Technique of lumbar chemonucleolysis

  • J.-D. Laredo
  • J. Busson
  • M. Wybier
  • M. Bard


Intrathecal injection of chymopapain causes fatal hemorrhage in rabbits and dogs [12]. To prevent the possibility of chymopapain leaking into the subarachnoid space, chemonucleolysis should not be performed immediately after myelography in order to allow any dural leak to seal [12]. McCulloch recommends a minimum delay of 24 hours [12]. We agree with other practitioners and require at least seven days between myelography and enzyme injection [1].


Iliac Crest Nucleus Pulposus Disc Herniation Facet Joint Disc Space 
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Copyright information

© Springer-Verlag/Wien 1988

Authors and Affiliations

  • J.-D. Laredo
    • 1
  • J. Busson
    • 1
  • M. Wybier
    • 2
  • M. Bard
    • 1
  1. 1.Department of Bone and Joint RadiologyHôpital LariboisièreParisFrance
  2. 2.Department of Bone and Joint RadiologyHôpital CochinParisFrance

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