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Amine Oxidases and Their Impact on Neurobiology pp 323–326Cite as

Amine oxidase activities in chemically-induced mammary cancer in the rat

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Part of the book series: Journal of Neural Transmission ((NEURAL SUPPL,volume 32))

Summary

The activities and distributions of monoamine oxidase (MAO) and semicarbazide-sensitive amine oxidase (SSAO) were studied in solid breast tumours induced in rat by treatment with 7,12-dimethylbenz(α)anthracene (DMBA).

It was observed that increasing degree of malignancy was associated with an increase of MAO-A activity an decrease of MAO-B and SSAO activities. The Km values did not change significantly with malignancy but Vmax values for MAO-A increased whereas Vmax for MAO-B and SSAO diminished with malignancy.

It was detected in the more malignant tumours the presence of endogenous reversible inhibitor of SSAO activity not removed by dialysis.

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References

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Author information

Authors and Affiliations

  1. Departament Bioquímica i Biologia Molecular, Universität Autónoma de Barcelona, 08193, Bellaterra (Barcelona), Spain

    J. M. Lizcano, K. F. Tipton & Dr. M. Unzeta

  2. Departament Biologia Cellular i Fisiologia, Facultat de Medicina, Universitat Autónoma de Barcelona, Barcelona, Spain

    E. Escrich

Authors
  1. J. M. Lizcano
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  2. E. Escrich
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  3. K. F. Tipton
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  4. Dr. M. Unzeta
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Editor information

Editors and Affiliations

  1. Department of Psychiatry, University of Wurzburg, Federal Republic of Germany

    Peter Riederer

  2. Israel Institute of Technology, Technion, Haifa, Israel

    Moussa B. H. Youdim

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© 1990 Springer-Verlag

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Lizcano, J.M., Escrich, E., Tipton, K.F., Unzeta, M. (1990). Amine oxidase activities in chemically-induced mammary cancer in the rat. In: Riederer, P., Youdim, M.B.H. (eds) Amine Oxidases and Their Impact on Neurobiology. Journal of Neural Transmission, vol 32. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9113-2_42

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  • DOI: https://doi.org/10.1007/978-3-7091-9113-2_42

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-82239-5

  • Online ISBN: 978-3-7091-9113-2

  • eBook Packages: Springer Book Archive

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