Summary
Depression is more prominent in untreated patients in the early phase of the disease than in treated patients who have suffered from Parkinson’s disease more than six years. In depressive Parkinson patients low levels of urinary 3-methoxy-4-hydroxyphenylglycol (MHPG) and an abnormal Dexamethasone Suppression Test were found. Although a reactive component could not be excluded, both pharmacological and biochemical data support the hypothesis that alterations in norepinephrine metabolism could be the cause for depression in Parkinson’s disease.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Andersen J, Aabro E, Gulmann N, Hjelmsted A, Pedersen HE (1980) Antidepressive treatment in Parkinson’s disease. Acta Neurol Scand 62: 210–219
Cagnasso M, Biondi PA (1974) Gaschromatographic estimation of urinary vanilmandelicacid and 3-methoxy-4-hydroxyphenylethyleneglycol after their purification on Sephadex LH 20. Ital J Biochem 5: 345–355
Celesia GG, Wanamaker WM (1972) Psychiatric disturbances in Parkinson’s disease. Dis New System 33: 577–583
Demel I, Schubert H, Unterthiner D (1980) Initialsymptome bei depressiven Erkrankungen. Neurol Psychiat 6: 263–266
Gotham AM, Brown RG, Marsden CD (1986) Depression in Parkinson’s disease: a quantitative and qualitative analysis. Neurol Neurosurg Psychiatr 49: 381–389
Kawamura T, Kinoshita M, Iwasaki Y, Nemoto H (1987) Low-dose dexamethasone suppression test in Japanese patients with Parkinson’s disease. J Neurol 234: 264–265
Kopin IJ, Jimerson DC, Markey SP, Ebert MH, Polinski RJ (1984) Disposition and metabolism of MHPG in humans: Application to studies in depression. Pharmacopsychiatry 17: 3–8
Mayeux R, Stern Y, Cote L, Williams JBW (1984) Altered serotonin metabolism in depressed patients with Parkinson’s disease. Neurology 34: 642–646
Mindham RHS, Marsden CD, Parkes JD (1976) Psychiatric symptoms during L-Dopa therapy for Parkinson’s disease and their relationship to physical disability. Psychol Med 6: 23–33
Riederer P, Birkmayer W (1980) A new concept: brain area specific imbalance of neurotransmitters in depression syndrome—human brain studies. In: Usdin E, Sourkes TL, Youdim MBH (eds) Enzymes and neurotransmitters in mental disease. Wiley, New York, p 261
Robins AH (1976) Depression in patients with parkinsonism. Br J Psychiatr 128: 141–145
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Springer-Verlag/Wien
About this paper
Cite this paper
Kuhn, W., Fuchs, G., Laux, G., Rupprecht, R., Przuntek, H. (1989). Clinical and biochemical characteristics of early depression in Parkinson’s disease. In: Przuntek, H., Riederer, P. (eds) Early Diagnosis and Preventive Therapy in Parkinson’s Disease. Key Topics in Brain Research. Springer, Vienna. https://doi.org/10.1007/978-3-7091-8994-8_6
Download citation
DOI: https://doi.org/10.1007/978-3-7091-8994-8_6
Publisher Name: Springer, Vienna
Print ISBN: 978-3-211-82080-3
Online ISBN: 978-3-7091-8994-8
eBook Packages: Springer Book Archive