg 70: 432–440
Mulkern RV, Bleier AR, Jakab P et al (1990) High field CPMG imaging sequences for transverse relaxation time studies. Magn Reson Med (in press)
Mulkern RV, Bleier AR, Adzamli IK et al (1989) Two-site exchange revisited: A new method for extracting exchange parameters in biological systems. Biophys J 55: 221–232
Norris JW, Pappius HM (1970) Cerebral water and electrolytes. Effect of asphyxia, hypoxia and hypercapnia. Arch Neurol 23: 248–258
Welch K (1980) The intracranial pressure in infants. J Neurosurg 52: 693–699
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 Springer-Verlag
About this paper
Cite this paper
Lorenzo, A.V., Mulkern, R.V., Wong, S.T.S., Colucci, V.M., Jolesz, F.A. (1990). MR Studies of Brain Oedema in the Developing Animal. In: Reulen, HJ., Baethmann, A., Fenstermacher, J., Marmarou, A., Spatz, M. (eds) Brain Edema VIII. Acta Neurochirurgica, vol 51. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9115-6_14
Download citation
DOI: https://doi.org/10.1007/978-3-7091-9115-6_14
Publisher Name: Springer, Vienna
Print ISBN: 978-3-7091-9117-0
Online ISBN: 978-3-7091-9115-6
eBook Packages: Springer Book Archive