Summary
To understand molecular mechanisms of clonal expansion of lymphocytes we have isolated cDNA clones for two lymphokines, interleukins (IL) 4 and 5 that induce proliferation and maturation of B-lymphocytes. Structures of IL-4 and IL-5 revealed a remote homology with other lymphokines such as IL-3 and γ-interferon. IL-4 and IL-5 were shown to affect not only B-lymphocates but also T-lymphocytes and several other cells derived from bone marrow stem cells. We have also studied the structure and function of the IL-2 receptor: our focus was the molecular basis for the high and low affinity states of the receptor encoded by the identical cDNA. We propose the affinity conversion model that the high-affinity state of the IL-2 receptor is a ternary complex of IL-2, the IL-2 receptor, and a postulated “converter protein”, which is fewer in number than the receptors.
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© 1987 Springer-Verlag/Wien
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Kinashi, T. et al. (1987). Growth Factors and Receptors of Lymphocytes. In: Sano, K., Ishii, S. (eds) Plasticity of the Central Nervous System. Acta Neurochirurgica Supplementum, vol 41. Springer, Vienna. https://doi.org/10.1007/978-3-7091-8945-0_16
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DOI: https://doi.org/10.1007/978-3-7091-8945-0_16
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