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Nimodipine in the Prevention of Ischaemic Deficits After Aneurysmal Subarachnoid Haemorrhage

An Analysis of Recent Clinical Studies

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Prevention and Treatment of Delayed Ischaemic Dysfunction in Patients with Subarachnoid Haemorrhage

Part of the book series: Acta Neurochirurgica Supplementum ((NEUROCHIRURGICA,volume 45))

Summary

An analysis of the recent trials on the effect of nimodipine on the prevention of delayed ischaemic deficits (DID) due to vasospasm provides strong evidence that the drug reduces the incidence and the severity of DID. Placebo-controlled prospective randomized studies with oral administration of nimodipine prove that patients treated with nimodipine suffer severe disabihty or death due to vasospasm less frequently than those not treated. Non-controlled open prospective trials with early surgery and intravenous and oral nimodipine present the lowest pubhshed incidence of DID in aneurysmal subarachnoid haemorrhage.

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Author information

Authors and Affiliations

  1. Neurochirurgische Universitätsklinik, Hugstetter Strasse 55, D-7800, Freiburg i. Br., Federal Republic of Germany

    Prof. Joachim M. Gilsbach

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  1. Prof. Joachim M. Gilsbach
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Editors and Affiliations

  1. Department of Neurosurgery, University Hospital, Inselspital, Bern, Switzerland

    Hans-Jürgen Reulen

  2. Department of Neurosurgery, C.H.U. Pitié-Salpêtrière, Paris, France

    Jacques Philippon

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© 1988 Springer-Verlag

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Gilsbach, J.M. (1988). Nimodipine in the Prevention of Ischaemic Deficits After Aneurysmal Subarachnoid Haemorrhage. In: Reulen, HJ., Philippon, J. (eds) Prevention and Treatment of Delayed Ischaemic Dysfunction in Patients with Subarachnoid Haemorrhage. Acta Neurochirurgica Supplementum, vol 45. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9014-2_7

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  • DOI: https://doi.org/10.1007/978-3-7091-9014-2_7

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-82096-4

  • Online ISBN: 978-3-7091-9014-2

  • eBook Packages: Springer Book Archive

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