Summary
Seventy-four of 78 patients with Parkinson’s disease (PD) had Lewy bodies in the substantia nigra. Two without Lewy bodies had striatonigral degeneration and two had post-encephalitic pathology. Lewy bodies in controls occurred in 3.6% to 11.1% between the sixth and tenth decades, and similar figures were obtained in other common parkinsonian disorders and Alzheimer’s disease. Lewy bodies can also occur in corticobasal degeneration and Hallervorden-Spatz disease. The pathological diagnosis of PD depends on finding Lewy bodies in the substantia nigra, but other parkinsonian disorders must be excluded.
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Gibb, W.R.G. (1989). The diagnostic relevance of Lewy bodies and other inclusions in Parkinson’s disease. In: Przuntek, H., Riederer, P. (eds) Early Diagnosis and Preventive Therapy in Parkinson’s Disease. Key Topics in Brain Research. Springer, Vienna. https://doi.org/10.1007/978-3-7091-8994-8_20
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DOI: https://doi.org/10.1007/978-3-7091-8994-8_20
Publisher Name: Springer, Vienna
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