Supersensitivity to catecholamines after inhibition of extraneuronal uptake (uptake2) or O-methylation

  • J. Proença
  • M. Q. Paiva
  • S. Guimarães
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 32)


The influence of inhibition of uptake 2 and of O-methylation on β-adrenoceptor-mediated responses of guinea-pig trachea and rat uterus to some catecholamines was compared. The responses were more markedly enhanced by inhibition of O-methylation (by U-0521) than by inhibition of uptake2 (by hydrocortisone). The ranking order for the degree of supersensitivity caused by either U-0521 or hydrocortisone was different in the two tissues, suggesting differences between the O-methylating systems of those tissues. In experiments with 3H-isoprenaline metabolism, hydrocortisone had a weak inhibitory effect on O-methylation in both tissues.


Ranking Order Sympathomimetic Amine Sympathetic Nerve Ending Weak Inhibitory Effect Catechol Oestrogen 
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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • J. Proença
    • 1
  • M. Q. Paiva
    • 2
  • S. Guimarães
    • 2
  1. 1.Department of Pharmacology, Faculties of PharmacyUniversity of PortoPortugal
  2. 2.Department of Pharmacology, Faculties of MedicineUniversity of PortoPortoPortugal

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