Summary
The influence of inhibition of uptake 2 and of O-methylation on β-adrenoceptor-mediated responses of guinea-pig trachea and rat uterus to some catecholamines was compared. The responses were more markedly enhanced by inhibition of O-methylation (by U-0521) than by inhibition of uptake2 (by hydrocortisone). The ranking order for the degree of supersensitivity caused by either U-0521 or hydrocortisone was different in the two tissues, suggesting differences between the O-methylating systems of those tissues. In experiments with 3H-isoprenaline metabolism, hydrocortisone had a weak inhibitory effect on O-methylation in both tissues.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Azevedo I, Osswald W (1976) Uptake, distribution and metabolism of isoprenaline in the dog saphenous vein. Naunyn-Schmiedebergs Arch Pharmacol 295:141–147.
Bryan LJ, Cole JJ, O’Donnell SR, Wanstall JC (1981) A study designed to explore the hypothesis that beta-1 adrenoceptors are “innervated” receptors and beta-2 adrenoceptors are “hormonal” receptors. J Pharmacol Exp Ther 216:395–400.
Constantine JW (1965) “Spirally cut tracheal strip preparation”. J Pharm Pharmacol 17:384.
Guimarães S (1982) Two adrenergic biophases in blood vessels. Trends Pharmacol Sci 3:159–161.
Guimarães S, Paiva MQ (1981a) Two distinct adrenoceptor-biophases in the vasculature: one for α-and the other for β-agonists. Naunyn-Schmiedebergs Arch Pharmacol 316:195–199.
Guimarães S, Paiva MQ (1981b) Two distinct biophases for adrenaline released by electrical stimulation or tyramine from the sympathetic nerve endings of the dog saphenous vein. Naunyn-Schmiedebergs Arch Pharmacol 316:200–204.
Guimarães S, Trendelenburg U (1985) Deviation supersensitivity and inhibition of saturables sites of loss. Trends Pharmacol Sci 6:371–374.
Guimarães S, Paiva MQ, Moura D, Proença J (1985) The saturability of a site of loss and the degree of supersensitivity to agonists which are substrates of this site of loss. Naunyn-Schmiedebergs Arch Pharmacol 329:30–35.
Head RJ, Irvine RJ, Barone S, Stitzel RE, De la Lande IS (1985) Non intracellular, cell-associated O-methylation of isoproterenol in the isolated rabbit thoracic aorta. J Pharmacol Exp Ther 324:184–189.
Paiva MQ, Guimarães S (1976) Influence of the blockade of extraneuronal uptake of the affinity of some amines for the β-adrenergic receptors of guinea-pig trachea and atria. Arch Pharmacol Toxicol 2:185–193.
Proença J, Paiva MQ, Guimarães S (1988) The guinea-pig trachea O-methylating system is more effective in modulating β2-than β1-adrenoceptor-mediated responses to isoprenaline. J Pharm Pharmacol 40:76–77.
Raxworthy MJ, Gulliver PA, Hughes PJ (1982) The cellular location of catechol-O-methyltransferase in rat liver. Naunyn-Schmiedebergs Arch Pharmacol 320:182–188.
Reid JJ, Stitzel RE, Head RJ (1986) Characterization of the O-methylation of catechol oestrogens by intact rabbit thoracic aorta and subcellular fractions thereof. Naunyn-Schmiedebergs Arch Pharmacol 334:17–28.
Roth SA (1980) Presence of membrane-bound catechol-O-methyltransferase in human brain. Biochem Pharmacol 29:3119–3122.
Trendelenburg U (1972) Factors influencing the concentration of catecholamines. In: Blaschko E, Muscholl E (eds) Catecholamines. Springer, Berlin Heidelberg New York (Handbook of experimental pharmacology, vol 33, pp 726–761).
Trendelenburg U (1988) The extraneuronal uptake and metabolism of catecholamines. In: Trendelenburg U, Weiner N (eds) Catecholamines I. Springer, Berlin Heidelberg New York (Handbook of experimental pharmacology vol 90, pp 279–319).
Uhlig W, Bönisch H, Trendelenburg U (1974) The O-methylation of extraneuronally stored isoprenaline in the perfused rat. Naunyn-Schmiedebergs Arch Pharmacol 283:245–261.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 Springer-Verlag
About this paper
Cite this paper
Proença, J., Paiva, M.Q., Guimarães, S. (1990). Supersensitivity to catecholamines after inhibition of extraneuronal uptake (uptake2) or O-methylation. In: Riederer, P., Youdim, M.B.H. (eds) Amine Oxidases and Their Impact on Neurobiology. Journal of Neural Transmission, vol 32. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9113-2_63
Download citation
DOI: https://doi.org/10.1007/978-3-7091-9113-2_63
Publisher Name: Springer, Vienna
Print ISBN: 978-3-211-82239-5
Online ISBN: 978-3-7091-9113-2
eBook Packages: Springer Book Archive