Summary
Biodegradable controlled-release microcapsule systems made with the biocompatible biodegradable polyester excipient poly [DL-lactide-co-gly-colide] constitute an exciting new technology for drug delivery to the central nervous system (CNS). The present study describes functional observations indicating that implantation of dopamine (DA) microcapsules encapsulated within two different polymer excipients into denervated striatal tissue assures a prolonged release of the transmitter in vivo. This technology has a considerable potential for basic and possibly clinical research.
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© 1990 Springer-Verlag
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McRae, A., Hjorth, S., Mason, D., Dillon, L., Tice, T. (1990). Implantable microencapsulated dopamine (DA): prolonged functional release of DA in denervated striatal tissue. In: Youdim, M.B.H., Tipton, K.F. (eds) Neurotransmitter Actions and Interactions. Journal of Neural Transmission, vol 29. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9050-0_20
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DOI: https://doi.org/10.1007/978-3-7091-9050-0_20
Publisher Name: Springer, Vienna
Print ISBN: 978-3-211-82142-8
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