Eosinophilic granuloma of bone: direct steroid injection

  • S. Wallace
  • C. H. Carrasco
  • C. Charnsangavej
  • M. Cohen


Eosinophilic granuloma of bone is a benign condition that was described as a distinct clinical and pathological entity by Lichtenstein and Jaffe [1] and Otani and Ehrlich [2] in 1940. One year later, Farber suggested a pathological gradation including eosinophilic granuloma, Hand-Schuller-Christian disease, and Letterer-Siwe disease [3]. In 1953, Lichtenstein consolidated these three entities under the term “histiocytosis X”, thereby emphasizing the inflammatory proliferative reaction common to all three forms of the disease as well as their indefinite etiologies [4]. Eosinophilic granuloma is generally accepted to represent the benign localized form of the disease, while Hand-Schuller-Christian and Letterer-Siwe diseases are thought to be disseminated types; however, the validity of this unifying concept is controversial and other authors stress their individual nature inspite of certain histological similarities [5, 6, 7].


Bone Cyst Eosinophilic Granuloma Percutaneous Needle Biopsy Intralesional Injection Line Membrane 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Lichtenstein L, Jaffe HL (1940) Eosinophilic granuloma of bone. With report of a case. Am J Pathol 16: 595–604PubMedGoogle Scholar
  2. 2.
    Otani S, Ehrlich JC (1940) Solitary granuloma of bone. Simulating primary neoplasm. Am J Pathol 16: 479–490PubMedGoogle Scholar
  3. 3.
    Farber S (1941) The nature of “solitary or eosinophilic granuloma” of bone (abst). Am J Pathol 17: 625–626Google Scholar
  4. 4.
    Lichtenstein L (1953) Histiocytosis X. Integration of eosinophilic granuloma of bone. “Letter-Siwe disease”, and “Schuller-Christian disease” as related manifestations of a single nosologic entity. Arch Pathol 56: 84–102Google Scholar
  5. 5.
    McGavran MH, Spady HA (1960) Eosinophilic granuloma of bone. A study of twenty-eight cases. J Bone Joint Surg [Am] 42: 979–992Google Scholar
  6. 6.
    Otani S (1957) A discussion on eosinophilic granuloma of bone, Letter-Siwe disease and Schuller-Christian disease. J Mt Sinai Hosp NY 24: 1079–1092Google Scholar
  7. 7.
    Siwe S (1949) The reticulo-endothelioses in children. Adv Pediatr 4: 117–143Google Scholar
  8. 8.
    Den Herder BA (1973) Changing views on eosinophilic granuloma of bone. Radiol Clin Biol 42: 218–221Google Scholar
  9. 9.
    Thompson J, Buechner HA, Fishman R (1958) Eosinophilic granuloma of the lung. Ann Intern Med 48: 1134–1145PubMedGoogle Scholar
  10. 10.
    Carrie C (1958) Zur Behandlung des eosinophilen Granuloms. Hautarzt 9: 38–40PubMedGoogle Scholar
  11. 11.
    Starling KA (1977) Histiocytosis. In: Sutow WW, Vietti TJ, Fernbach DJ (eds) Clinical pediatric oncology, 2nd edn. Mosby, St. Louis, pp 467–486Google Scholar
  12. 12.
    Cohen M, Zornoza J, Cangir A, Murray JA, Wallace S (1980) Direct injection of methylprednisolone sodium succinate in the treatment of solitary eosinophilic granuloma of bone. A report of 9 cases. Radiology 136: 289–293PubMedGoogle Scholar
  13. 13.
    Scaglietti O, Marchetti PG, Barolozzi P (1979) The effects of methylprednisolone acetate in the treatment of bone cysts. Results of three years follow-up. J Bone Joint Surg [Br] 61: 200–204Google Scholar
  14. 14.
    Campanacci M, de Sessa L, Bellando Randone P (1975) Cisti ossea. (Revisione de 275 osservazioni. Risultati della cura chirurgica e primi risultati della cura incruenta con metilprednisolone acetato ). Chir Organi Mov 62: 471–482PubMedGoogle Scholar
  15. 15.
    Gualtieri I, Gualtieri G, Montefusco E (1976) Ristultati ottenuti nel trattamento delle cisti ossee mediante infiltrazione con acetato di metilprednisolone. Osp Ital Chir 29: 155–160Google Scholar
  16. 16.
    Campanacci M, de Sessa L, Trentani C (1977) Cura incruenta della cisti ossea con iniezioni locali di metilprednisolone acetata secondo Scaglietti. Ital J Orthop Traumatol 3: 27–36PubMedGoogle Scholar
  17. 17.
    Savastano AA (1979) The treatment of bone cysts with intracyst injection of steroids. Injection of steroids will largely replace surgery in the treatment of benign bone cysts. Rhode Island Med J 62: 93–95Google Scholar
  18. 18.
    Nauert T, Zornoza J, Ayala A, Harle TS (1983) Eosinophilic granuloma of bone: diagnosis and management. Skeletal Radiol 10: 227–235PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag/Wien 1988

Authors and Affiliations

  • S. Wallace
    • 1
  • C. H. Carrasco
    • 1
  • C. Charnsangavej
    • 1
  • M. Cohen
    • 1
  1. 1.Department of Diagnostic RadiologyThe University of Texas System Cancer Center M. D. Anderson Hospital and Tumor InstituteHoustonUSA

Personalised recommendations