Summary
The effect of reversible inhibitors of the monoamine oxidase type A (MAO-A), moclobemide (Aurorix®) and Ro 41-1049 (20 mg/kg i.p. each), as well as of reversible inhibitors of the MAO type B (MAO-B), Ro 19-6327 (1 mg/kg i.p.), on the outflow of dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) was studied in the rat by transstriatal microdialysis. Reversible MAO-A inhibitors markedly increased the output of DA and concomitantly decreased the output of DOPAC and HVA. These effects were absent with the highly selective MAO-B inhibitor Ro 19-6327.
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© 1990 Springer-Verlag
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Colzi, A., d’Agostini, F., Kettler, R., Borroni, E., Da Prada, M. (1990). Effect of selective and reversible MAO inhibitors on dopamine outflow in rat striatum: a microdialysis study. In: Riederer, P., Youdim, M.B.H. (eds) Amine Oxidases and Their Impact on Neurobiology. Journal of Neural Transmission, vol 32. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9113-2_9
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DOI: https://doi.org/10.1007/978-3-7091-9113-2_9
Publisher Name: Springer, Vienna
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