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Neurotransmitter Actions and Interactions pp 259–268Cite as

The effects of aging on MAO activity and amino acid levels in rat brain

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Part of the book series: Journal of Neural Transmission ((NEURAL SUPPL,volume 29))

Summary

The possibility that age-related changes in amino acid levels in various rat brain areas might correlate with modifications of monoamine oxidase (MAO) activity, already found with aging, has been examined.

Taurine, aspartic acid and glutamic acid levels were found to be unchanged or decreased with age, whereas GABA and glutamine concentrations increased or remained unchanged. Serine and glycine (except in pons-medulla) levels were found to be unaffected by age. The increase in total MAO activity with aging in some brain areas might contribute to the changes in amino acid levels. Likewise, the possible influence of age-induced changes in activity of various enzymes involved in H2O2 and NH3 detoxication and in amino acid biosynthesis on rat brain amino acid levels are considered. Oral administration of clorgyline or 1-deprenyl to young rats did not significantly modify the concentrations of most brain amino acids.

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Author information

Authors and Affiliations

  1. Farmitalia Carlo Erba, R&D—Erbamont Group, Milan, Italy

    M. Strolin Benedetti, M. Cini, R. Fusi, P. Marrari & Dr. P. Dostert

  2. Farmitalia Carlo Erba, Research and Development, Via Imbonati 24, I-20159, Milan, Italy

    Dr. P. Dostert

Authors
  1. M. Strolin Benedetti
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  2. M. Cini
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  3. R. Fusi
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  4. P. Marrari
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  5. Dr. P. Dostert
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Editor information

Editors and Affiliations

  1. Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel

    Moussa B. H. Youdim

  2. Biochemistry Department, Trinity College, Dublin, Ireland

    Keith F. Tipton

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© 1990 Springer-Verlag

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Benedetti, M.S., Cini, M., Fusi, R., Marrari, P., Dostert, P. (1990). The effects of aging on MAO activity and amino acid levels in rat brain. In: Youdim, M.B.H., Tipton, K.F. (eds) Neurotransmitter Actions and Interactions. Journal of Neural Transmission, vol 29. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9050-0_25

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  • DOI: https://doi.org/10.1007/978-3-7091-9050-0_25

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-82142-8

  • Online ISBN: 978-3-7091-9050-0

  • eBook Packages: Springer Book Archive

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