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Senile dementia of Alzheimer’s type and Parkinson’s disease: neurochemical overlaps and specific differences

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Book cover Early Markers in Parkinson’s and Alzheimer’s Diseases

Part of the book series: New Vistas in Drug Research ((DRUG RESEARCH,volume 1))

Summary

Parkinson’s disease (PD) is characterized by a clear rank order with respect to neuropathological findings. Both substantia nigra (SN) and locus coeruleus (LC) are severely damaged, whilst nucleus raphe dorsalis (NRD) and nucleus basalis of Meynert (NbM) are only moderately affected. In senile dementia of Alzheimer’s type (SDAT) the rank order is less clearly defined, SN being slightly and LC, NRD, and NbM being moderately damaged. The loss of neurotransmitter concentrations found in PD and SDAT by neurochemical analysis only partly corresponds to the neuronal loss found in SN, LC, NDR, and NbM. This may indicate the ability of the neurotransmitter systems to compensate neuronal loss. Possible pathomechanisms underlying PD and SDAT are discussed.

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Author information

Authors and Affiliations

  1. Clinical Neurochemistry, Department of Psychiatry, University of Würzburg, Federal Republic of Germany

    P. Riederer, E. Sofic, G. Moll, A. Freyberger & W. Gsell

  2. Ludwig-Boltzmann-Institute of Clinical Neurobiology, Lainz Hospital, Vienna, Austria

    I. Wichart & K. Jellinger

  3. Department of Psychiatry, Landeskrankenhaus Mauer/ Amstetten, Austria

    G. Hebenstreit

  4. Department of Pharmacology, Technion, Haifa, Israel

    M. B. H. Youdim

Authors
  1. P. Riederer
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  2. E. Sofic
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  3. G. Moll
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  4. A. Freyberger
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  5. I. Wichart
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  6. W. Gsell
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  7. K. Jellinger
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  8. G. Hebenstreit
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  9. M. B. H. Youdim
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Editor information

Editors and Affiliations

  1. Farmitalia Carlo Erba, R & D, Via Imbonati 24, I-20159, Milan, Italy

    Philippe Dostert , Margherita Strolin Benedetti  & Romeo Roncucci ,  & 

  2. Clinical Neurochemistry, Department of Psychiatry, University of Würzburg, Füchsleinstrasse 15, D-W-8700, Würzburg, Federal Republic of Germany

    Peter Riederer

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© 1990 Springer-Verlag/Wien

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Riederer, P. et al. (1990). Senile dementia of Alzheimer’s type and Parkinson’s disease: neurochemical overlaps and specific differences. In: Dostert, P., Riederer, P., Strolin Benedetti, M., Roncucci, R. (eds) Early Markers in Parkinson’s and Alzheimer’s Diseases. New Vistas in Drug Research, vol 1. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9098-2_21

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  • DOI: https://doi.org/10.1007/978-3-7091-9098-2_21

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-9100-2

  • Online ISBN: 978-3-7091-9098-2

  • eBook Packages: Springer Book Archive

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